POU domain
The Brn-3 POU domain transcription factors in gynaecological cancers
... The data presented here shows for the first time that, the class IV POU domain transcription factor Bm-3a is over-expressed in HPV-associated cervicai neoplasias, with implications in the aetiology of ...
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Functional equivalence of Brn3 POU domain transcription factors in mouse retinal neurogenesis
... generated. POU-domain transcription factors play pivotal roles in cell differentiation processes (Wegner et ...IV POU-domain Brn3 factors Brn3a, Brn3b and Brn3c (Pou4f1, Pou4f2 and Pou4f3, ...
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Genome wide identification of Grainy head targets in Drosophila reveals regulatory interactions with the POU domain transcription factor Vvl
... Grainy head (Grh) is a conserved transcription factor (TF) controlling epithelial differentiation and regeneration. To elucidate Grh functions we identified embryonic Grh targets by ChIP-seq and gene expression analysis. ...
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Discrete gene sets depend on POU domain transcription factor Brn3b/Brn 3 2/POU4f2 for their expression in the mouse embryonic retina
... specific POU domain transcription factor Brn3b/Brn- ...of POU domain protein function in neuronal ...a POU domain transcription factor for their ...
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Expression of POU domain transcription factor, Oct 6, in schizophrenia, bipolar disorder and major depression
... of POU factors in affective dis- orders was highlighted by a study by Stopkova et al (2004) who reported that a polymorphism within the PIK3C3 promoter, linked to a subset of schizophrenic and bipolar ...by ...
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Induced stem cell neoplasia in a cnidarian by ectopic expression of a POU domain transcription factor
... Pluripotent stem cells are undifferentiated cells that are able to contribute to all adult somatic lineages and to the germ line. They have been best studied in mammals, in which they form the inner cell mass of the ...
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Regulation and Function of POU domain transcription factors, Brn-3a and Brn-3b
... the POU domain and can occur in the absence of DNA (Voss et al, ...the POU domain proteins coded for by unc-86 and mec-3 genes bind to the mec-3 promoter cooperatively to specify neuronal ...
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The differential expression and activity of the Brn3 family of POU domain transcription factors
... entire POU domain (both POU- specific and POU-homeo domains) has been shown to be both necessary and sufficient for this cooperative interaction (Verrijzer ...a POU protein present at ...
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Transcriptional regulation by Brn-3 POU domain-containing transcription factors
... IV POU domain proteins, Bm-3a and Bm-3b (discussed in section ...The POU domain of Bm-3a generally acts as an activator of promoter constmcts bearing a Bm-3 site, while the POU ...
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POU-domain transcription factors in the developing rat nervous system
... In o rd er to make progress in understanding the role of Brn-3c (and Brn-3a) (and to determ ine w hether cells expressing these tran scrip tio n factors do indeed make connections), it will be necessary to determ ine the ...
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POU-domain factor Brn3a regulates both distinct and common programs of gene expression in the spinal and trigeminal sensory ganglia
... Numerous transcription factors have been shown to play key roles in the differentiation of brainstem, spinal, and spinal sensory neurons, yet, for the most part, the pro- grams of gene expression regulated by these ...
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Maternal control of vertebrate dorsoventral axis formation and epiboly by the POU domain protein Spg/Pou2/Oct4
... Dorsal organizer function is normal in MZspg Cognate dorsalized Bmp gene mutants show normal gene expression within the dorsal organizer, suggesting that early maternal events in DV patt[r] ...
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Specification of Drosophila motoneuron identity by the combinatorial action of POU and LIM HD factors
... combination with Isl and Lim3 to specify ISNb axon targeting. If this hypothesis is correct, than a loss of Dfr function in ISNb motoneurons should also result in a reduction in muscle innervation. To address the ...
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Regulation of gene expression by POU family transcription factors
... of POU domain genes have been documented to generate multiple isoforms through alternative ...the POU^ domain deleted has also been described(Voss et ...The POU domain genes of ...
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Developmental expression of the POU transcription factor qBrn 2 during somitic myogenesis in quail
... POU domain is a bipartite DNA binding domain, consisting of POU specific domain and POU homeodomain tethered by a variable ...discovery, POU proteins from diverse range of ...
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Sox proteins: regulators of cell fate specification and differentiation
... Fig. 4. Paradigms of developmental regulation by Sox-partner complexes. (A) Sox-partner complexes can activate cell-specific genes and their own genes, thereby stabilizing the cell state. Sox2-Pou5f1/Oct4 in ESCs is ...
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Identification of Isthmin 1 as a Novel Clefting and Craniofacial Patterning Gene in Humans
... Brand, 2002 The zebra fi sh spiel-ohne-grenzen (spg) gene encodes the POU domain protein Pou2 related to mammalian Oct4 and is essential for formation of the midbrain and hindbrain, and f[r] ...
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Wünsch, Annegret (2006): Untersuchungen zur epigenetischen Reprogrammierung nach somatischem Zellkerntransfer beim Rind mit Hilfe eines Oct4-EGFP-Reportergenkonstruktes. Dissertation, LMU München: Tierärztliche Fakultät
... In vitro development of green fluorescent protein (GFP) transgenic bovine embryos after nuclear transfer using different cell cycles and passages of fetal fibroblasts. A POU-domain tra[r] ...
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Coordinated regulation of gene expression by Brn3a in developing sensory ganglia
... the POU- domain family which is expressed in terminally differentiating neurons of the sensory peripheral nervous system and caudal ...related POU factors in neural development, these experiments ...
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Effect of Spacing and Poultry Manure Rates on Growth, Yield and Quality of Cayenne Pepper (Capsicum frutescens. L) in Southern Rain Forest of Nigeria
... Abstract – Field experiment was conducted at the Teaching and Research Farm of the Department of Agriculture, Ndele Campus, Ignatius Ajuru University of Education, Port Harcourt, Rivers State, to study the effects of ...
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