potassium voltage-gated channel
Structural characterisation of recombinant and synthetic voltage-gated potassium channel domains
... the channel protein, in a “ball and chain” ...B channel was shown to be ablated by trypsin treatment, and the N-terminal region in particular was shown to contain several possible trypsin cleavage sites ...
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Silencing of voltage-gated potassium channel K 9.3 inhibits proliferation in human colon and lung carcinoma cells
... concurrently in parvalbumin-containing neurons of schizophrenia patients [6], other studies have indicated divergent patterns of K V 2.1 and K V 9.3 expression. For example, in an analysis of the expression of ...
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Molecular cloning of a glibenclamide sensitive, voltage gated potassium channel expressed in rabbit kidney
... encode voltage-gated potassium channels ...predominant potassium conductance of the kidney medullary cell line GRB-PAP1 is composed of Shaker-like potassium ...Shaker-related ...
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Voltage-Gated Potassium Channel KV1.5 Protects against MPP+ Mediated Neurotoxicity in PC12 Cells
... that voltage-gated potassium channel (Kv) played significant roles in cellular signaling in both excitable and non-excitable ...important voltage-gated K + channel, which ...
6
Limbic Encephalitis Associated with Voltage Gated Potassium Channel Complex Antibodies: Patient Report and Literature Review
... Background: The family of disorders associated with antibodies against neu- ronal surface antigens is a rapidly expanding category of autoimmune neuro- logic disease. Methods: Clinical and laboratory findings of a ...
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Multicentric Castleman’s disease with voltage-gated potassium channel antibody-positive limbic encephalitis: a case report
... The constellation of subacute encephalopathy, temporal lobe seizures, and mild lymphocytic CSF pleocytosis raised the possibility of autoimmune encephalitis. Serological analysis revealed elevated ...
5
Neurological diseases associated with autoantibodies targeting the voltage-gated potassium channel complex: immunobiology and clinical characteristics
... Voltage‑gated potassium channels (VGKCs) represent a group of tetrameric signaling proteins with several functions, including modulation of neuronal excitability and neurotransmitter ...the ...
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Autoimmune encephalitis: a case series and comprehensive review of the literature
... described including anti-LGI1 encephalitis previously termed anti-voltage-gated potassium channel ‘‘anti-VGKC’’ antibody encephalitis and antiN-methyl-D-aspartic acid receptor anti-NMDAR[r] ...
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Hypoxic pulmonary vasoconstriction: role of voltage-gated potassium channels
... of potassium channels is a physiologic mecha- nism for reversing hypoxia-induced membrane depolariza- tion, and thereby reversing depolarization-induced ...Synthetic potassium channel openers have ...
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The role of voltage-gated potassium channels in the regulation of mouse uterine contractility
... BK channel expression in myometrium in a number of species [11], and the expression of BK may be regulated by the hormo- nal environment and/or reproductive state of the animal ...
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Molecular basis of ion permeability in a voltage gated sodium channel
... the channel (Appendix Fig S7A), again consistent with the electrophysiology ...Dehydrated potassium ions are approximately the right size to pass through the channel, but the small interaction ...
12
A missense mutation in the Kv1 1 voltage gated potassium channel–encoding gene KCNA1 is linked to human autosomal dominant hypomagnesemia
... Kv1.1 channel subunits can assemble with other Kv channel subunits to form heterotetramers ...mutated channel subunits, leading to a dominant negative effect by the ...tertiary channel ...
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MRI Findings in Autoimmune Voltage Gated Potassium Channel Complex Encephalitis with Seizures: One Potential Etiology for Mesial Temporal Sclerosis
... “voltage- gated potassium channel” or “VGKC” and “seizures,” “epilepsy,” “encephalitis” or “encephalopathy” identified 11 patients pre- senting between January 1, 2001, and June 1, 2008, ...
6
Inhibition of T Cell and Stimulation of B Cell Proliferation by Restraint Stress Mediated by Voltage Gated Potassium Channel 1 3 Expression
... regulated by a small number of ion channels, even the opening of individual ion channel [39]. It suggests that although the K + current is too low to record in lymphocytes by patch clamp, alterations of K + ...
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Immunotherapy Responsive Autoimmune Subacute Encephalitis: A Report of Two Cases
... 2]. Voltage-gated potassium channel antibody (VGKCAb)-associated encephalitis is a paraneoplastic or nonparaneoplastic disorder charac- terized by amnesia, delirium, and seizures with good ...
5
Kv1.3 In Microglia: Neuroinflammatory Determinant and Promising Pharmaceutical Target
... Microglial cells are responsible for brain immunosurveillance. These cells maintain brain homeostasis, phagocytose cellular debris, present antigens to T-lymphocytes and secrete cytokines and chemokines. Upon activation, ...
6
Proteomics identification of radiation-induced changes of membrane proteins in the rat model of arteriovenous malformation in pursuit of targets for brain AVM molecular therapy
... target potassium channels in animal tumour models and in clinical trials; they have also been used for the treatment of other diseases such as type 2 diabetes and hypertension, with minimal side effects ...with ...
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In silico structure analysis of potassium channel Bgk toxin and its docking prediction with human voltage gated potassium (Kv) channel
... or Potassium channel Bgk toxin is voltage-gated potassium (Kv) channel blocker toxin extracted from sea anemone Bunodosoma ...with voltage gated potassium ...
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Excessive Blinking and Ataxia in a Child With Occult Neuroblastoma and Voltage-Gated Potassium Channel Antibodies
... and voltage- gated potassium channel complex antibodies were detected in ...Although voltage-gated potassium channel complex autoimmunity has not been described ...
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Molecular and genetic basis of sudden cardiac death
... cause a complex phenotype including cardiac arrhythmia, syndac- tyly, and autism spectrum disorder (26). The syndrome exhibits sporadic occurrence as opposed to Mendelian inheritance, but a candidate gene survey ...
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