Positive inotropic
Evaluation of Positive Inotropic Activity Induced bya Danazol Derivative in Isolated Rat Heart Model
... Several reports which indicate that congestive heart fail- ure (CHF) is a main cause of death in patients with heart disease [1,2]. For the treatment of CHF has been several drugs such as the digitalis glycosides, ...
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The Positive Inotropic and Chronotropic Effects of Teucrium Polium L. Extract on Guinea Pig Isolated Heart
... and inotropic effects of TP. The results show positive choronotropic effects of aqueous-ethanol extraction of ...show positive inotropic effects of aqueous-ethanol extract of ...
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Positive inotropic and vasodilator actions of milrinone in patients with severe congestive heart failure Dose response relationships and comparison to nitroprusside
... potent positive inotropic and vascular smooth muscle-relaxing agent in vitro, and therefore, it is not known to what extent each of these actions contributes to the drug's hemodynamic effects in patients ...
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REVISITING CARDIOPROTECTIVE ROLE OF CURCUMINOIDS: A COMPARISON OF CARDIAC OUTPUT, POSITIVE INOTROPIC, AND NEGATIVE CHRONOTROPIC EFFECTS IN ISOLATED PERFUSED FROG HEART PREPARATION
... Curcuminoids, a curcumin (C), demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC) were isolated from Curcuma longa L. (C. longa L) by column chromatography and evaluated for relative cardioprotective potential in ...
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Myocardial energy production and consumption remain balanced during positive inotropic stimulation when coronary flow is restricted to basal rates in rabbit heart
... to inotropic or rate stimulation in the presence of restricted flow reserve and are inconsistent with the concept of "demand-induced" or "relative" myocardial ...
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Monoamines and the isolated auricle of sepia officinalis: are there β like receptors in the heart of a cephalopod?
... strong positive inotropic reactions (Kling, 1985; Kling and Schipp, 1987), serotonin not only increased the contraction force ...(P<0.05) positive inotropic and chronotropic effects ...
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Evaluation of Inotropic Activity of Fluorobenzene Derivative Using an Isolated Rat Heart Model
... induce positive inotropic activity in rat vascular smooth muscle via nitric oxide synthase inhibition ...induce inotropic effects in the cardiovascular system; however, there are few reports on the ...
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The inotropic effects of ammonia on isolated perfused rat hearts and the mechanisms involved
... The mechanisms involved in the NH3-induced positive inotropic effect may be related to the ATP-sensitive K+ KATP channel and the nitric oxide NO–cyclic GMP cGMP signaling pathway.. In ad[r] ...
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The effect of chronic digitoxin administration on the contractile state of normal and nonfailing hypertrophied myocardium
... significantly reduced mortality from heart failure and enhanced the recovery of contractile function; contractile function in the 6 wk banded treated group approached that of untreated control and 24-wk banded groups. ...
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Enkephalins increase cyclic adenosine monophosphate content, calcium uptake, and contractile state in cultured chick embryo heart cells
... the inotropic response of spontaneously beating cultured chick embryo ventricular cells to the enkephalin analogue ...this positive inotropic effect was investigated by examining alterations in 45Ca ...
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Activation of myocardial adenyl cyclase by histamine in guinea pig, cat, and human heart
... the positive inotropic and chronotropic effects of other hormones on the heart are thought to be mediated by cyclic 3¢,5¢-AMP, we examined the effect of histamine on adenyl cyclase in particulate ...
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The negative inotropic effect of beta3 adrenoceptor stimulation is mediated by activation of a nitric oxide synthase pathway in human ventricle
... cal positive inotropic (and chronotropic) action of catechol- amines in the heart, at least at concentrations likely to be generated endogenously within ventricular ...
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Beta3 Adrenoceptor in the eel (Anguilla anguilla) heart: negative inotropy and NO cGMP dependent mechanism
... negative inotropic effects (Gauthier et ...produce positive inotropic actions (Arch and Kaumann, 1993; Sennit et ...negative inotropic effect has been attributed to an action mechanism that ...
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Sex dependent effects of gonadal steroids and cortisol on cardiac contractility in rainbow trout
... the positive inotropic effects of steroids on the trout ...the positive inotropism induced with epinephrine was completely additive to the actions of sex steroids and ...
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Pharmacology and inotropic potential of forskolin in the human heart
... potent positive inotrope in failing human myocardium, producing a stimulation of contraction that was similar to ...a positive inotropic agent that reduced preload and ...
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Gentamicin blockade of slow Ca++ channels in atrial myocardium of guinea pigs
... dependence of myocardial fibers on influx of Ca++ through specific "slow channels" of the sarcolemma), the cardiac depressant activity of gentamicin (0.1 mM) was profoundly augmented. Conversely, the negative ...
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Pertussis toxin sensitive G proteins influence nitric oxide synthase III activity and protein levels in rat heart
... hibition on resting peak 1 dP/dt (5, 24, 30). This discrepancy may be explainable by observations that NO may have a bi- phasic effect on contractility and L-type calcium currents (6), having positive ...
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Cardiotonic activity of Petrolium Ether and alcoholic extract of Seeds of Cassia Tora Linn.
... for positive inotropic and negative chronotropic ...produced positive inotropic and chronotropic ...with positive inotropic effect and ...showed positive inotropic ...
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Rainbow trout myocardium does not exhibit a slow inotropic response to stretch
... Mammalian myocardial studies reveal a biphasic increase in the force of contraction due to stretch. The first rapid response, known as the Frank–Starling response, occurs within one heartbeat of stretch. A second ...
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Functional beta3 adrenoceptor in the human heart
... a positive inotropic effect (peak tension in- creased by ...the positive inotropic response to norepinephrine (peak tension decreased by ...negative inotropic effects, demonstrating ...
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