poly(ADP-ribose) polymerase
The Inhibition and Treatment of Breast Cancer with Poly (ADP-ribose) Polymerase (PARP-1) Inhibitors
... BRCA1 and BRCA2 mutations are responsible for most familial breast carcinomas. Recent reports carried out in non-cancerous mouse BRCA1- or BRCA2-deficient embryonic stem (ES) cells, and hamster BRCA2-deficient cells have ...
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Herpes Simplex Virus 1 Infection Activates Poly(ADP-Ribose) Polymerase and Triggers the Degradation of Poly(ADP-Ribose) Glycohydrolase
... the poly(ADP-ribose) polymerase (PARP) family of enzymes are major consumers of NAD ⴙ , which they utilize to form poly(ADP-ribose) (PAR) chains on protein substrates in ...
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9 Phenyl Acridine: A Possible Poly (ADP ribose) Polymerase 1 Inhibitor
... Acridines are well known for their role in a wide range of biological functions. They have been used for treatment of different diseases arising from viral, bacterial and protozoal infections [1-3] and are also known to ...
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Poly(ADP-Ribose) Polymerase Is a Substrate Recognized by Two Metacaspases of Podospora anserina
... recombinant poly(ADP-ribose) polymerase (PARP), a known substrate of mammalian caspases, led to the identification of PARP as a substrate of the two ...
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Poly(ADP-Ribose) Polymerase 1 Promotes Transcriptional Repression of Integrated Retroviruses
... Poly(ADP-ribose) polymerase 1 (PARP-1) is a key cellular en- zyme in DNA repair and chromatin-remodeling processes (13, ...of ADP ribose molecules from NAD ⫹ to acceptor proteins ...
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Asthma and poly(ADP-ribose) polymerase inhibition: a new therapeutic approach
... many poly(ADP-ribose) polymerase (PARP) inhibitors have been enrolled in clinical trials as a combination therapy for several types of cancer, and many of these were licensed by the Food and ...
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Update on Poly ADP ribose polymerase inhibition for ovarian cancer treatment
... Background: Despite standard treatment for epithelial ovarian cancer (EOC), that involves cytoreductive surgery followed by platinum-based chemotherapy, and initial high response rates to these, up to 80 % of patients ...
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Regulation of Epstein-Barr Virus OriP Replication by Poly(ADP-Ribose) Polymerase 1
... Poly(ADP-ribose) polymerase (PARP) is an abundant, chromatin-associated, NAD-dependent enzyme that functions in multiple chromosomal processes, including DNA replication and chromatin ...by ...
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Review Article Potential biomarkers of Poly (ADP-ribose) polymerase inhibitors for cancer therapy
... on Poly (ADP-ribose) polymerase (PARP) inhibitors have been emerging as a novel therapy for treatment of patients with advanced ovarian ...
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Treatment of breast cancer 2 (BRCA2) mutant follicular dendritic cell sarcoma with a poly ADP ribose polymerase (PARP) inhibitor: a case report
... Due to the finding of a BRCA2 mutation, it was decided to treat with the combination of carboplatin and a poly ADP-ribose polymerase (PARP) inhibitor. A compas- sionate supply of veliparib was ...
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Poly(ADP-ribose)polymerase-1 modulates microglial responses to amyloid β
... Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear protein that regulates cellular inflammatory responses through interactions with several transcription factors ...Auto poly ...
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Noncleavable poly(ADP ribose) polymerase 1 regulates the inflammation response in mice
... Poly(ADP-ribosyl)ation is rapidly formed in cells following DNA damage and is regulated by poly(ADP-ribose) polymerase-1 (PARP-1). PARP-1 is known to be involved in various ...
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Activation of the Poly(ADP-Ribose) Polymerase Pathway in Human Heart Failure
... Poly(ADP-ribose) polymerase (PARP) activation has been implicated in the pathogenesis of acute and chronic myocardial dys- function and heart ...of poly-ADP ribosylated ...
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Combination of erlotinib and a PARP inhibitor inhibits growth of A2780 tumor xenografts due to increased autophagy
... and poly(ADP-ribose) polymerase (PARP) inhibitors have known activity in advanced ovarian cancer, the effect of combined therapy against EGFR and PARP in this population has not been ...
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Poly (ADP-ribose) polymerase 3 (PARP3), a potential repressor of telomerase activity
... the major missions for the coming years in the PARP field is to further dissect the biological activities of the emerging DNA-dependent PARPs (i.e. PARP3, Tankyr- ase), and to exploit their known structural features for ...
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Current status of poly(ADP-ribose) polymerase inhibitors and future directions
... of poly(ADP-ribose) polymerases (PARPs), which play a key role in DNA damage/repair pathways, have been developed as antitumor agents based on the concept of synthetic ...
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Olaparib in the management of ovarian cancer
... a poly(ADP-ribose) polymerase (PARP) inhibitor, capitalizes on this concept and is the first drug in its class approved for patients with ovarian ...
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<div>Emerging treatment options for ovarian cancer: focus on rucaparib</div>
... Abstract: Poly(ADP-ribose) polymerase (PARP) inhibitors (PARPi) are an exciting class of anticancer drugs, which have revolutionized the management of BRCA mutant/homologous ...
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QSAR, Docking and Invitro Antioxidant Activity Study of Novel Chromone Derivatives
... (ADP-ribose) polymerase-1 (PARP-1) is a member of the PARP enzyme family consisting of PARP-1 and sev- eral recently identified novel poly (ADP-ribosylating) en- ...and ...
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CYTOTOXICITY AND IN SILICO STUDIES OF ANETHOLE IN TRIPLE NEGATIVE BREAST CANCER CELLS
... compound collections are needed to carry out such in-silico experiments. The compound, anethole, was subjected to in silico studies for its efficacy against the target proteins present on the triple negative cancer ...
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