Preclinical Studies
Optimized creation of glioblastoma patient derived xenografts for use in preclinical studies
... further studies, for development of novel therapeutics as well as response prediction attempts for individualized therapy ...previous studies but also from clinical experience [30, ...future ...
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Thromboelastography as an instrument of preclinical studies of the potential drug
... To characterize the disorders in the coagulation cascade more accurately, a multiparameter panel has been proposed that assesses the internal, external, and general pathways of coagulation in preclinical GLP (Good ...
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Preclinical studies of ranibizumab for safe use in ophthalmology clinic
... 13 male albino rabbits from New Zealand (genus Oryctolagus, species cunículus, weighing between 1.800 and 2.900 g, and ca. 6 months old) were used in the in vivo trials. This study was duly approved by the Ethics ...
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MHC-identical and transgenic cynomolgus macaques for preclinical studies
... a preclinical model of the induced pluripotent stem cell (iPSC) stock project, we established iPSCs from various types of MHC homozygous macaques, which were transplanted into compatible MHC heterozygous macaques, ...
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PRECLINICAL STUDIES OF THREE DIURETIC PLANTS OF TRADITIONAL USE IN CUBA
... Although the herbal drugs have been used during centuries, alone a small quantity of plants has been investigated through scientific methods that validate its use for that reason the objective of this work is the ...
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Main trends of immune effects triggered by nanomedicines in preclinical studies
... Given the increasing number of nanotechnology-based products in development stage, and the risk of interspecies variations limiting utility of animal studies, cost- and time- effective, humanized in vitro ...
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Preclinical studies of 166Ho-chitosan for treatment of hepatocellular carcinoma
... Injection of 166 Ho-chitosan to rabbit’s liver was performed via two different methods and the leakage of the injected activity from the injection site in the rabbit or[r] ...
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Confirmation of preclinical studies data on tioureidoiminomethylpyridinium perchlorate (perchlozon) in clinic
... clinical studies were performed in accordance with standards of GLP and GCP with utilization of laboratories of experimental medicine at Central Research Institute "Institute of Toxicology“, Irkutsk (2006) and ...
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Management and potentialities of primary cancer cultures in preclinical and translational studies
... Up to now, in vitro and in vivo cancer research has largely depended on the use of immortalized cell lines, which are usually cultured on monolayer supports for in vitro assays or xenografted onto immunocompromised ...
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From probiotics to therapeutics: another step forward?
... Preclinical studies with probiotics continue to unravel mechanisms of cyto- protection and suggest that approaches utilizing microbial products as ther- apeutics in acute and chronic gastrointestinal ...
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Role of bevacizumab therapy in the management of glioblastoma
... from preclinical studies that VEGF is impor- tant for growth of endothelial cells and regulation of tumor angiogenesis; treatment with bevacizumab in vascular tumors like malignant gliomas was anticipated ...
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Integrin Targeting for Tumor Optical Imaging
... vivo studies have revealed some promising integrin-targeting optical agents which have further enhanced our understanding of integrin expression and targeting in cancer biology as well as re- lated anticancer drug ...
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VITAMIN D AS A PROMISING ANTICANCER AGENTP. Shabana*, K. Saipriya, Abbaraju Lakshmi Harini, Pusuluri Dharani Lakshmi Sai, Konkipudi Venkata Sivaiah, Brahmaiah BonthagaralaDOWNLOAD/VIEW
... and preclinical studies support a role of vitamin D compounds in cancer prevention and treatment in colorectal, breast, prostate, ovarian, bladder, lung, skin cancers and leukemia ...
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Emerging Insights for Translational Pharmacokinetic and Pharmacokinetic-Pharmacodynamic Studies: Towards Prediction of Nose-to-Brain Transport in Humans
... administration, preclinical studies to date have typically used the area under the curve (AUC) in brain tissue or cerebrospinal fl uid (CSF) compared to plasma following intranasal and intravenous ...
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Profile of asfotase alfa in the treatment of hypophosphatasia: design, development, and place in therapy
... design, preclinical studies in the HPP mouse model, and outcomes from clinical trials and case report publications to date, with special attention given to response to therapy of skeletal manifestations, ...
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Recent molecular discoveries in angiogenesis and antiangiogenic therapies in cancer
... certain preclinical studies show enhanced metastasis in tumor-bearing mice treated with VEGF-blocking drugs, such as sunitinib (79, 84, 99, ...other preclinical studies did not detect ...
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Should development of Alzheimer’s disease-specific intravenous immunoglobulin be considered?
... III studies with intravenous immunoglobulin (IVIG) in patients with Alzheimer ’ s disease (AD) did not find evidence for the slowing of AD progression compared to placebo-treated patients, in contrast to ...
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Stimuli-responsive polymeric micelles for drug delivery and cancer therapy
... of preclinical studies on multifunctional PMs have been published, which showed that PMs-based drug delivery systems are promising to be an effective nanomedicine platform for drug delivery and cancer ...
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Methods and efficacy of extracellular vesicles derived from mesenchymal stromal cells in animal models of disease: a preclinical systematic review protocol
... summarize preclinical studies investigating the therapeutic efficacy of both small and large extracellular vesicles derived by mesenchymal stromal ...of preclinical studies published to ...
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... Multiple preclinical studies have validated the effects of radioimmunotherapy.²⁶⁻²⁸ A combination of radiation and the injection of dendritic cells in a mice model showed a significant increase in tumor ...
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