PPAR gamma
BERBERINE CHLORIDE INDUCED APOPTOSIS IN HEPG2 CANCER CELL LINE VIA PPAR GAMMA ACTIVATION AND COX2 INHIBITION BY REGULATING PROSTAGLANDIN E2 (PGE2) SIGNALLING PATHWAY
... follows PPAR gamma activation and COX2 inhibition by regulating PGE2 (Prostaglandin E2) signalling pathway in dose dependant manner in HEPG2 cancer cell ...
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Management of cardiac fibrosis in diabetic rats; the role of peroxisome proliferator activated receptor gamma (PPAR-gamma) and calcium channel blockers (CCBs)
... particular PPAR-gamma modula- tors, e.g., PPAR-gamma ...receptors. PPAR modulators include the PPAR-alpha, PPAR-delta (also called PPAR-beta), and ...
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Deletion of PPAR-γ in immune cells enhances susceptibility to antiglomerular basement membrane disease
... of PPAR gamma in immune cells impairs the ability of abscisic acid to improve insulin sensitivity by suppressing monocyte chemoattractant protein-1 expression and macrophage infiltration into white adipose ...
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Thermodynamics in cancers: opposing interactions between PPAR gamma and the canonical WNT/beta-catenin pathway
... cers. PPAR dysfunction influences statistical mechan- ics by modifying thermodynamic force, thermodynamic flow, and rate of entropy production [5, ...and PPAR gamma and their metabolic and energetic ...
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In silico approach for the discovery of new PPARγ modulators among plant-derived polyphenols
... hPPARs, particularly the hPPAR γ protein, have been widely studied by crystallographers, as evidenced by the 130 X-ray structures that have been deposited in the Protein Data Bank and recorded in the UniProt database ...
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PPAR[gamma]-independent mechanisms of Src kinase activation and EGFR transactivation in response to thiazolidinediones
... of PPAR -dependent target genes and allows association of the active PPAR/ RXR transcription complex (Tugwood et ...of PPAR/ RXR binding specificity (Figure ...
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Apoptosis rate and transcriptional response of pancreatic islets exposed to the PPAR gamma agonist Pioglitazone
... of PPAR-γ, Pioglitazone stimulates expression of genes that limit lipid accumulation in islets, but we cannot rule out that these changes are a response to a primary activation of lipogenic pathways, which is more ...
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Glucose-lowering effect of DLBS3233 is mediated through phosphorylation of tyrosine and upregulation of PPARγ and GLUT4 expression
... In this gene expression study, we have demonstrated that DLBS3233, a standardized herbal extract containing L. speciosa and C. burmannii, acts as an insulin sensitizer via modulation of PPAR γ . Initially, we ...
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PPAR-[gamma] ligands and adipocytes regulate expression of the plasminogen activator system in breast cancer
... of PPAR-γ in a tumor setting is unknown, our interest in PPAR-γ in breast cancer is based on literature that shows PPAR-γ regulates PAI-1 ...on PPAR-γ activation and PAI-1 alterations is ...
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Adipocyte specific Repression of PPAR gamma by NCoR Contributes to Scleroderma Skin Fibrosis
... other PPAR family members in other tissues, and is more specific to PPAR-β and PPAR-δ in muscle, in adipose tissue NCoR is PPAR-γ-specific [28, 48, ...was PPAR-γ-specific in this model, ...
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The peroxisome proliferator-activated receptor (PPAR) alpha agonist fenofibrate maintains bone mass, while the PPAR gamma agonist pioglitazone exaggerates bone loss, in ovariectomized rats
... While the information on the role of PPARa and PPAR δ in bone is sparse, more is known about the sig- nificance of PPARg. In vitro, PPARg agonists promote adipocyte differentiation preferentially over osteoblast ...
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Haplotype analysis of the PPAR gamma Pro12Ala and C1431T variants reveals opposing associations with body weight
... As predicted by the regression analysis, the effect of the haplotype on BMI was most no- ticeable and achieved significance, when the heavier indi- viduals were considered (Figure 1B, p [r] ...
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<p>The PPARγ Agonist Rosiglitazone Enhances the Radiosensitivity of Human Pancreatic Cancer Cells</p>
... Three PPAR subtypes have been identified, PPARα, PPARβ, and ...three PPAR subtypes share a high degree of sequence homology but differ in physiological and pharmacological functions due to their ligands ...
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<p>Treatment with a PPAR-γ Agonist Protects Against Hyperuricemic Nephropathy in a Rat Model</p>
... induces PPAR-γ activation in the kidneys of HN ...for PPAR-γ or glyceraldehyde 3-phosphate dehydrogenase ...of PPAR-γ were calculated by densitometry, and the ratio between PPAR-γ and GAPDH ...
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Regulation of PPAR gamma gene expression by nutrition and obesity in rodents
... of PPAR g gene expression in vivo is unknown. We cloned a partial mouse PPAR g cDNA and developed an RNase pro- tection assay that permits simultaneous quantitation of mRNAs for both g 1 and g 2 isoforms ...
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Levels of adiponectin, a marker for PPAR gamma activity, correlate with skin fibrosis in systemic sclerosis: potential utility as biomarker?
... the PPAR-g-regulated adiponectin are reduced in early-stage dcSSc and are inversely correlated with the skin ...impaired PPAR-g activity might signify unopposed fibroblast activation and serve as a ...
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Identification of PPARγ ligands with One-dimensional Drug Profile Matching
... with PPAR γ receptor agonist activity by means of screening the FDA-approved generic molecule database using oDPM ...potential PPAR γ ligands by means of the oDPM ...to PPAR γ receptor ...putative ...
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The PPAR-gamma agonist pioglitazone protects cortical neurons from inflammatory mediators via improvement in peroxisomal function
... recently, PPAR-g agonists have received considerable attention as potential therapeutic agents for a wide range of neurological diseases, including neuro- degenerative diseases, traumatic injuries, stroke and ...
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PPAR Gamma agonists regulate tobacco smoke-induced toll like receptor 4 expression in alveolar macrophages
... Some researchs showed that PPARγ expression levels was reduced in lungs of patients with moderate and severe COPD [28], in macrophages gained from BALF of COPD patients when stimulated with IFN-γ [29], and in the skel- ...
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Synthesis, activity, and docking study of phenylthiazole acids as potential agonists of PPARγ
... of PPAR γ is conjugated to fluorescein and is used as the displacement ...of PPAR γ will displace the fluorescent probe, lead- ing to a decrease in ...The PPAR γ Ligand Screening Assay Kit is a ...
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