Potassium oxonate
Lipidomics coupled with pathway analysis characterizes serum metabolic changes in response to potassium oxonate induced hyperuricemic rats
... Methods: Lipidomics-a specialized study of lipid metabolites-has become a highly sensitive and powerful tool for biomarker discovery. In this work, an ultra-performance liquid chromatography-quadruole-time-of-flight ...
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Antioxidative phytochemicals from Rhododendron oldhamii Maxim leaf extracts reduce serum uric acid levels in potassium oxonate induced hyperuricemic mice
... Results: Six phytochemicals, including (2R, 3R)-epicatechin (1), (2R, 3R)-taxifolin (2), (2R, 3R)-astilbin (3), hyposide (4), guaijaverin (5), and quercitrin (6), were isolated using the developed screening method. Of ...
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Effects of ChondroT on potassium Oxonate induced Hyperuricemic mice: downregulation of xanthine oxidase and urate transporter 1
... In the present study, we demonstrated that ChondroT, a new complex herbal medication reduced serum UA in hyperuricemic mice by downregulating XOD activity and renal mURAT1. Because XOD and URAT1 are im- portant targets ...
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Effects of Aquilaria Crassna on Xanthine Oxidase Activity In Vitro and Hyperuricemic Mice
... Antihyperuricemic effect Aquilaria crassna leaf extract has been commercially advertised to markedly reduce uric acid level after drinking with hot water in Thailand, whereas its experimental evidence has not been ...
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Anti Hyperuricemic, Anti Inflammatory and Analgesic Effects of Siegesbeckia orientalis L Resulting from the Fraction with High Phenolic Content
... on oxonate-induced hyperuricemia rats, and serum uric acid levels were measured by the phosphotungstic acid ...of potassium oxonate (p < ...
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Antihyperuricemic and xanthine oxidase inhibitory activities of Silymarin in a rat gout model
... groups were administered with oral treatments of the vehicle, allopurinol and silymarin solutions by oral gavage 1 h after the administration of potassium oxonate, once a day for 7 consecutive days of ...
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Journal of Applied Pharmaceutical Science
... Experiments were performed on adult male mice from the Pasteur Institute of Algeria weighing 25-30 g. They were kept under standardized conditions (temperature 21-24 °C and a light/dark cycle of 12 hours/12 hours) and ...
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Traditional Uighur Medicine Karapxa decoction, inhibits liver xanthine oxidase and reduces serum uric acid concentrations in hyperuricemic mice and scavenges free radicals in vitro
... Xanthine and XO were purchased from Sigma (St. Louis, MO, USA). Potassium oxonate was purchased from Aldrich Inc. 2, 2-diphenyl-1-picrylhydrazyl (DPP•), sodium nitro- prusside, N-(1-Naphthyl) ...
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The Effectiveness of Indonesian Tradional Therapy from Blimbing Wuluh Leaf Extract in Reducing Uric Acid in Mus Musculus
... Animal Ethics : As the experimental animals used as research subjects, healthy male mice weighing 20-30 g, aged three to four months, were used. Each group consisited of 7 mice, which were adapted for a week before ...
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PHARMACOLOGICAL EFFECT OF FICUS BENGHLENSIS LEAF EXTRACT ON SERUM URATE LEVELS AND VARIUS PARAMETER IN OXONATE INDUCED HYPERURICEMIC ANIMALS
... Administration of the uricase inhibitor, potassium oxonate resulted in significant (P<0.01) hyperuricaemic in rat, as indicated by an increase in the serum uric acid levels when compared to the control ...
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FORMULATION AND IN VITRO EVALUATION OF MUCOADHESIVE BUCCAL TABLET OF LOSARTAN POTASSIUM USING SYNTHETIC AND NATURAL POLYMERS
... Losartan potassium is an angiotensin II receptor (type AT1) antagonist. The Losartan is an orally active agent that undergoes substantial first-pass metabolism by cytochrome P450 enzymes. The Losartan is freely ...
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Development of a method to characterise the expression profile of electrogenic transmembrane proteins in excitable cells
... The hERG (the human ether-` a-go-go-related Gene), or the KCNH2 gene, encodes a protein known as Kv11.1 potassium ion channel. This channel is voltage-gated with inwardly rectification properties. According to ...
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WHY AND HOW ARE CHILDREN FAT?
... values for the fat (low potassium content) and for the lean body mass (high potassium. content) compartments of the body[r] ...
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Large Scale Process to Prepare Highly Pure Bosentan Monohydrate
... 4, 6- dichloro-5-(2-methoxybenzyl)-2,2-bipyrimidine 2 (10 g, 0.0285 moles) and anisole(750ml)were placed in a reaction flask. Potassium carbonate (34 g, 0.246 moles) was added and reaction mass was stirred for 15 ...
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Potassium tetrachlorogallate
... Data collection: KappaCCD Software Nonius, 1997; cell re®nement: HKL SCALEPACK Otwinowski & Minor, 1997; data reduction: DENZO and SCALEPACK Otwinowski & Minor, 1997; programs used to so[r] ...
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An extrarenal mechanism of potassium adaptation
... extra potassium removed from the extracellular fluid by adapted rats was not lost into the gastrointestinal ...plasma potassium after acute potassium loads by adapted rats is due to enhanced uptake ...
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(18 Crown 6 κ6O)potassium 2,4 dinitrophenolate 2,4 dinitrophenol
... a potassium and half a hydrogen ion, each lying on inversion ...The potassium ion lies in the plane of the 18-crown-6 molecule, with K—O distances ...the potassium is completed by O9 and O9′(-x, 1 - ...
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Investigations to Improve Biodiesel Yield from High Free Fatty Acid Feedstock
... of potassium hydroxide and potassium carbonate is investigatedwith the objective to maintain good catalyst activity while avoiding detrimental effects of residual water in the reaction ...
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Synthesis of methyl laurate catalyzed by bronsted acid ionic liquids
... 1 2 where c : concentration of potassium hydroxide standard solution, moL/L; V1 : sample consumption of potassium hydroxide solution volume, mL; V2 : blank test using potassium hydroxide[r] ...
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Analgesic and micromeritic evaluations of SRMS-based oral lipospheres of diclofenac potassium
... solidified reverse micellar solutions. Solidified reverse micellar solutions-based lipospheres were formulated by melt homogenization techniques using Ultra-Turrax homogenizer, and thereafter lyophilized to obtain ...
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