Positive regulator
A genome-wide RNAi screen identifies MASK as a positive regulator of cytokine receptor stability
... Consistent with the decrease in levels and dimerisation of receptor, we also found that Upd-induced JAK/STAT transcriptional activation was reduced following knockdown of MASK, both at the level of a luciferase-based ...
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Cytomegalovirus Encodes a Positive Regulator of Antigen Presentation
... the positive regulator m04 that in turn is balanced by the negative regulator m06, is ...the positive regulator m04 is of any relevance at ...master regulator of mCMV antigen ...
12
A novel role for protein tyrosine phosphatase 1B as a positive regulator of neuroinflammation
... PTP1B is expressed in many tissue types including skeletal muscle, liver, adipocytes, and brain [40]. PTP1B upregulation in obese and diabetic animals and humans has been reported in many studies [49–52]. It is well ac- ...
14
Bluetongue virus non structural protein 1 is a positive regulator of viral protein synthesis
... Importantly, the type of transcripts upregulated by NS1 does not extend to the Rluc(A)n mRNA which lacks viral sequences and has a typical cellular 3 0 poly(A) tail, demon- strating that NS1 is not a general upregulator ...
11
The E3 ubiquitin ligase RNF121 is a positive regulator of NF-κB activation
... Figure 1 Participation of RNF121 in TNFR-mediated NF- κ B activation. (A) NF- κ B reporter luciferase assay screen of a siRNA library targeting 46 transmembrane E3 ubiquitin ligases (2 siRNAs/target) in HEK293T cells. ...
7
CARP, a Myostatin-downregulated Gene in CFM Cells, Is a Novel Essential Positive Regulator of Myogenesis
... as a negative regulator of muscle growth and inhibits CARP expression; we postulated that CARP might exert positive effects on skeletal muscle development. To explore the function of CARP in the growth of ...
12
Pepsin is a positive regulator of Ac cathB 2 involved in the rat gut penetration of Angiostrongylus cantonensis
... this positive effect by incubating L3 with the positive serum confirmed that gastric acid positively affected intestinal penetration, and the impact was partially attributed to the activation of ...
10
Neurokinin-1 receptor is a novel positive regulator of Wnt/ β-catenin signaling in melanogenesis
... human mealocytes with Wnt/β-catenin inhibitor XAV939 or siβ-catenin. Results showed that Wnt/β-catenin inhibition by XAV939 blocked SMSP-induced elevation of melanin content and TYR activity. It is well known that skin ...
13
Protein phosphatase 4 is an essential positive regulator for Treg development, function, and protective gut immunity
... Lastly, qPCR was performed using genomic DNA from sorted splenic CD4 + Foxp3- GFP + cells to assess the efficiency of ppp4c deletion in the CD4cre:PP4 f/f :Foxp3-GFP + mice; the results [r] ...
14
Proteolytic Activation of Rim1p, a Positive Regulator of Yeast Sporulation and Invasive Growth
... In the yeast Saccharomyces cerevisiae, riml, 8, 9, or 13 mutations cause four phenotypes: poor growth at low temperature, altered colony morphology, inefficient sporulation due [r] ...
11
SUM1, AN APPARENT POSITIVE REGULATOR OF THE CRYPTIC MATING-TYPE LOCI IN SACCHAROMYCES CEREVISIAE
... specifically affects the activity or expression of the a1 gene product. Accordingly, in the a a a marl suml strain, the expression of all cassettes may be reduced [r] ...
14
The Cellular Factor NXP2/MORC3 Is a Positive Regulator of Influenza Virus Multiplication
... NXP2 Requirement for Influenza A Virus Transcription MORC3 is a nuclear matrix protein 15 that associates with viral RNPs, we set out to test whether the synthesis of viral RNAs was affec[r] ...
9
Apelin is a positive regulator of ACE2 in failing hearts
... potent positive inotro- pic activity (1, ...independent positive inotropy and increases coronary blood flow by vascular dilation, thereby providing beneficial effects in failing hearts (1, 2, 8, ...
10
Gtpbp2 is a positive regulator of Wnt signaling and maintains low levels of the Wnt negative regulator Axin
... a positive control, we designed a morpholino against the Ring Finger 146 ubiquitin ligase (Rnf146), knockdown of which has been demonstrated to stabilize Axin levels in cultured mam- malian cells [19, ...
12
Brassinosteroids Act as a Positive Regulator of Photoprotection in Response to Chilling Stress
... Brassinosteroids (BRs) are the class of steroid plant hormones that play important roles in plant growth, development and stress responses. BRs are perceived by a leucine-rich repeat receptor-like kinase BRASSINOSTEROID ...
50
Human epithelial type ovarian tumour marker beta 2 microglobulin is regulated by the TGF β signaling pathway
... B2M acted as a positive regulator in the proliferation, migration and invasion of OC cells and was regulated at mRNA and protein levels by the TGF-β signaling pathway, indicating a possi[r] ...
13
Original Article Long non-coding RNA H19 mediates ovarian cancer cell cisplatin-resistance and migration during EMT
... EMT positive regulator, twist, slug, snail mRNA, and protein in OVCAR3/DDP were dramatically up-regulated compared with the OVCAR3 group, and the expressions of the EMT negative regulator, E-cadherin ...
10
Disease Expression in Autosomal Recessive Retinal Dystrophy Associated With Mutations in the DRAM2 Gene
... Although the exact role of DRAM2 remains to be determined, previous work has suggested that it acts as a positive regulator of autophagy.6 It is of interest that hydroxychloroquine, an a[r] ...
8
PakD, a Putative p21-Activated Protein Kinase in Dictyostelium discoideum, Regulates Actin
... provide evidence that PakD is a positive regulator of starvation- induced and cAMP-induced cytoskeletal changes and is required for development, regulation of membrane extensions, effici[r] ...
8
The Constitutive, Glucose-Repression-Insensitive Mutation of the Yeast MAL4 Locus Is an Alteration of the MAL43 Gene
... It is interesting to note that sequence analysis of a dominant mutation of the ADRl gene, which encodes a positive regulator controlling the glucose sensitive expression [r] ...
9