Pregnane X receptor
Roles of rifampicin in drug-drug interactions: underlying molecular mechanisms involving the nuclear pregnane X receptor
... Nuclear pregnane X receptor (PXR) and constitutive androstane receptor (CAR) have now been discovered and their roles in rifampicin-mediated drug-drug ...
11
Glucocorticoid Regulation of the Pregnane X Receptor is a Key Determinant in the Magnitude of CYP3A Induction by Xenobiotics
... activate pregnane X receptor (PXR), and enhanced 3A4 activity has been implicated in adverse drug ...glucocorticoid receptor (GR)- mediated ...
87
Identification of Novel Transcription Start Sites and Distinct Proximal Promoter Regions for Pregnane X Receptor (PXR) Isoforms PXR 1 and PXR 2
... RT-PCR to map 5’ regions of PXR 1 and PXR 2. We began our investigation of the 5’ regions of PXR 1 and PXR 2 with analysis of sequences available from the NCBI database. However, most sequences shared little to no ...
115
Characterizing the pregnane X receptor's interactions and biophysical properties
... human pregnane X receptor PXR plays a important role in controlling the expression of genes central to drug and endobiotic metabolism, including those encoding cytochrome P450s (CYPs), ...
159
Tanshinone IIA ameliorates dextran sulfate sodium-induced inflammatory bowel disease via the pregnane X receptor
... Abstract: Tanshinone IIA (Tan IIA) (C 19 H 18 O 3 ) is one of the major active lipophilic components in a conventional Chinese medicine called danshen, and it has long been used in the People’s Republic of China and ...
20
Pregnane X receptor activation induces FGF19 dependent tumor aggressiveness in humans and mice
... nuclear receptor pregnane X receptor (PXR) is activated by a range of xenochemicals, including chemo- therapeutic drugs, and has been suggested to play a role in the development of tumor cell ...
14
Pregnane X-receptor promotes stem cell-mediated colon cancer relapse
... Colorectal cancer lethality usually results from post-treatment relapse in the majority of stage II-IV patients, due to the enhanced resistance of Cancer Stem Cells (CSCs). Here, we show that the nuclear receptor ...
16
Microcantilever based Nanomechanical Studies of the Orphan Nuclear Receptor Pregnane X Receptor Ligand Interactions
... Human pregnane X receptor (PXR) is of vital importance in pharmaceutical and exogenous compound metabolism within the ...estrogen receptor (ER-) directly compares the nanomechanical ...
10
Protein arginine methyltransferase 1 may be involved in pregnane x receptor-activated overexpression of multidrug resistance 1 gene during acquired multidrug resistant
... Pregnane x receptor (PXR) is an orphan nuclear receptor that have been proven to play an essential role in the development of MDR [5–7]. In vitro, tumor cells can be induced to acquire MDR by ...
13
Possible involvement of pregnane X receptor–enhanced CYP24 expression in drug induced osteomalacia
... and carbamazepine (13–17). Indeed, long-term antiepileptic drug therapy, such as phenobarbital or carbamazepine, is a known risk factor for bone loss and fractures (13). In addition, prolonged ther- apy with rifampicin ...
11
Endosulfan-alpha Induces CYP2B6 and CYP3A4 via the Pregnane X Receptor
... human pregnane X receptor (PXR) and induce the expression levels of cytochrome P450 (CYP or P450) enzymes, thereby increasing metabolic rates for steroid ...
98
Tissue-specific regulation of pregnane X receptor in cancer development and therapy
... Phase III transporters include P-glycoprotein (P-gp; also known as multidrug resistance protein-1, or MDR1), multidrug resistance-associated proteins, and organic transporting polypeptides [4]. Nevertheless, induction of ...
8
<p>miR-3609 Decelerates the Clearance of Sorafenib in Hepatocellular Carcinoma Cells by Targeting EPAS-1 and Reducing the Activation of the Pregnane X Receptor Pathway</p>
... The pregnane X receptor (PXR) not only plays an important role in cellular metabolism processes but also induces the resistance of hepatocellular carcinoma (HCC) cells to molecularly targeted drugs ...
15
A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response
... The pregnane X receptor (PXR) and the constitutive androstane receptor (CAR) are closely related orphan nuclear hormone receptors that play a critical role as xenobiotic sensors in ...
13
Pregnane X receptor activation potentiates ritonavir hepatotoxicity
... human pregnane X receptor by rilpivirine and etravirine: comparison with first generation non-nucleoside reverse transcriptase ...nuclear receptor PXR is activated by compounds that regulate ...
7
Gancao (Glycyrrhizae Radix) provides the main contribution to Shaoyao Gancao decoction on enhancements of CYP3A4 and MDR1 expression via pregnane X receptor pathway in vitro
... Cytochrome P450 (CYP450) occupies an important role in the metabolism and detoxification process of drug and other endo-or xeno-biotics. The largest fraction of the CYP450 CYP3A4, representing 40% of the total hepatic ...
12
The flavokawains: uprising medicinal chalcones
... Apart from HSC-3 cell line, flavokawain B can also be cyto- toxic towards synovial sarcoma cell lines [33]. A study by Sakai et al. in 2011 [33], used two synovial sarcoma lines, SYO-1 and HS-SY-II to test for the ...
7
Assessing the endocrine disrupting potentials and genotoxicity in environmental samples from Taiwanese rivers
... estrogen receptor (ER) represent an im- portant category of EDCs owing to their possible interference with reproductive ...hormone receptor (TR), glucocorticoid receptor (GR), mineralocorticoid ...
9
Estrogens and male reproduction
... At the same time, the development of a line of transgenic male mice lacking estrogen receptor (x, estrogen receptor I~ or aromatase gene provided further evidence [r] ...
5
The effect of genistein on lipid levels and LDLR, LXRα and ABCG1 expression in postmenopausal women with hyperlipidemia
... liver X receptor (LXR), which is a major transcription factor important in cholesterol metabolism that is activated in response to cellular cholesterol levels 5 ...
8