Potential implications for therapy
Potential implications of GRP58 expression and susceptibility of cervical cancer to cisplatin and thymoquinone-based therapy
... Conclusion In summary, the GRP58 expression level depending on the type of cell and type of drug. In this study, there was a correla- tion between expression of GRP58 protein and the cytotoxicity of cisplatin in HeLa and ...
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Identification of novel pathways of osimertinib disposition and potential implications for the outcome of lung cancer therapy
... Introduction Lung cancer is both the most common cancer, with an estimated 1.8 million new cases in 2012, and the most common cause of mortality from cancer, responsible for 1.5 million deaths in 2012 (1). Non-small ...
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Increased supraspinatus tendon thickness following fatigue loading in rotator cuff tendinopathy: potential implications for exercise therapy
... People with Achilles tendinopathy have been found to have an altered response to loading, either in the form of a smaller initial reduction in tendon thickness (5% reduc- tion vs 21% [r] ...
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Mucin (Muc) expression during pancreatic cancer progression in spontaneous mouse model: potential implications for diagnosis and therapy
... definitive proof of MUC4 overexpression as an early event in PC. In the present study, we observed that Muc4 mRNA and protein levels increased progressively from 10 weeks of age, which is when we observed the appearance ...
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Sputum Color: Potential Implications for Clinical Practice
... Third, we saw no relationship between the yield of spu- tum analysis and current antibiotic use. Patients who were taking an antibiotic were as likely as those not on antibi- otics to produce sputum of acceptable ...
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Microcirculatory alterations: potential mechanisms and implications for therapy
... Vasodilators Because local constriction-dilation is implicated in the regulation of flow and capillary recruitment and because decreased vascular density and stopped-flow capillaries may be the result of excessive ...
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Immunomodulation after ischemic stroke: potential mechanisms and implications for therapy
... adjunctive therapy to prevent and address post-stroke ...cell therapy (including with mesenchymal stem cells, bone marrow mononuclear cells, and neural stem/progenitor cells) following stroke is feasible ...
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Perilesional edema in brain metastases: potential causes and implications for treatment with immune therapy
... Methods: We analyzed tumor and edema volume in 18 non-small cell lung (NSCLC) and 18 melanoma patients with untreated brain metastases treated with pembrolizumab on a phase II clinical t[r] ...
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Short-Term Furosemide Therapy in ChronicRenal Disease; Implications of Hypomagnesiaand Potential for Improving Hyperkalaemia
... The side effect profile of short term furosemide treatment seems to be limited to electrolyte disturbances, as no other significant drug- related side effects were observed. However, even though it seems that furosemide ...
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Sensitivity of Kaposi's sarcoma associated herpesvirus replication to antiviral drugs Implications for potential therapy
... Recently it has been observed that some AIDS-KS patients treated with HIV protease inhibitors (usually in combination with HIV reverse transcriptase inhibitors) experience arrest or even regression of their KS lesions ...
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The role and mechanism of CRL4 E3 ubiquitin ligase in cancer and its potential therapy implications
... Hence, given the roles of CRL4 ligases in tumorigenesis, CRL4-mediated ubiquitination pathways possess broad prospects in intervention and prevention of carcinogenesis. Nevertheless, even so many studies of ...
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Potential Benefits of Dialectical Behavioral Therapy for Adolescents Receiving Treatment for Borderline Personality Disorder Traits: Implications for Psychiatric Nurses
... *Corresponding Author: [email protected] Copyright © 2014 Horizon Research Publishing All rights reserved. Abstract Borderline personality disorder (BPD) involves a complex constellation of symptoms including ...
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Down-regulation of vitamin D receptor in mammospheres: implications for vitamin D resistance in breast cancer and potential for combination therapy.
... In the current study, we used in vitro and in vivo approaches to examine the molecular mechanisms that regulate 1,25D sensitivity in mammospheres isolated from breast cancer cell lines. Our results indicate that ...
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Mechanisms of Acute Coronary Syndromes and Their Implications for Therapy
... the potential for antiinflamma- tory actions, in a phase 2 trial it did not reduce levels of C-reactive protein but did limit lipid core size, a characteristic that may render plaques susceptible to ...
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microRNAs and Esophageal Cancer - Implications for Pathogenesis and Therapy
... the potential to provide clinically relevant information about prognosis and potential response to chemotherapy in patients with esophageal squamous cell ...have potential for use in therapy ...
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SEXUAL DYSFUNCTION IN HYPERTENSIVE PATIENTS: IMPLICATIONS FOR THERAPY
... on therapy and lead to deterioration in patients' quality of ...the potential occurrence of these side effects with their ...antihypertensive therapy that is highly effective in lowering blood ...
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Down regulation of SPAG9 reduces growth and invasive potential of triple-negative breast cancer cells: possible implications in targeted therapy
... MDA-MB-231, BT- 474 and SK-BR-3 cells (Figure 1d), which revealed SPAG9 protein expression predominantly in cytoplasm. Further, surface localization of SPAG9 pro- tein was detected in all four breast cancer cells as dem- ...
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Potential of human PON2 as an anti pseudomonal therapy
... cell therapy, where live whole cells are administered. Cell therapy, using a variety of stem/progenitor cells and even a tissue-engineered lung may hold some promise, but this form of therapy is ...
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Biosimilars: potential implications for clinicians
... is potential for reduction in health care costs of associated bio- pharmaceuticals and the creation of a more affordable biologic ...immunogenicity potential, a required reported component for US FDA ...
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Reactivity in Psychological Therapy and the Potential for
... & Yeryomenko, 2017) to help them build aware- ness of the subjective constructive dimension of their relational experiences. The EXP is an obser- vational coding system designed to measure the degree to which clients ...
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