Posttranscriptional Regulation
Posttranscriptional Regulation of the Yersinia pestis Cyclic AMP Receptor Protein Crp and Impact on Virulence
... In particular, Y. pestis has adapted to a lifestyle in which it is thought to exist predominantly as a parasite—the plague bacillus cycles between infection of an arthropod vector and a mammal and is not believed to ...
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The Canonical Immediate Early 3 Gene Product pIE611 of Mouse Cytomegalovirus Is Dispensable for Viral Replication but Mediates Transcriptional and Posttranscriptional Regulation of Viral Gene Products
... Transcription of mouse cytomegalovirus (MCMV) immediate early ie1 and ie3 is controlled by the major immediate early pro- moter/enhancer (MIEP) and requires differential splicing. Based on complete loss of genome ...
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Tribbles 1 regulates hepatic lipogenesis through posttranscriptional regulation of C/EBPα
... development of coronary artery disease in humans; however, it is not clear how its protein product tribbles-1 regulates lipid metabolism. Here, we evaluated mice harboring a liver-specific deletion of Trib1 (Trib1_LSKO) ...
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Posttranscriptional regulation of pineal melatonin synthesis in Octodon degus
... Degus (Octodon degus) belong to the infraorder Hystric- ognathi and are distinct from the members of Myomorpha suborder that include nocturnal rodents such as laboratory rats, mice, hamsters, and diurnal rodents ...
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Posttranscriptional Regulation of HIV 1 Gene Expression during Replication and Reactivation from Latency by Nuclear Matrix Protein MATR3
... ABSTRACT Posttranscriptional regulation of HIV-1 replication is finely controlled by viral and host ...the posttranscriptional level have been greatly overlooked in favor of transcrip- tional ...the ...
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Transcriptional and posttranscriptional regulation of tumor necrosis factor gene expression in human monocytes
... exposure. The protein synthesis inhibitor, cycloheximide (CHX), had no detectable effect on levels of TNF transcripts in resting monocytes, while this agent superinduced the level of TNF mRNA by 50-fold in TPA-activated ...
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Mouse Cytomegalovirus MicroRNAs Dominate the Cellular Small RNA Profile during Lytic Infection and Show Features of Posttranscriptional Regulation
... MicroRNAs (miRNAs) are small, noncoding RNA molecules that regulate gene expression at the posttranscriptional level. Originally identified in a variety of organisms ranging from plants to mammals, miRNAs have ...
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The Adenovirus L4-22K Protein Has Distinct Functions in the Posttranscriptional Regulation of Gene Expression and Encapsidation of the Viral Genome
... other posttranscriptional mecha- nisms, is not surprising given that the L4-22K mRNA is nearly identical to the L4-33K mRNA, with the exception of the internal intron of ...
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Posttranscriptional regulation of a class of human cytomegalovirus phosphoproteins encoded by an early transcription unit.
... To more accurately determine the temporal pattern of accumulation of the transcripts encoding this family of proteins and to correlate each with their proposed protein product, we analyz[r] ...
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RNA binding protein ZFP36L1 maintains posttranscriptional regulation of bile acid metabolism
... a posttranscriptional mechanism that requires hepatic FXR but is independent of the transcriptional repres- sor ...a posttranscriptional mechanism, a hypothesis supported by our in vitro reporter gene ...
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Transcriptional and posttranscriptional regulation of class I major histocompatibility complex genes following transformation with human adenoviruses.
... Tumorigenicity of hamster and mouse cells transformed by adenovirus type 2 and 5 is not influenced by the level of class I major histocompatibility antigens expressed on the cells.. The [r] ...
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Inhibition of lung epithelial cell proliferation by hyperoxia Posttranscriptional regulation of proliferation related genes
... The regulation of T2 cell proliferation and the effect of reactive oxygen (O2) species on this lung cell proliferation have not been well ...the regulation of two late cell cycle genes, histone and ...
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Posttranscriptional regulation of beta interferon expression in erythroid Friend cells treated with gamma interferon.
... With respect to IFN-P induction, IFN--y appears unable to induce IFN-f production in HeLa cells, in which constitutive transcription of the IFN-P gene is undetectable before and after IF[r] ...
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MicroRNA-328 enhances cellular motility through posttranscriptional regulation of PTPRJ in human hepatocellular carcinoma
... ( B ) Loss of PTPRJ could significantly attenuate the effects of miR-328 inhibitor on cell migration and invasion of both sMMc-7721 and Bel-7402 cells (* P , 0.05).. Abbreviations: PTPr[r] ...
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Adaptation to supraphysiologic levels of insulin gene expression in transgenic mice: evidence for the importance of posttranscriptional regulation
... oligonucleotides specific for mouse insulins I and II or for human insulin, showed that the excess insulin mRNA was due solely to expression of the foreign, human insulin gene. The ratio of mRNA for mouse insulin I and ...
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Transcriptional and Posttranscriptional Regulation of Cytokine Gene Expression in HIV-1 Antigen-Specific CD8+ T Cells That Mediate Virus Inhibition
... The ability of CD8 ⴙ T cells to effectively limit HIV-1 replication and block HIV-1 acquisition is determined by the capacity to rapidly respond to HIV-1 antigens. Understanding both the functional properties and ...
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Overexpression of miR-1 in the heart attenuates hippocampal synaptic vesicle exocytosis by the posttranscriptional regulation of SNAP-25 through the transportation of exosomes
... Results: Compared with the levels in age-matched WT mice, miR-1 levels were increased in both the hearts and hippocampi of Tg mice, accompanied by the redistribution of SVs and the reduc[r] ...
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Expression of ras oncogenes in cultured human cells alters the transcriptional and posttranscriptional regulation of cytokine genes
... mutations in ras protooncogenes have been detected in human tumors, as well as evidence linking ras gene products to activation of certain cellular functions, we investigated whether ras mutations might influence the ...
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Posttranscriptional regulation of hepatitis B virus replication by the precore protein.
... Hepadnaviruses encode two core-related open reading frames. One directs the synthesis of the p21 core protein, which subsequently becomes a structural component of the viral nucleocapsid. The other produces a p25 precore ...
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Posttranscriptional Control of Microbe Induced Rearrangement of Host Cell Actin
... on posttranscriptional regulation by two small RNAs (sRNAs), GlmY and ...and posttranscriptional biology, thus far, only one target and one mechanism of action (exposure of the ribosome binding site ...
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