potassium channel
Potassium Channel and Glioma
... controlling potassium flow across cell ...conduct potassium ions across the membrane down their electrochemical ...different potassium channel subtypes are differentially expressed in glioma ...
6
In silico structure analysis of potassium channel Bgk toxin and its docking prediction with human voltage gated potassium (Kv) channel
... Docking is a method which predicts the favored orientation of one molecule to a second when bound to each other to form a stable complex [22]. Knowledge of the favored orientation in turn may be applied to predict the ...
9
The effect of ATP sensitive potassium channel modulation on heart rate in isolated muskrat and guinea pig hearts
... ATP-sensitive potassium channel activation and extracellular accumulation of potassium ions, hydrogen ions and ...applied potassium than were guinea pig ...extracellular potassium ...
18
Impact of aging on calcium influx and potassium channel characteristics of T lymphocytes
... Lymphocyte potassium channel inhibition had no effect in ...lymphocyte potassium channel function, important regulators of calcium influx kinetics, seems to develop with aging into adulthood, ...
7
An investigation of the biochemical interaction between subunits of the ATP-sensitive potassium channel
... deoxycholate and Triton X-100; Gilead et. al., 1975) if problems are observed with non-specific co-immunoprecipitation, as it will break all but the strongest protein- protein interactions. However, it is a fine balance ...
302
An investigation into the combination of nifedipine with potassium channel openers as potential tocolytic therapy for preterm labour; and a novel potassium channel blocker as potential therapy for post partum haemorrhage
... avoided. This would be vital to establishing any possible clinical relevance of drug combinations and would need to take into consideration the influence of endothelial- mediated response to these agents. Previous ...
263
Flow activates an endothelial potassium channel to release an endogenous nitrovasodilator
... specific potassium channel to induce the release of nitric oxide, endothelial cells cultured on micro-carrier beads were added to a flow chamber containing a vascular ring without ...a potassium ...
10
Kinetic modeling of ion conduction in KcsA potassium channel
... a potassium channel of known structure that shows both high conduction rates and selectivity among monovalent ...this channel that assumes rapid ion transport within the filter has recently been ...
8
Excessive Blinking and Ataxia in a Child With Occult Neuroblastoma and Voltage-Gated Potassium Channel Antibodies
... gated potassium channel complex antibodies were detected in ...voltage-gated potassium channel complex autoimmunity has not been described previously in the setting of neuroblastoma, it is ...
7
Overexpression of a human potassium channel suppresses cardiac hyperexcitability in rabbit ventricular myocytes
... Adenovirus vector construction. The HERG adenovirus vector was engineered and constructed following established methods (24). Briefly, the full-length coding sequence of the HERG potassium channel (2–4) ...
9
Kcnq 1-5 (Kv7.1-5) potassium channel expression in the adult zebrafish
... kcnqx potassium channel transcripts in zebrafish (Danio rerio) remains to be fully characterized although some genes have been mapped to the ...kcnqx channel transcripts is similar to that found in ...
11
An overview of the potassium channel family
... Membrane topologies and main features of the K v and K ir potassium channel subtypes. (a,b) Schematic representation of the membrane topology of (a) K v and (b) K ir channels. Note that one subunit of the ...
5
Neuronal potassium channel openers in the management of epilepsy: role and potential of retigabine
... Despite such a wide therapeutic armamentarium, it is currently estimated that about 30% of epileptic patients do not receive satisfactory treatment; this figure is even higher if one considers partial epilepsies in which ...
12
Expression of a poriferan potassium channel: insights into the evolution of ion channels in metazoans
... The authors thank Kenneth Kosik (University of California-Santa Barbara) for sharing sponge ion channel sequences at an early stage in this project. We are also grateful to Henry Sackin (The Chicago Medical ...
7
The Eag potassium channel as a new prognostic marker in ovarian cancer
... gated potassium (K + ) channels have recently generated great interest due to their involvement in cell prolifera- tion in various cancers ...+ channel block- ers have been shown to inhibit proliferation of ...
8
The synthesis of ligands for the large conductance calcium activated potassium channel
... the channel it is probable that Slip reduces the current by reducing the number o f B K channels in the cell m e m b r a n e ^ I t has been shown that processing o f BK channels subsequent to protein synthesis is ...
191
The potassium channel KCa3.1 constitutes a pharmacological target for astrogliosis associated with ischemia stroke
... (TRPV4) channel is widely expressed in the CNS, with demonstrated function not only in neurons and astro- cytes but also in endothelial cells of cerebral arteries ...TRPV4 channel reduced the dam- age to ...
15
Identification of a Basolateral Membrane Potassium Channel from Teleost Intestinal Epithelial Cells
... Single-channel current records from a basolateral membrane K+ channel in an excised, inside-out membrane patch bathed in 35 mmol I"1 K+ G35MES+0.5 2 +2 mmol I"1 Ca 2+ at Vm=0 and — 70mV[r] ...
20
Structural characterisation of recombinant and synthetic voltage-gated potassium channel domains
... facilitate channel inactivation, but it is proposed with some certainty to incorporate, probably amongst other channel domains, the loop between the putative 84 and 85 membrane- spanning helices (the 84-5 ...
369
Action Potentials in Rhodnius Oocytes: Repolarization is Sensitive to Potassium Channel Blockers
... These increases in overshoot and duration of APs in barium salines suggest that barium might not only permeate through calcium channels, but might also block a voltage-dependent potassiu[r] ...
14