preclinical model
Validation of a preclinical model for assessment of drug efficacy in melanoma
... xenograft model-specific ...a preclinical model of sarcoma [30], and in a xenograft model of breast cancer in which most of the mutations detected in the primary tumor-derived xenograft were ...
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Spreading depression as a preclinical model of migraine
... clinically, preclinical methods used to study mechanisms of migraine model component features thought to be critical for the pathological generation of a migraine ...
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The application of selective reaction monitoring confirms dysregulation of glycolysis in a preclinical model of schizophrenia
... animal model and control, with Pgam trending toward ...multivariate model suggests that they interact as components of the same pathway in distinguishing the PCP and control ...
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Isolation of circulating tumor cells in a preclinical model of osteosarcoma: Effect of chemotherapy
... pre-clinical model of ...murine model based on patient-derived sarcoma xenografts or murine-tumor allograft surgically implanted into hindlimbs, subsequently amputated followed by an observational period of ...
9
The timing of surgery after neoadjuvant radiotherapy influences tumor dissemination in a preclinical model
... A tumor is composed of cancer cells, non-cancer cells (inflammatory, endothelial and fibroblastic cells) and extracellular matrix [8], which all together elaborate a specific tumor microenvironment that influences the ...
13
Ontogeny and reversal of brain circuit abnormalities in a preclinical model of PCOS
... these preclinical findings, women with PCOS have elevated cerebrospinal fluid levels of GABA, (28) and GABA agonists used in the treatment of epilepsy can result in the onset of PCOS features ...
16
Siponimod therapy implicates Th17 cells in a preclinical model of subpial cortical injury
... a model whereby rats are immunized with myelin (MOG) and supplemented with injections of proinflammatory cytokines ...our model, we chose to examine anti-MOG antibody responses because anti-MOG antibodies ...
19
Preconditioned mesenchymal stem cells treat myasthenia gravis in a humanized preclinical model
... In the current study, we showed that cMSCs were far more efficient than rMSCs. To date, more than 100 clinical trials have already tested MSCs in immune-mediated diseases, and most (if not all) therapies use resting ...
18
Neuroglia in the autistic brain: evidence from a preclinical model
... Increasing appreciation of the multifaceted physiological roles of glia in the developing and mature CNS suggests that abnormalities in glial functions contribute to neuro- pathology. Several preclinical models of ...
17
Patient-derived xenografts: a relevant preclinical model for drug development
... select effective therapeutic strategies for second-line treatment. On this basis, Misale et al. [27] started patients with colorectal cancer on treatment with anti-EGFR inhib- itors as single agents after initial ...
8
Prevention of DNA damage and anticarcinogenic activity of Activia in a preclinical model.
... Comet / micronucleus / aberrant crypt foci observed in the DMH treatment minus the number of cells with Comet / micronucleus / crypt foci aberrant observed in associated groups, divided[r] ...
12
Lithium chloride corrects weakness and myopathology in a preclinical model of LGMD1D
... state in muscle. We used skeletal muscle lysate from 3-month-old LGMD1D model mice that express a V5- tagged DNAJB6b-F93L transgene and control mice that express a DNAJB6b-WT transgene. 8 Of interest, we found a ...
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“De-addictives: Evaluation Methods and its Choice of Remedies from Various System of Medicines’’ – an Update” by Kalashanti R Pyngrope, Anbu J, Radhika M N, Komala M, India.
... Major advances in understanding of neurobiological effect of addictive substances and their short- and long-term consequences in the brain can be provided by using a refined preclinical model such as CPP, ...
8
Multimodal imaging guides surgical management in a preclinical spinal implant infection model
... Spine implant infections portend disastrous outcomes, as diagnosis is challenging and surgical eradication is at odds with mechanical spinal stability. Current imaging modalities can detect anatomical alterations and ...
14
Therapeutic potential of autophagy-enhancing agents in Parkinson’s disease
... In preclinical model systems of PD, the increase of autophagic degradation activity (autophagic flux) by rapamycin and lithium, po- tent autophagy enhancers routinely used in a laboratory setting, resulted ...
18
Preclinical Evaluations To Identify Optimal Linezolid Regimens for Tuberculosis Therapy
... In order for linezolid to fulfill this promise, it is important that an optimized dose and dosing interval be chosen for therapy. The most appropriate dosage regimen will have a major impact on the burden of M. ...
8
Comparison of multi-state Markov models for cancer progression with different procedures for parameters estimation. An application to breast cancer
... used an uninformative flat prior Gamma(0.001, 0.001) for the transition rates. The Gamma distribution is a distribution that is continuous, flexible, and constrained between [0,+∞), and is often used to model ...
10
Neurostimulation of the Cholinergic Antiinflammatory Pathway in Rheumatoid Arthritis and Inflammatory Bowel Disease
... Inflammatory bowel disease (IBD) and rheumatoid arthritis (RA) cause significant morbidity and mortality. Despite significant therapeutic advances, the medical need for patients with these disorders remains high. An ...
10
Targeting SOD1 reduces experimental non–small cell lung cancer
... increased superoxide, which diminished enzyme activity of the antioxidant glutathione peroxidase, leading to an increase in intracellular hydrogen peroxide (H 2 O 2 ) levels. We found that ATN-224–induced cell death was ...
13
Comorbidity and age in the modelling of stroke: are we still failing to consider the characteristics of stroke patients?
... animals) need to be purchased from specialised suppliers, or maintained for long periods (eg, on a particular diet) to induce a relevant phenotype. The latter point, there- fore, significantly increases the time it takes ...
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