Potential therapeutic implications
Signalling processes in endothelial ageing in relation to chronic oxidative stress and their potential therapeutic implications in humans
... Signalling processes in endothelial ageing in relation to chronic oxidative stress and their potential therapeutic implications in.. humans.[r] ...
24
The human gut microbiota and virome: Potential therapeutic implications
... Fig. 1. Potential future therapeutic applications of bacteriophages in humans. Panel A: The “classic” lytic phage use as an antimicrobial, as a mono-phagic administration, has been stopped due to rapid ...
6
Immunogenicity of Botulinum Toxin Formulations: Potential Therapeutic Implications
... and therapeutic proteins, including BoNT formulations, can be recog- nized as foreign by the immune system and, therefore, have the potential for immuno- ...
19
An update on the role of prokineticins in human reproduction potential therapeutic implications
... GnRH neurons. But the presence of PROK2/PROKR2 mutations in nIHH subjects and the reproductive abnor- malities found in prok knockout mice with partial olfac- tory bulb development is suggestive a potential role ...
15
Interaction of autophagy with microRNAs and their potential therapeutic implications in human cancers
... In summary, the advantages and disadvantages of different miRNA delivery systems are listed in Table 2. Many miRNAs with the po- tential function to regulate autophagy are dysregulated in human cancers. Targeting these ...
7
Fibrosis: a key feature of Fabry disease with potential therapeutic implications
... clinical implications: a) Before starting with ERT a baseline staging of the extent of fibrosis should be obtained in all patients for adjusting outcome expecta- ...
12
The epigenetic effects of butyrate: potential therapeutic implications for clinical practice
... but also for cancer chemoprevention. In contrast to genetic defects, epigenetic aberrations can be reversible: a trait that represents a key aspect of their potential as therapeutic targets. HDACi cause ...
7
Potential therapeutic implications of new insights into respiratory syncytial virus disease
... Viral bronchiolitis is the most common cause of hospitalization in infants under 6 months of age, and 70% of all cases of bronchiolitis are caused by respiratory syncytial virus (RSV).. [r] ...
6
Characterization of acetate transport in colorectal cancer cells and potential therapeutic implications
... Acetate, together with other short chain fatty acids has been implicated in colorectal cancer (CRC) prevention/therapy. Acetate was shown to induce apoptosis in CRC cells. The precise mechanism underlying acetate ...
15
Identification of three subtypes of triple negative breast cancer with potential therapeutic implications
... [37]. Therapeutic regimens should associate different immune checkpoint inhibitors, to enhance global efficacy and cytotoxicity of chemother- apy, because immunomodulators are not directly cyto- toxic against ...
14
Role of Cholinergic Receptors in Colorectal Cancer: Potential Therapeutic Implications of Vagus Nerve Stimulation?
... cluding kinases [46]. Directly beneath TJ are the adher- ens junctions (AJ) with E-cadherin connected to the actin cytoskeleton via α/β catenins and regulated by p120ctn [47]. Disorganization of these cellular junctions ...
16
Potential therapeutic implications of IL-6/IL-6R/gp130- targeting agents in breast cancer
... Received: October 05, 2015 Accepted: January 23, 2016 Published: January 31, 2016 ABSTRACT Interleukin-6 (IL-6) is a pleiotropic cytokine with known multiple functions in immune regulation, inflammation, and oncogenesis. ...
14
Thyroid hormone is a critical determinant of myocardial performance in patients with heart failure: potential therapeutic implications
... In conclusion, changes in thyroid hormone are closely correlated to myocardial functional status in patients with heart failure. These data are in accord- ance with experimental observations that strongly support a ...
6
Caloric restriction increases ratio of estrogen to androgen receptors expression in murine ovaries - potential therapeutic implications
... In our experiment, we did not observe a decrease in the body mass of female mice after 9 months of CR. It is known that after menopause or ovariectomy in humans the decrease in estrogens is paralleled by an increase in ...
8
microRNAs in Spinal Cord Injury: Potential Roles and Therapeutic Implications
... licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited. Received: 2014.03.09; Accepted: 2014.08.01; Published: 2014.09.06 ...
10
Alternative splicing in the hippo pathway—implications for disease and potential therapeutic targets
... Keywords: Hippo pathway; alternative splicing; yes-associated protein; splice-switching oligonucleotides; gene therapy 1. Introduction The Hippo pathway is a newly established serine-threonine kinase cell signalling ...
19
POTENTIAL OF CLASSICAL AND MOLECULAR CYTOGENETICS IN THE DIAGNOSIS OF LEUKEMIA: ASSESSMENT OF THEIR CLINICAL AND THERAPEUTIC IMPLICATIONS
... Cytogenetic exploration in hematological tumor pathology is based on karyotype and fluorescent in situ hybridization (FISH), which are essential to make the diagnosis, determine the phase of the disease and also evaluate ...
5
Established and potential echocardiographic markers of embolism and their therapeutic implications in patients with ischemic stroke
... Conclusions About 80% of ischemic strokes occur in per- sons without AF, and it is therefore important to develop a path to examine the optimal preven- tion of stroke when there is no obvious AF. The benefits of oral ...
13
Therapeutic implications of osteoprotegerin
... reverse hypercalcemia in less than 3-5 days in most patients [44]. Disorders of mineral metabolism As it has been already mentioned, OPG regulates nega- tively the interaction between RANKL and its receptor RANK and ...
8
Potential Therapeutic Agents
... Protection from Aminoglycoside- Induced Ototoxicity SALICYLATE Thus far, the only agent that has undergone clinical trials for otoprotection against amino- glycoside-induced ototoxicity is high-dose as- pirin. Salicylate ...
16