Polycomb proteins and stem cell renewal
Polycomb proteins and breast cancer
... outcomes. Polycomb proteins are emerging as important factors involved in breast cancer ...formation. Polycomb proteins play a crucial role in embryogenesis, early development, stem ...
285
The role of polycomb group proteins in hematopoietic stem cell (HSC) self-renewal and leukemogenesis
... PcG proteins and how regulation of these genes affects the fate of normal hematopoietic and ...normal stem cells, and ultimately how complex composition might relate to specific target gene ...PcG ...
Contribution of Polycomb group proteins to olfactory basal stem cell self renewal in a novel c KIT+ culture model and in vivo
... Methods. Cell culture and reagents Olfactory tissue was obtained from adult wild-type mice or from c-Kit CreERT2+/− ...m cell strainer, pelleted and resuspended in sort ...
11
Ring1a/b polycomb proteins regulate the mesenchymal stem cell niche in continuously growing incisors
... the renewal of tooth-forming tissues at the apex of incisors deeply embedded in the ...of cell proliferation in 17 day-old Ring1a / ;Ring1b cko/cko incisor ...
14
Polycomb Group Proteins: Multi-Faceted Regulators of Somatic Stem Cells and Cancer
... aging, stem cell defects, and cancer ( Ito et ...PcG proteins play a role in DNA damage repair ( Figure 3 ...RAD50 proteins strongly suggests that this PRC2 protein promotes the nonhomologous ...
15
Polycomb-like 2 Associates with PRC2 and Regulates Transcriptional Networks during Mouse Embryonic Stem Cell Self-Renewal and Differentiation
... However, experience reveals that even when grown under self-renewal culture conditions, a small but noticeable per- centage of ESCs commit and undergo morphologically distinguishable differentiation. Furthermore, ...
14
DNA methylation in stem cell renewal and multipotency
... multiple cell types, multipotent stem cells extracted from many adult tissues are an attractive stem cell resource for the replacement of damaged tissues in regenerative ...adult stem ...
9
Regulation of Hematopoietic Stem Cell Self-Renewal
... hematopoietic stem cell (HSC). Because most mature blood stem cells have a limited life span, the ability of HSCs to perpetuate themselves through self-renewal and generate new blood cells for ...
13
Polycomb group proteins and their functions: A review
... It was reported [6] that EZH2 played an important role in the evolution process of human prostate cancer. EZH2 gene located on chromosome 7 q35 position, the gene in the genome structure covered nearly 40 KB, contained20 ...
5
Spen limits intestinal stem cell self-renewal
... of stem cell self-renewal and differentiation properties is essential for tis- sue ...trolling stem cell properties, we identify the gene split-ends (spen) in a genetic screen as a ...
31
Exploring cell-substrate interactions in stem cell self-renewal and differentiation
... Since cell spreading, stimulated by ECM components promotes ESC differentiation by the activation of integrin signalling pathways 97 and conversely, the reduction of cell-substrate contacts promotes ...
171
Lgr proteins in epithelial stem cell biology
... Lgr stem cell markers and their R-spondin ligands has had a major beneficial impact on our understanding of stem cell biology in a range of rapidly renewing ...adult stem cells and the ...
11
Control of germline stem cell differentiation by Polycomb and Trithorax group genes in the niche microenvironment
... PcG proteins can act as either oncogenes or tumor suppressors, which probably depends on tissue context and the identity and function of their target genes in the designated cell ...non ...
10
Polycomb group genes are required for neural stem cell survival in postembryonic neurogenesis of Drosophila
... neural stem cell survival in postembryonic neurogenesis of Drosophila Bruno Bello*, Niklaus Holbro and Heinrich Reichert Genes of the Polycomb group (PcG) are part of a cellular memory system that ...
9
Control of self-renewal and cell fate in Drosophila neural stem cell lineages
... 96 5.3. DISCUSSION 5.3.1. Summary CG6049/barc was originally identified as an overproliferation gene in a recent neuroblast genome-wide RNAi screen (Neumuller et al., 2011). In this study, we have shown that barc encodes ...
127
RASSF1C modulates the expression of a stem cell renewal gene, PIWIL1
... Methods: Over-expression and siRNA techniques were used to alter RASSF1C expression in human lung cancer cells, and Affymetrix-microarray study was conducted using NCI-H1299 cells over-expressing RASSF1C to identify ...
10
mTORC1 is essential for leukemia propagation but not stem cell self renewal
... and Stem Cell Research Program, Cancer Research Institute, Kanazawa University, Kanazawa, ...B cell development but did not alter survival or proliferation of hematopoietic progenitor ...control ...
17
A Regulatory Network of Drosophila Germline Stem Cell Self-Renewal
... control stem cell self-renewal in both ...as cell division, growth regulation, or splicing are commonly required in GSCs and ...self- renewal (Neumu¨ller et ...in stem ...
15
Control of neural stem cell self-renewal and differentiation in Drosophila
... neural stem cells of Drosophila, called neuroblasts, have the ability to self-renew and at the same time produce many different types of neurons and glial ...asymmetric cell division mode in which the ...
44
Role of stem cell proteins and microRNAs in embryogenesis and germ cell cancer
... Embryonic stem (ES) cells are pluripotent cells derived from the inner cell mass of the ...all cell lineages. Germ cell cancers (GCC) mimic embryonic development to a certain ...specific ...
14