Presenilin-1 (PS1)
Dynamic presenilin 1 and synaptotagmin 1 interaction modulates exocytosis and amyloid β production
... β-secretase 1 (BACE1) and presenilin 1 (PS1)/γ-secretase, are abundantly present at the synaptic terminals [9–12], enabling local production of ...the PS1/γ-secretase con- formational ...
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Increase in Presenilin 1 (PS1) levels in senescence accelerated mice (SAMP8) may indirectly impair memory by affecting amyloid precursor protein (APP) processing
... of presenilin-1 (PS1), nicastrin, APH-1 and ...As PS1 has been shown to play a critical role in facilitating γ -secretase activity, and mutations in this protein are associated with ...
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Familial Alzheimer’s disease–associated presenilin 1 alters cerebellar activity and calcium homeostasis
... encoding presenilin-1 (PS1) are found in approximately 80% of cases of FAD, with some of these patients presenting cerebellar damage with amyloid plaques and ataxia with unclear ...the ...
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Interrelationship between Changes in the Amyloid β 42/40 Ratio and Presenilin 1 Conformation
... component presenilin 1 ...and PS1 conformation in primary ...the PS1 subdomain architecture toward the pathogenic “closed” ...and PS1 conformation within a neuron, with Aβ40 showing ...
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Presenilin 1 in migration and morphogenesis in the central nervous system
... Presenilin 1 and 2 (Psen1 and Psen2) are polytopic membrane proteins that are mutated in the majority of pedigrees with early-onset familial Alzheimer’s disease (Price and Sisodia, ...
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Binding of longer Aβ to transmembrane domain 1 of presenilin 1 impacts on Aβ42 generation
... TMD1 and the neighboring TMDs [30]. However, we have previously suggested a piston-like vertical move- ment of TMD1 by SCAM [34], supporting our view that dynamic conformational changes would take place dur- ing the ...
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Structural biology of presenilin 1 complexes
... of presenilin complex: recent bi-lobed models Early in 2014, a considerable advance in the structural modeling of the presenilin complex was achieved when negative stain 3D electron microscopy data were ...
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CSF Presenilin-1 complexes are increased in Alzheimer’s disease
... in PS1 complex stability as resolved by sucrose density gra- ...of PS1 correlating with an increased proportion of stable complexes in post-mortem CSF, results in lumbar CSF suggest that the early and more ...
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Changes in γ-secretase activity and specificity caused by the introduction of consensus aspartyl protease active motif in Presenilin 1
... proteins, presenilin (PS1 or PS2), nicastrin, aph1 and pen2, are needed to form an active γ-secretase complex ...in PS1 and PS2 but not in the other γ-secretase components are a common cause of the ...
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Cerebrospinal fluid Presenilin-1 increases at asymptomatic stage in genetically determined Alzheimer’s disease
... heteromeric PS1 com- plexes in human CSF (CSF-PS1) and serum, and that increases in the proportion of stable CSF-PS1 complexes served to discriminate sAD from non-disease controls ...[12]. PS1 ...
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APP-BP1 inhibits Aβ42 levels by interacting with Presenilin-1
... In neurons infected with APP695 with or without the APP-BP1 siRNA virus, APP-CTF levels were analyzed in 16% Tris-Tricine gels using the antibody 369. A represent- ative blot is shown in Fig. 3C. Based on a two-tail ...
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Original Article Ultrastructural studies in APP/PS1 mice expressing human ApoE isoforms: implications for Alzheimer’s disease
... Abstract: Alzheimer’s disease is characterized in part by extracellular aggregation of the amyloid-β peptide in the form of diffuse and fibrillar plaques in the brain. Electron microscopy (EM) has made an important ...
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Diets involved in PPAR and PI3K/AKT/PTEN pathway may contribute toneuroprotection in a traumatic brain injury
... of presenilin 1 (PS1) downregulates its cell- surface expression, which leads to an impaired activation of the PI3K/AKT cell survival ...The PS1 also reg- ulates induction of hypoxia-inducible ...
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Cognitive improvement of compound danshen in an Aβ25 35 peptide induced rat model of Alzheimer’s disease
... BACE1. Presenilin-1 is one of the most import- ant cleaving enzymes of γ-secrectases, which mainly mediates the regulated proteolytic events of APP ...down-regulated PS1 mRNA ...decreased PS1 ...
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Evidence that the β-catenin Nuclear Translocation Assay Allows for Measuring Presenilin 1 Dysfunction
... for presenilin (PSEN1), -catenin, glycogen synthase kinase-3 (GSK3 ), and -actin expression levels before (0 min) and after (60 min) LiCl ...using 1/4000 mouse monoclonal anti- ...using 1/4000 ...
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Selective expression of presenilin 1 in neural progenitor cells rescues the cerebral hemorrhages and cortical lamination defects in presenilin 1 null mutant mice
... additional 1 kb containing the β -actin exon 1, intron 1 and 5 ′ untranslated sequence from exon 2, while downstream of exon 2 it contains a translation ‘stop’ cassette sequence (Lakso et ...
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Developmental Expression of Wild-Type and Mutant Presenilin-1 in Hippocampal Neurons from Transgenic Mice: Evidence for Novel Species-Specific Properties of Human Presenilin-1
... The distribution of PS 1 in the transgenic neurons expressing human wtPS I and the M146L mutant was also investigated to determine whether the human proteins localized in a markedly diff[r] ...
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The genetics of Alzheimer's disease
... the Mendelian inheritance pattern; however, EOAD patients have also been reported without any family history (termed “sporadic EOAD”). Three genes are considered the main risk factors for EOAD: amyloid precursor protein ...
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Mutations in presenilin 2 and its implications in Alzheimer’s disease and other dementia-associated disorders
... encoding presenilin 1 (PSEN1), presenilin 2 (PSEN2), and amyloid precursor protein have been identified as the main genetic causes of familial ...
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Autophagy dysfunction upregulates beta-amyloid peptides via enhancing the activity of γ-secretase complex
... In the present study, the glioma cell line SH-SY5Y was treated with autophagy inhibitor (3-MA) and autophagy inducer (STF-62247). Then, the cell harvested to analyze by real-time quantitative PCR and Western blotting. ...
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