precore protein
The hepatitis B virus (HBV) precore protein inhibits HBV replication in transgenic mice.
... that precore gene products do not interfere with viral transcription in the nucleus and/or viral RNA stability in the ...The precore RNA could theoretically compete with the less abun- dant core RNA at the ...
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Hepatitis B virus p25 precore protein accumulates in Xenopus oocytes as an untranslocated phosphoprotein with an uncleaved signal peptide.
... 37-45 0022-538X/92/010037-09$02.00/0 Copyright © 1992, American Society for Microbiology Hepatitis B Virus p25 Precore Protein Accumulates in Xenopus Oocytes as an Untranslocated Phospho[r] ...
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Posttranscriptional regulation of hepatitis B virus replication by the precore protein.
... core protein, which subsequently becomes a structural component of the viral ...p25 precore protein that is targeted by a signal peptide to a cell secretory pathway where N-terminal processing will ...
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Hepatitis B Precore Protein: Pathogenic Potential and Therapeutic Promise
... Immunoglobulins are centrally important for the modula- tion of the immune response, and immunoglobulin therapy is already an accepted and clinically proven therapy in HBV treatment, with HBsAg targeted by HBIg therapy ...
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Biosynthesis of the secretory core protein of duck hepatitis B virus: intracellular transport, proteolytic processing, and membrane expression of the precore protein.
... 7 0022-538X/91/073489-07$02.00/0 Copyright C 1991, American Society for Microbiology Biosynthesis of the Secretory Core Protein of Duck Hepatitis B Virus: Intracellular Transport, Proteo[r] ...
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Transport of hepatitis B virus precore protein into the nucleus after cleavage of its signal peptide.
... Since COS-7 cells transfected with pECE-PC did not synthesize detectable amounts of P21c, we cotransfected plasmids expressing core and precore proteins pECE-C and pECE-PC, respectively [r] ...
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The quaternary structure, antigenicity, and aggregational behavior of the secretory core protein of human hepatitis B virus are determined by its signal sequence.
... When a truncated hepatitis B virus precore protein, lacking the basic C-terminal domain which is cleaved from the wild-type protein during its conversion into HBe, was expressed in human[r] ...
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Immune Tolerance Split between Hepatitis B Virus Precore and Core Proteins
... 21-kDa protein that self-assembles into particles that encapsidate the viral genome and polymerase and is essential to the function and maturation of the ...the precore or hepatitis B e antigen (HBeAg). The ...
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Enrichment of a Precore-Minus Mutant of Duck Hepatitis B Virus in Experimental Mixed Infections
... the precore-minus ...our precore mutant is not ...the precore protein is not incorpo- rated into virus ...and precore proteins of HBV are generally considered to be antigenically ...
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Impaired Quality of the Hepatitis B Virus (HBV)-Specific T-Cell Response in Human Immunodeficiency Virus Type 1-HBV Coinfection
... Chronic HBV infection is generally associated with a narrow HBV-specific response, with the dominant response often be- ing to precore protein (24, 48, 66). We were therefore sur- prised to find such a ...
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Evidence for a base-paired region of hepatitis B virus pregenome encapsidation signal which influences the patterns of precore mutations abolishing HBe protein expression.
... 5651-5655 0022-538X/93/095651-05$02.00/0 Copyright © 1993, American Society for Microbiology Evidence for a Base-Paired Region of Hepatitis B Virus Pregenome Encapsidation Signal Which I[r] ...
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Hepatitis B virus genotypes and precore and core mutants in UAE patients
... Conclusion/Significance: HBV infection is a major health problem in the UAE, and while genotypes B and C are the most prevalent HBV genotypes in the Asian population, our study reveals that genotype D is the predominant ...
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Precore-mediated inhibition of hepatitis B virus progeny DNA synthesis.
... i Cotransfection of the high-replicator DNA4 pd4 with a monomer construct of the low-replicator DNA pm2 reduced the level of progeny DNA; ii complementation of a defective DNA2 incapable[r] ...
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Hepatitis B Virus Genotypes and Precore and Core Mutants in Brazilian Patients
... the precore region leading to initiation failure or premature ...in precore promoter region before exacerbation, but in a later sample this deletion was no longer found ...
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Hepatocyte Nuclear Factor 3β Inhibits Hepatitis B Virus Replication In Vivo
... core protein in the liver of the rat HNF3-express- ing HBV transgenic mice was dramatically reduced compared with the control rat HNF3(⫺) HBV transgenic mice ...than precore RNA synthesis ...
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Clinical and Serological Variation between Patients Infected with Different Hepatitis B Virus Genotypes
... and precore sequences were determined for the isolates from 101 of these ...and precore regions were significantly correlated with elevated ALT levels in the ...
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Hepatitis B virus precore mutation and fulminant hepatitis in the United States A polymerase chain reaction based assay for the detection of specific mutation
... with precore mutation(s) resulting in the absence of HBeAg production have been associated with the occurrence of fulminant hepatitis in Japan, Israel, and southern Europe, where the prevalence of this HBV strain ...
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Phylogenetic, Virological, and Clinical Characteristics of Genotype C Hepatitis B Virus with TCC at Codon 15 of the Precore Region
... Clinical features. Patients infected with HBV strains with TCC at nucleotides 1856 to 1858 had a higher prevalence of liver cirrhosis (18%) compared to the prevalence among those infected with HBV strains bearing CCC ...
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Prevention and treatment of recurrent Hepatitis B after liver transplantation: the current role of nucleoside and nucleotide analogues
... : Lamivudine therapy in patients undergoing liver transplantation for Hepatitis B virus precore mutant-associated infection: High resistance rates in treatment of recurrence but univers[r] ...
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Mutations in the Basal Core Promoter and Precore/Core Regions of Hepatitis B Virus in Patients Co-Infected With Human Immunodeficiency Virus
... homosexual men followed by intravenous drug users, especially in Iran (8, 9). The rate of HBV virion production (up to 10 11 /day) is higher than HIV and approximately 10 times higher than other DNA viruses. The HBV ...
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