Primary CNS Lymphoma
Therapeutic challenges in primary CNS lymphoma
... International Primary CNS Lymphoma Collaborative Group) has been working to defi ne current standards, establish consensus guidelines for the reporting of clinical trials, and develop new research ...
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Prognostic impact of B-cell lymphoma 6 in primary CNS lymphoma.
... with primary CNS lymphoma (PCNSL) homogeneously receiving high-dose methotrexate (HDMTX)-based chemotherapy within the prospective G-PCNSL-SG1 ...B-cell lymphoma 2 (BCL2), BCL6, CD10, and ...
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MR imaging features of intracranial primary CNS lymphoma in immune competent patients
... Abstract We aimed to characterize specific MRI findings seen in immune competent patients with intracranial primary CNS lymphoma (PCNSL) and to determine their value in the management of such ...
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Ibrutinib Unmasks Critical Role of Bruton Tyrosine Kinase in Primary CNS Lymphoma.
... Additional details on genomic analysis and in vitro experiments using PCNSL patient- derived xenograft models and cell line are available "online only". Genomic analysis All RNA and DNA sequencing of human tumor samples ...
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Differentially regulated miRNAs as prognostic biomarkers in the blood of primary CNS lymphoma patients
... Abstract: Despite improved therapeutic regimens, primary CNS lymphoma (PCNSL) remains a therapeu- tic challenge. A prognostic classification of PCNSL patients may represent an important step towards ...
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Advanced MR Imaging Techniques in Pre-Operative Diagnosis of Primary CNS Lymphoma
... N Primary CNS lymphoma may arise from different parts of the brain, with deep hemispheric periventricular white matter being the most common site of ...
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Imaging Changes and Cognitive Outcome in Primary CNS Lymphoma after Enhanced Chemotherapy Delivery
... in primary CNS lymphoma (PCNSL) patients who attained a complete response (CR) after treatment with chemotherapy and osmotic blood-brain barrier disruption ...
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Diagnosis and treatment of primary CNS lymphoma in immunocompetent patients: guidelines from the European Association for Neuro-Oncology
... International Primary CNS Lymphoma Collaborative Group (IPCG) published a consensus opinion to standardize response criteria and outcome measures in immunocompetent patients with ...ocular ...
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The added value of advanced neuro-imaging (MR diffusion, perfusion and proton spectroscopy) in diagnosis of primary CNS lymphoma
... of primary CNS lymphoma is low in most of the lesions reflecting high cellularity, they appear hyper intense on DWI along the different B values and hypo intense on ADC ...
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Diagnostic Accuracy of T1 Weighted Dynamic Contrast Enhanced–MRI and DWI ADC for Differentiation of Glioblastoma and Primary CNS Lymphoma
... MATERIALS AND METHODS: We retrospectively reviewed 18 patients with primary CNS lymphoma and 36 matched patients with glioblastoma with pretreatment DWI and dynamic contrast-enhanced–MR imaging. VOIs ...
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Evaluation of Microvascular Permeability with Dynamic Contrast Enhanced MRI for the Differentiation of Primary CNS Lymphoma and Glioblastoma: Radiologic Pathologic Correlation
... P. Kickingereder, F. Sahm, B. Wiestler, M. Roethke, S. Heiland, H.-P. Schlemmer, W. Wick, A. von Deimling, M. Bendszus, and A. Radbruch ABSTRACT BACKGROUND AND PURPOSE: Dynamic contrast-enhanced MR imaging can provide in ...
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Original Article Corticosteroid pre-treated primary CNS lymphoma: a detailed analysis of stereotactic biopsy findings and consideration of interobserver variability
... of CNS lymphomas, particularly in stereotactic ...25 primary CNS lymphoma cases pre-treated with ...in primary CNS lymphoma was associated with a large spectrum of ...
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Early whole brain radiotherapy in primary CNS lymphoma: negative impact on quality of life in the randomized G-PCNSL-SG1 trial
... with primary CNS lymphoma (PCNSL) has greatly improved: With high-dose methotrexate (HD-MTX)-based chemotherapy as backbone of all efficient therapies, survival has increased and, at least in younger ...
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Primary CNS Lymphoma
... Keywords CNS lymphoma ...Introduction Primary central nervous system lymphoma (PCNSL) is a rare form of non-Hodgkin lymphoma (NHL) comprising ...encompasses lymphoma exclusively ...
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Treatment of primary CNS lymphoma
... STATEMENT: Primary central nervous system lymphoma is a particular challenge in clinical ...the CNS, remains controversial and has not been examined in adequate clinical ...
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Treatment of Primary CNS Lymphoma
... probably too low to reach sufficient concentrations in the CSF to kill lymphoma cells [ 28 , 29 ]. A dose of 8 g/m 2 MTX was frequently associated with the need for a dose reduction during the course of the ...
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Expression of Tim-1 in primary CNS lymphoma
... paraffin- embedded samples of 48 PCNSL (median age 63; age range 16–86 years) and 89 systemic DLBCL patients (median age 67; age range 22–86 years) diagnosed at Kyoto University Hospital, Nagasaki University Hospital, ...
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MR of primary CNS lymphoma in immunologically normal patients
... Primary lymphoma of the central nervous system: com- puterized tomography scan characteristics and treatment results for 12 cases.. Lymphoma and leukemia of.[r] ...
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Radiographic Findings in 32 Cases of Primary CNS Lymphoma
... It was believed that such an angiographic pattern in a dense, homogeneously enhancing parenchymal lesion is suggestive of a primary lymphoma of the central nervous system.. [r] ...
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Relapsed and refractory primary CNS lymphoma: treatment approaches in routine practice
... However, there is much interest in a range of emerging novel therapeutics, including both targeted agents and immunotherapies. Optimizing delivery of therapy to the CNS with renewed attention to negotiating the ...
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