potential inhibitors
Virtual screening of potential inhibitors for SARS-CoV-2 main protease
... In this sense, it is still necessary to identify therapeutic agents that can rapidly be translated from the bench to the clinic, in order to benefit the patients and protect healthcare professionals that are fighting ...
18
Anomeric spironucleosides of -D-glucopyranosyl uracil as potential inhibitors of glycogen phosphorylase
... Kinetics determined that the S anomeric spirocycle 4b exhibited 1.25 times higher inhibition than the R anomer 4a. The difference could be associated with the locked syn conformation of the pyrimidine ring with regard to ...
11
Phyto-polyphenols as potential inhibitors of breast cancer metastasis
... NF-κB is a main player in the metastatic process be- cause it is crucial regulator of cell proliferation and sur- vival. NF-κB levels may predict the potential of the tumor cells to metastasize (Jin et al. 2014). ...
17
Anomeric spironucleosides of -D-glucopyranosyl uracil as potential inhibitors of glycogen phosphorylase
... compounds, inhibitors of GP that might prevent unwanted glycogenolysis under high glucose conditions and thus aim at the reduction of excessive glucose production from the liver, in the case of type 2 ...
10
Designing and Virtual Screening of Potential Inhibitors of PFHGPRT against Malaria
... Molecular docking is a safe and easy tool that helps in investigating, interpreting, explaining, identification of molecular properties using 3D structure, molecular docking is tries to used predict the structure of ...
9
Virtual Screening of potential inhibitors from Herbs for the treatment of Breast Cancer
... Methods: Complementary and alternative medicine is often used for curing cancer mainly the breast cancer. Also certain studies support the benefits of herbal medicines over others among Complementary and alternative ...
6
IDENTIFICATION OF POTENTIAL INHIBITORS FOR LOWERING CHOLESTEROL LEVEL BY INHIBITING PCSK9
... PCSK9 regulates the lifespan of the receptor on the liver that clears cholesterol. If the protein is inhibited, lower cholesterol levels are seen in several studies because the protein causes the liver receptor that ...
5
Remdesivir Derivatives as Potential Inhibitors or Ebola Virus Matrix Protein VP40
... The Ebola virus matrix protein VP40 protein was downloaded into ArgusLab program and binding site was made by choosing “Make binding site for this protein” option. The inhibitors were chosen, centered and added ...
6
Favipiravir Derivatives as Potential Inhibitors for NS3 Protease of West Nile Virus
... West Nile virus belong to Flavivirus genus, which contains numerous noteworthy human pathogens, including dengue infection, Japanese encephalitis infection and yellow fever infection, and was first isolated in 1937 from ...
6
Synthesis of New Oleilphosphonates as Potential Inhibitors of DAGL and MAGL. I PART
... The endogenous levels of 2-AG are linked to the activities of two enzymes: diacylglycerol lipase.. (DAGL) and monoacylglycerol lipase (MAGL).[r] ...
11
Synthesis of potential inhibitors of the protein A Tase
... Four new O'^-aryi-5-deazapterin derivatives w ere prepared using the M itsunobu rcacuor., \vhich only proceeds when the pterin is suitably protected at the 2-am ino position. The pivaloyl group used in this circum stance ...
156
InhA inhibitors as potential antitubercular agents
... InhA inhibitors 3D-QSAR was established using the comparative molecular field analysis (CoMFA) and docking studies were also carried out using the crystal structure of ...finding potential inhibitors ...
17
Synthesis of nodularin analogues as potential protein phosphatases inhibitors
... We proposed, that if a P-alanine was replaced by a-carboxy protected aspartate residue, this could be unmasked once cyclisation had taken place and subsequent reactions could be achieved on the free carboxylic acid to ...
248
A FACILE SYNTHESIS OF TRIAZOLOQUINAZOLINONE DERIVATIVES AS POTENTIAL Α GLUCOSIDASE INHIBITORS
... In the current study, we have selected the 6-amino [2,3]-disubstituted quinazolin-4-one as third scaffold for generation of a focused library of 8650 compounds to identify potential inhibitors of ...
34
The development prospection of HDAC inhibitors as a potential therapeutic direction in Alzheimer’s disease
... Additionally, HDAC inhibitors need to be considered in age-dependent and/or stage-dependent manner when representing as a therapeutic target for AD. The study by Noh H et al. classified the pathogenic process into ...
6
Discovery of potential xanthine oxidase inhibitors using in silico docking studies
... Molecular docking studies of allopurinol with xanthine oxidase enzyme exhibited binding interactions and warrants further studies needed for the development of potent xanthine oxidase inhibitors for the treatment ...
8
Inhibitors of ubiquitin E3 ligase as potential new antimalarial drug leads
... ligase inhibitors were also tested against Vero cells (African green monkey kidney epithelial cells) and trans- formed non-dividing human monocytic (THP1) ...
10
Synthesis and Reactivity of β Sultams with the Potential to Act as Metallo Enzyme Inhibitors
... analogue inhibitors work by mimicking the transition state of the normal ...based inhibitors for serine-β-lactamases include clavulanic acid (administered with amoxicillin, marketed as Augmentin), sulbactam ...
157
Molecular Modeling of Potential Dual Inhibitors of HIV Reverse Transcriptase and Integrase
... the potential ability of pyridinone analo- gues and related compounds to act as dual inhibitors of RT and ...dual inhibitors may be more effective than molecules directed to only one molecular target ...
41
The potential interaction between clopidogrel and proton pump inhibitors: a systematic review
... Our literature search found 54 publications, and 18 of these studies [11,12,23-38] fulfilled our inclusion criteria (see Figure 1). One study was experimental with random PPI allocation [25], while the others were ...
9