Preexisting immunity
Optimized Adenovirus-Antibody Complexes Stimulate Strong Cellular and Humoral Immune Responses against an Encoded Antigen in Naïve Mice and Those with Preexisting Immunity
... To our knowledge this is the first report describing the im- munological profile of a defined series of antibody:adenovirus combinations in both naïve mice and those with preexisting immunity. Although ...
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Unraveling the role of preexisting immunity in prostate cancer patients vaccinated with a HER-2/neu hybrid peptide
... tumor-specific preexisting immunity, we also analyzed our vaccinated patients for preexisting immunity to the vaccine by AE36-specific IFNγ-based ELISPOT assay and by ...whether ...
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Symptomatic Congenital Cytomegalovirus Infection in Infants Born to Mothers With Preexisting Immunity to Cytomegalovirus
... Additional factors that may affect the transmission of CMV with subsequent disseminated fetal infection in women with preexisting immunity include viral strain variation and strain-dependent immune re- ...
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Effect of Preexisting Immunity to Adenovirus Human Serotype 5 Antigens on the Immune Responses of Nonhuman Primates to Vaccine Regimens Based on Human- or Chimpanzee-Derived Adenovirus Vectors
... NHPs, preexisting immunity to an- tigens of Ad results in a pronounced enrichment of T cells in the liver, induced by vaccination with homologous or heterol- ogous Ad ...Third, preexisting ...
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Replacing adenoviral vector HVR1 with a malaria B cell epitope improves immunogenicity and circumvents preexisting immunity to adenovirus in mice
... Although adenovirus (Ad) has been regarded as an excellent vaccine vector, there are 2 major drawbacks to using this platform: (a) Ad-based vaccines induce a relatively weak humoral response against encoded transgenes, ...
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Effect of Preexisting Immunity on an Adenovirus Vaccine Vector: In Vitro Neutralization Assays Fail To Predict Inhibition by Antiviral Antibody In Vivo
... We developed vectors derived from chimpanzee Ads to which humans lack preexisting immunity. When tested in a rodent model, one such vector, AdC68, induces potent trans- gene product-specific CD8 ⫹ T-cell ...
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Influence of Promoter, Gene Copy Number, and Preexisting Immunity on Humoral and Cellular Responses to a Vectored Antigen Delivered by a Salmonella enterica Vaccine
... STM-1 is an S. enterica serovar Typhimurium mutant devel- oped by RMIT and harbors a mutation in the aroA gene region that renders it attenuated (M. Saxena, P. Smooker, and P. Coloe, submitted for publication). It is a ...
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Attenuated Modified Vaccinia Virus Ankara Can Be Used as an Immunizing Agent under Conditions of Preexisting Immunity to the Vector
... with preexisting immunity against the vector, MVA or WR. The immune response induced against a recombinant antigen expressed after a booster with MVA was then compared with that in animals primed with the ...
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Effect of Preexisting Immunity on Oncolytic Adenovirus Vector INGN 007 Antitumor Efficacy in Immunocompetent and Immunosuppressed Syrian Hamsters
... antivector immunity (NAb, cell-mediated, adaptive, and innate immu- nity) can quickly reach a level where it can impede vector antitumor efficacy, and the level of preexisting immunity does not make ...
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Preexisting Immunity to Poliovirus Does Not Impair the Efficacy of Recombinant Poliovirus Vaccine Vectors
... of preexisting immunity to vaccinia virus is more severe in animals with higher antibody titers to the virus (3, ...since immunity to poliovirus is thought to be mostly antibody mediated, but the ...
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Preexisting Immunity, Not Frailty Phenotype, Predicts Influenza Postvaccination Titers among Older Veterans
... is preexisting immunity to influenza. In fact, preexisting immunity to influenza has been proposed as a greater correlate of immunity to influenza than age among elderly persons ...
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Preexisting Immunity to Adenovirus in Rhesus Monkeys Fails To Prevent Vector-Induced Toxicity
... that preexisting immunity did not substantially alter the activation of innate immunity, which previously was ascribed to the targeting of ...
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Dual muscle-liver transduction imposes immune tolerance for muscle transgene engraftment despite preexisting immunity
... system. Preexisting anticapsid antibody responses observed for adenoassociated virus (AAV) sero- types, prevalent mostly in humans (5, 6), can impair treatment effectiveness (7), which advocates for the use of ...
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Quantifying Adenovirus Neutralizing Antibodies by Luciferase Transgene Detection: Addressing Preexisting Immunity to Vaccine and Gene Therapy Vectors
... To compare replication inhibition with transgene expression, a panel of human serum samples, negative FBS, and a serotype-specific horse serum pool as reference serum were tested for ant[r] ...
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Respiratory Syncytial Virus Infects and Abortively Replicates in the Lungs in Spite of Preexisting Immunity
... Respiratory syncytial virus (RSV) is a major cause of bronchiolitis and viral pneumonia in young children and a serious health risk in immunocompromised individuals and the elderly. Immunity to RSV is not ...
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A Complex Adenovirus-Vectored Vaccine against Rift Valley Fever Virus Protects Mice against Lethal Infection in the Presence of Preexisting Vector Immunity
... Ad5 preexisting immunity may not be as critical as was initially thought and that using an alternative serotype to bypass preexisting immunity may not be ...between preexisting Ad5 ...
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Regulatable Gutless Adenovirus Vectors Sustain Inducible Transgene Expression in the Brain in the Presence of an Immune Response against Adenoviruses
... Preexisting immunity against gene therapy vectors, as could be present in human patients undergoing gene therapy trials, can have damaging effects on the persistence of therapeutic transgene expression ...
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Intramuscular Delivery of Adenovirus Serotype 5 Vector Expressing Humanized Protective Antigen Induces Rapid Protection against Anthrax That May Bypass Intranasally Originated Preexisting Adenovirus Immunity
... Viral vectors can be used to express proteins from pathogens for immunization against infectious diseases (11). Due to their safety, ease of manipulation, and capacity to elicit potent innate and adaptive immune ...
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Herpes Simplex Virus Vectors Elicit Durable Immune Responses in the Presence of Preexisting Host Immunity
... that preexisting immunity can di- minish the ability of an HSV gene therapy vector to transduce a tumor in mice following intravenous delivery (28) but not after direct intratumoral injection ...
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Airway Delivery of an Adenovirus-Based Ebola Virus Vaccine Bypasses Existing Immunity to Homologous Adenovirus in Nonhuman Primates
... 5 preexisting immunity, result- ing in protection against species-adapted Ebola virus ...and preexisting immunity before and after a lethal Ebola virus (Zaïre strain Kikwit 95) ...of ...
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