pressure overload
Fas receptor signaling inhibits glycogen synthase kinase 3β and induces cardiac hypertrophy following pressure overload
... of pressure overload, GSK3β immunocomplex kinase assays of myocardial homogenates were performed at various time points following aortic ...of pressure overload was lower in lpr mice ...tor, ...
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Effects of pressure overload, left ventricular hypertrophy on beta adrenergic receptors, and responsiveness to catecholamines
... Pressure overload left ventricular (LV) hypertrophy was produced by banding the ascending aorta of puppies and allowing them to grow to ...arterial pressure, heart rate, and LV end-diastolic ...
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Reversal of Systemic Hypertension-Associated Cardiac Remodeling in Chronic Pressure Overload Myocardium by Ciglitazone
... ventricular pressure overload model in mice ...chronic pressure overload, in part, by increasing SOD, eNOS and elastin and decreasing NOX4 (NADPH oxidase subunit), MMP and collagen synthesis ...
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Effects of anesthesia on conventional and speckle tracking echocardiographic parameters in a mouse model of pressure overload
... of pressure overload/aortic stenosis and assessed whether an anesthetic was able to limit the effectiveness of echocardiography in the evaluation of cardiac function ...
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Original Article Exercise preconditioning attenuates pressure overload-induced pathological cardiac hypertrophy
... Pathological cardiac hypertrophy, accompany- ing with hypertension, aortic stenosis and valve defects, is typically associated with myocytes remodeling and fibrotic replacement, cardiac dysfunction, and increases risk of ...
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Alteration of growth responses in established cardiac pressure overload hypertrophy in rats with aortic banding
... established pressure overload left ventricular hypertrophy. Isolated rat hearts with chronic hypertrophy (LVH) were studied 12 wk after ascending aortic banding when systolic function was fully maintained. ...
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Induction of cardiomyocyte proliferation and angiogenesis protects neonatal mice from pressure overload–associated maladaptation
... 45). Pressure overload at the adult stage in mice is also associated with increased abundance of inflammatory cells (mainly macrophages), although controversy still exists as to whether they play an ...
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Excessive cardiac insulin signaling exacerbates systolic dysfunction induced by pressure overload in rodents
... sure overload enhances insulin signaling in the heart, we examined pIrs1 levels immediately after ...that pressure overload markedly increased the pIrs1 level from as early as 1 minute after the ...
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Proapoptotic Rassf1A/Mst1 signaling in cardiac fibroblasts is protective against pressure overload in mice
... TNF-α mediates the effects of Rassf1A in vivo. (A–K) TAC was per- formed to generate pressure overload in vivo for 1 week. (A and C) Whole hearts were removed and homogenized, and TNF-α concentra- tion was ...
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CXCR3 regulates CD4+ T cell cardiotropism in pressure overload–induced cardiac dysfunction
... and CXCL10, they can further release IFNγ and, in turn, induce CXCL9 and CXCL10 production by cardiac myeloid cells and cardiac fibroblasts to induce subsequent waves of T cell recruitment in a cycle that con- tributes ...
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Cardiomyocyte proliferation prevents failure in pressure overload but not volume overload
... hemodynamic overload. We induced pressure overload by transthoracic aortic constriction (TAC) or volume overload by aortocaval shunt in cyclin D2– expressing and WT ...after pressure ...
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Intermittent pressure overload triggers hypertrophy independent cardiac dysfunction and vascular rarefaction
... intermittent pressure overload displayed pathological ...intermittent pressure overload caused diastolic dysfunction, altered b- adrenergic receptor (bAR) function, and vascular rarefaction ...
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Original Article Triggering the succinate receptor GPR91 enhances pressure overload-induced right ventricular hypertrophy
... Although succinate has been intensely studied for more than 60 years in the context of energy production, the recent demonstration that it can induce cellular signaling transduction through GPR91 has raised the ...
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Endothelial Nogo-B regulates sphingolipid biosynthesis to promote pathological cardiac hypertrophy during chronic pressure overload
... The loss of Nogo-A/B protected mice from pressure overload–induced cardiac hypertrophy and dysfunction. Recently, we reported that mice lacking Nogo-A/B are markedly hypotensive (~25 mmHg) compared with WT ...
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Edaravone inhibits pressure overload-induced cardiac fibrosis and dysfunction by reducing expression of angiotensin II AT1 receptor
... Taken together, we demonstrate that treatment with edara- vone inhibits cardiac fibrosis and improves left ventricular function in the setting of 8 weeks of pressure overload in rats after TAC. Mechanisms ...
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Effect of Cyclodextrin Garcinol Complex on Pressure Overload- Induced Cardiotoxicity and Cardiac Hypertrophy by Aortic Stenosis in Rats
... Results: Pressure overload induced by arotic stenosis in rat resulted in significant myocardial hypertrophy and decreased endogenous antioxidants when compared with the control and sham group ...
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Decreased stimulatory guanosine triphosphate binding protein in dogs with pressure overload left ventricular failure
... adrenergic agonist high-affinity binding sites and a decreased adenylate cyclase activity in sarcolemma from failing hearts. Using cholera toxin and [32P]NAD, we labeled the alpha subunit of Gs (Gs alpha) and found a 59% ...
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Accumulation of fetal fibronectin mRNAs during the development of rat cardiac hypertrophy induced by pressure overload
... analyzed. Pressure overload was induced in 25-d-old rats by stenosis of the thoracic ...to pressure overload by reexpressing fetal gene ...
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Energetics of acute pressure overload of the porcine right ventricle In vivo 31P nuclear magnetic resonance
... systolic pressure 31 +/- 1 mm Hg), and with pulmonary artery constriction to produce moderate pressure overload (RV systolic pressure 45 +/- 1 mm Hg), and maximal pressure ...
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The MEKK1 JNK pathway plays a protective role in pressure overload but does not mediate cardiac hypertrophy
... during pressure over- load–induced cardiac ...that pressure overload–induced cardiac hypertrophy occurs even in the absence of upregulation of TNF-α or ...to pressure overload occurred ...
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