PPAR-?/? agonist
Development of PPAR-agonist GW0742 as antidiabetic drug: study in animals
... Background: The development of new drugs for the treatment of diabetes mellitus (DM) is critically important. Insulin resistance (IR) is one of the main problems associated with type-2 DM (T2DM) seen in clinics. GW0742, ...
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Long-term treatment with the pan-PPAR agonist tetradecylthioacetic acid or fish oil is associated with increased cardiac content of n-3 fatty acids in rat
... pan-PPAR agonist TTA or high-dose FO to rats, were associated with distinct effects on lipid metabolism in the heart and ...excess PPAR activation in relation to myocardial dysfunction ...
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The PPAR pan-agonist bezafibrate ameliorates cardiomyopathy in a mouse model of Barth syndrome
... In summary, the principal findings of this study are: 1) Iso exacerbates the cardiac phenotype in TazKD mice rapidly by inducing dilated cardiomyopathy and LV sys- tolic dysfunction by 4.5 months of age, and 2) the pan- ...
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Effects of the PPAR-β agonist GW501516 in an in vitro model of brain inflammation and antibody-induced demyelination
... factors, PPAR- β, also known as PPAR-δ, FAAR and NUC-1, is the pre- dominant and most widely expressed subtype in the ...particularly PPAR-β, are supposed to modulate brain cell maturation, which may ...
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PPAR-γ agonist pioglitazone affects rat gouty arthritis by regulating cytokines
... of PPAR-γ, a member of the nuclear receptor superfamily, is regulation of gene expression at the mRNA ...Activated PPAR-γ can reduce experimental rheumatoid arthritis (Cuzzo- crea et ...of PPAR-γ ...
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Effects of the PPAR-β/δ agonist GW0742 during resuscitated porcine septic shock
... specific PPAR-β/δ agonist with a chemical structure very close to that of GW0742 [1], attenuated endotoxin-induced NF- κ B activation, and cytokine release not only in rodent [24-26] but also in human tis- ...
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<p>The PPARγ Agonist Rosiglitazone Enhances the Radiosensitivity of Human Pancreatic Cancer Cells</p>
... Three PPAR subtypes have been identified, PPARα, PPARβ, and ...three PPAR subtypes share a high degree of sequence homology but differ in physiological and pharmacological functions due to their ligands ...
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<p>Treatment with a PPAR-γ Agonist Protects Against Hyperuricemic Nephropathy in a Rat Model</p>
... the PPAR- γ agonist troglitazone in a primary culture model of renal tubular epithe- lial ...34 PPAR- γ activation reduced renal fi brosis induced by per fl uorooctanesulfonate by regulating ...
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The PPAR-gamma agonist pioglitazone protects cortical neurons from inflammatory mediators via improvement in peroxisomal function
... the PPAR-g agonist pioglitazone on cortical neu- rons exposed to inflammatory mediators, and assessed whether pioglitazone influences axonal morphology and peroxisomal ...of PPAR-g and the activity ...
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Original Article The effect of PPAR-γ agonist pioglitazone promotes adhesion of endothelial progenior cells from rat bone marrow
... (PPAR-γ) agonist affects the functions of endothelial progenitor cells ...selective PPAR-γ agonist pioglitazone (PIO) on endothelial progenitor cell ...μmol/L PPAR-γagonist PIO; C: 50 ...
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In silico Studies on Plant Derived Rutin as Potent Agonist of Peroxisome Proliferator-activated Receptor Gamma (PPAR
... Aims: Peroxisome proliferator-activated receptor gamma (PPARγ) agonists are beneficial in the management of diabetes by increasing insulin sensitivity and inhibiting hepatic gluconeogenesis. The aim of the present study ...
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The peroxisome proliferator-activated receptor (PPAR) alpha agonist fenofibrate maintains bone mass, while the PPAR gamma agonist pioglitazone exaggerates bone loss, in ovariectomized rats
... and PPAR δ in bone is sparse, more is known about the sig- nificance of ...PPARg agonist pioglitazone reduces whole body BMD and causes impairment of the mechanical strength in normal female rats ...
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Different skeletal effects of the peroxisome proliferator activated receptor (PPAR)α agonist fenofibrate and the PPARγ agonist pioglitazone
... The PPAR family consists of three subtypes, PPARα, β/δ and γ (with splice variants γ 1, 2 and 3) ubiq- uitously expressed, but with a tissue specific distribution ...All PPAR subtypes have been identified ...
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The PPAR-γ agonist pioglitazone modulates inflammation and induces neuroprotection in parkinsonian monkeys
... the PPAR-g agonist would modulate the inflammatory reaction induced by the neurotoxin MPTP and, in consequence, prevent nigral cell loss and associated PD ...
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Novel Phenoxazinones as potent agonist of PPAR-α: design, synthesis, molecular docking and in vivo studies
... Fifteen new derivatives of phenoxazinone bearing sulphonamide and carboxamide pharmacophores have been described in this work. All the compounds showed good binding with PPAR alpha (2p54) with binding ener- gies ...
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Evolution in pharmacologic thinking around the natural analgesic palmitoylethanolamide: from nonspecific resistance to PPAR-α agonist and effective nutraceutical
... Soon after the breakthrough paper of Levi-Montalcini, the mast cell indeed emerged as an important target for the anti- inflammatory activity of PEA. In the period 1993–2011, at least 25 papers were published on the ...
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PPARγ agonist-loaded PLGA-PEG nanocarriers as a potential treatment for Alzheimer’s disease: in vitro and in vivo studies
... Objective: The first aim of this study was to develop a nanocarrier that could transport the peroxisome proliferator-activated receptor agonist, pioglitazone (PGZ) across brain endothelium and examine the ...
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Apoptosis rate and transcriptional response of pancreatic islets exposed to the PPAR gamma agonist Pioglitazone
... ligand-dependent PPAR-γ transcriptional activity, directly modulating the expression of genes that are not affected when islets are exposed solely to the PPAR-γ ...to PPAR-γ, but resulted from ...
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The Effect of Biochanin A as PPAR γ agonist on LDL Particles Diameter and Type 2 Diabetic Dyslipidemia
... Background and Aims: Small dense low-density lipoproteins (sd-LDL) particles are smaller and heavier than typical LDL ones. They can penetrate into the endothelium of coronary arteries more easily because of their small ...
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Evaluation of the PPAR γ agonist pioglitazone in mild asthma: a double blind randomized controlled trial
... The PPAR-γ agonists pioglitazone and rosiglitazone were developed to treat the hyperglyce- mia and insulin resistance of type 2 diabetes mellitus, and were used widely until rosiglitazone was withdrawn due to an ...
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