Poly(ADP-ribosyl)polymerase
Poly(ADP-ribose)polymerase-1 modulates microglial responses to amyloid β
... Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear protein that regulates cellular inflammatory responses through interactions with several transcription factors ...Auto poly ...
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Herpes Simplex Virus 1 Infection Activates Poly(ADP-Ribose) Polymerase and Triggers the Degradation of Poly(ADP-Ribose) Glycohydrolase
... the poly(ADP-ribose) polymerase (PARP) family of enzymes are major consumers of NAD ⴙ , which they utilize to form poly(ADP-ribose) (PAR) chains on protein substrates in response to DNA ...
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Noncleavable poly(ADP ribose) polymerase 1 regulates the inflammation response in mice
... Poly(ADP-ribosyl)ation is rapidly formed in cells following DNA damage and is regulated by poly(ADP-ribose) polymerase-1 (PARP-1). PARP-1 is known to be involved in various ...
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Asthma and poly(ADP-ribose) polymerase inhibition: a new therapeutic approach
... many poly(ADP-ribose) polymerase (PARP) inhibitors have been enrolled in clinical trials as a combination therapy for several types of cancer, and many of these were licensed by the Food and Drug ...
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Poly(ADP-Ribose) Polymerase Is a Substrate Recognized by Two Metacaspases of Podospora anserina
... recombinant poly(ADP-ribose) polymerase (PARP), a known substrate of mammalian caspases, led to the identification of PARP as a substrate of the two ...
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Update on Poly ADP ribose polymerase inhibition for ovarian cancer treatment
... Background: Despite standard treatment for epithelial ovarian cancer (EOC), that involves cytoreductive surgery followed by platinum-based chemotherapy, and initial high response rates to these, up to 80 % of patients ...
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Original Article Polymorphisms in poly (ADP-ribose) polymerase-1 (PARP1) promoter and 3’ untranslated region and their association with PARP1 expression in breast cancer patients
... Original Article Polymorphisms in poly ADP-ribose polymerase-1 PARP1 promoter and 3’ untranslated region and their association with PARP1 expression in breast cancer patients Lili Zhai1*[r] ...
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Poly(ADP-Ribose) Polymerase 1 Promotes Transcriptional Repression of Integrated Retroviruses
... Poly(ADP-ribose) polymerase 1 (PARP-1) is a key cellular en- zyme in DNA repair and chromatin-remodeling processes (13, ...of ADP ribose molecules from NAD ⫹ to acceptor proteins or to a ...
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Activation of the Poly(ADP-Ribose) Polymerase Pathway in Human Heart Failure
... Poly(ADP-ribose) polymerase (PARP) activation has been implicated in the pathogenesis of acute and chronic myocardial dys- function and heart ...of poly-ADP ribosylated ...
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Potential biological role of poly (ADP-ribose) polymerase (PARP) in male gametes
... of Poly (ADP-ribose) polymerase (PARP), a DNA repair enzyme, and its homologues has recently been shown in male germ cells, specifically during stage VII of ...
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9 Phenyl Acridine: A Possible Poly (ADP ribose) Polymerase 1 Inhibitor
... Acridines are well known for their role in a wide range of biological functions. They have been used for treatment of different diseases arising from viral, bacterial and protozoal infections [1-3] and are also known to ...
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Poly (ADP-ribose) polymerase 3 (PARP3), a potential repressor of telomerase activity
... the major missions for the coming years in the PARP field is to further dissect the biological activities of the emerging DNA-dependent PARPs (i.e. PARP3, Tankyr- ase), and to exploit their known structural features for ...
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Current status of poly(ADP-ribose) polymerase inhibitors and future directions
... of poly(ADP-ribose) polymerases (PARPs), which play a key role in DNA damage/repair pathways, have been developed as antitumor agents based on the concept of synthetic ...
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Poly(ADP-Ribosyl)ation of High Mobility Group Box 1 (HMGB1) Protein Enhances Inhibition of Efferocytosis
... highly poly(ADP-ribosyl)ated (PARylated). Gene deletion of poly(ADP)-ribose polymerase (PARP)-1 or pharmacological inhi- bition of PARP-1 decreased the release of HMGB1 from the ...
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Flow-cytometric assessment of cellular poly(ADP-ribosyl)ation capacity in peripheral blood lymphocytes
... is poly(ADP-ribose) polymerase-1 (PARP-1, EC ...of poly(ADP-ribose) ...of poly(ADP-ribose) metabolism in the ageing process has long been suggested, as we could show that ...
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Regulation of Wnt/ß-catenin signalling by tankyrase-dependent poly(ADP-ribosyl)ation and scaffolding
... sumoylation, poly(ADP-ribosyl)ation (PARylation) and ...The poly(ADP- ribose)polymerase (PARP) tankyrase PARylates AXIN1/2, an essential central scaffolding protein in the ...
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Defective DNA repair mechanisms in prostate cancer: impact of olaparib
... aggressiveness. Poly adenosine diphosphate ribose polymerase (PARP) proteins play a key role in DNA repair mechanisms and represent a valid target for new ...
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Polyoma virus minichromosomes: poly ADP-ribosylation of associated chromatin proteins.
... Specific activities of polyADP-rib polymerase of HeLa cell nucleosomes and polyoma RI and mature chromatin Incorporation into histone fractionb Poly ADP-ribosylationa Source of chromatin[r] ...
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Combination of erlotinib and a PARP inhibitor inhibits growth of A2780 tumor xenografts due to increased autophagy
... and poly(ADP-ribose) polymerase (PARP) inhibitors have known activity in advanced ovarian cancer, the effect of combined therapy against EGFR and PARP in this population has not been ...
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PubMedCentral-PMC5438853.pdf
... Differentiation-Associated Downregulation of Poly(ADP-Ribose) Polymerase-1 Expression in Myoblasts Serves to Increase Their Resistance to Oxidative Stress. Nam YJ, Mani K, Ashton AW, Pe[r] ...
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