precursor protein
Heteromers of amyloid precursor protein in cerebrospinal fluid
... CSF: Cerebrospinal fluid; sAPP: Soluble amyloid precursor protein; sAPP α : sAPP fragment generated after α -secretase cleavage; sAPP β : sAPP fragment generated after β -secretase cleav[r] ...
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The amyloid precursor protein: beyond amyloid
... amyloid precursor protein (APP) takes a central position in Alzheimer's disease (AD) pathogenesis: APP processing generates the β-amyloid (Aβ) peptides, which are deposited as the amyloid plaques in brains ...
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Biology and pathophysiology of the amyloid precursor protein
... Alzheimer’s disease (AD) is the most common cause of dementia and neurodegenerative disorder in the elderly. It is characterized by two pathological hallmarks: senile plaques and neurofibrillary tangles, as well as loss ...
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Amyloid precursor protein and amyloid precursor-like protein 2 in cancer
... Amyloid precursor protein (APP) is an evolutionarily conserved protein with two homologues in mammals: amyloid precursor-like protein 1 (APLP1) and amyloid precursor-like ...
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Studies on the amyloid precursor protein: Implications for Alzheimer's disease
... Indirect evidence supporting a role for B/A4 in the aetiology of AD came following the discovery that the gene for the B/A4 precursor protein APP, is localised to chromosome 21 (Kang et a i , 1987) and is ...
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Cytotoxic Aggregation and Amyloid Formation by the Myostatin Precursor Protein
... myostatin precursor protein (MstnPP) with Ab aggregates and increased levels of both MstnPP and the processed myostatin growth factor dimer ...Ab precursor protein showed an increase in MstnPP ...
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Role of Phosphoinositides in the biology of the amyloid precursor protein
... amyloid precursor protein-induced proliferation of neural stem/progenitor ...Beta-amyloid precursor protein: Function in stem cell development and Alzheimer’s disease ...
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Molecular consequences of amyloid precursor protein and presenilin mutations causing autosomal-dominant Alzheimer's disease
... Alzheimer’s disease (AD) is the most common age- related neurodegenerative disorder, currently aff ecting 20 to 30 million individuals worldwide [1]. Th e cardinal symptom of the disease is progressive memory loss due to ...
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Modulation of β-amyloid precursor protein trafficking and processing by the low density lipoprotein receptor family
... β-amyloid precursor protein; APLP1, amyloid precursor like proteins-1; APLP2, amy- loid precursor like proteins-2; sAPP, soluble APP frag- ment; sAPP β , soluble β -cleaved APP fragment; BACE, ...
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Role of Phosphoinositides in the biology of the amyloid precursor protein
... having the weakest affinity for A β (Strittmatter et al., 1993; Yang et al., 1997; Tokuda et al., 2000). Cells have been reported to internalise apoE-bound A β via an LRP1-dependent mechanism, which has been suggested to ...
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Processing of Alzheimer's amyloid precursor protein in cultured cells
... neuronal precursor cells are ...neurofilament protein, and do not express vimentin filaments (found in some neurones, glial and other cells) or glial ...
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Nuclear localization of foamy virus Gag precursor protein.
... SCHLIEPHAKE AND AXEL RETHWILM* Institut fair Virologie und Immunbiologie, Wwrzburg, Germany Received 1 January 1994/Accepted 27 April 1994 cence that is observed when human immunodeficie[r] ...
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Amyloid precursor protein modulates β-catenin degradation
... Several lines of evidence suggest that APP influences β-cat- enin regulation. APP binds to APP-BP1 which activates the small ubiquitin-like protein Nedd8 [7,8]. Activated Nedd8 modifies Cullins which then becomes ...
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Inhibition of Protein Phosphatase 1 Stimulates Secretion of Alzheimer Amyloid Precursor Protein
... Okadaic acid, a protein phosphatase inhibitor, has been shown to stimulate secretion of APPs, but the identity of the phosphatase involved has not been investigated.. Materials and Metho[r] ...
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The Functions of the Amyloid Precursor Protein Gene and Its Derivative Peptides: III Pharmacological Studies
... and protein dam- age [44] and oxidative stress in a cell-free system ...metal protein bind- ing substance that inhibits zinc and copper ions, has been shown to slow cognitive decline in a small sample of AD ...
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Precursor Protein for Newcastle Disease Virus
... Of the three major virion polypeptide molecular weight classes, I 78,400 daltons, II 53,500 daltons, and III 37,600 daltons, only II, having the same electrophoretic mobility as nucleoca[r] ...
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Proteomics of protein post translational modifications implicated in neurodegeneration
... disease-specific protein aggregation ...granule protein TDP-43 is also hyperphosphorylated, cleaved, ubiquitinated, and/or oxidized, all preferentially in the insoluble fraction of neurodegenerative disease ...
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The uptake of proteins by the chloroplast and their subsequent routing to the thylakoid
... By blocking the recognition of the SPP cleavage site of the precursor of the 23kDa protein pre-23K of the OEC, it was shown that the import of precursor protein into isolated chloroplast[r] ...
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The role of APP in Alzheimer’s disease
... Alzheimer’s disease (AD) is one of the most sig- nificant neurodegenerative disorders in terms of both severity and cost. Despite being defined over a century ago, there is currently no cure to this disease that affects ...
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Recombinant feline herpesviruses expressing feline leukemia virus envelope and gag proteins.
... To determine whether the gag-protease precursor protein was expressed by FHV-116 and whether this protein was able to effect proteolytic processing of the FeLV gag precursor 6, 38, 47, w[r] ...
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