primary macrophages
Effective Inhibition of Kb- and Db-Restricted Antigen Presentation in Primary Macrophages by Murine Cytomegalovirus
... of primary mac- ...in primary macrophages, we used the standard method to differ- entiate macrophages from bone marrow cells by culture in ...our primary BMM cultures were not ...
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IFN-ε protects primary macrophages against HIV infection
... Consistent with previous findings on HIV restriction of SAMHD1 (51, 59), the degree of HIV infec- tion was significantly higher in PMA-differentiated, SAMHD1 knockdown THP1 cells than cells with SAMHD1. SAMHD1 gene ...
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Global Secretome Characterization of Herpes Simplex Virus 1-Infected Human Primary Macrophages
... human primary macrophages using high-throughput quantitative pro- ...HSV-1-infected macrophages, demonstrating that HSV-1 can antagonize inflammasome ...HSV-1-infected macrophages, revealing ...
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Clade Specific Virulence Patterns of Mycobacterium tuberculosis Complex Strains in Human Primary Macrophages and Aerogenically Infected Mice
... human macrophages, there is no general correlation of low cytokine induction with high virulence, since Euro-American Haarlem strains induced high levels of cyto- kines in all donors investigated, associated with ...
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Role of CCR5 in infection of primary macrophages and lymphocytes by macrophage-tropic strains of human immunodeficiency virus: resistance to patient-derived and prototype isolates resulting from the delta ccr5 mutation.
... Primary macrophages lacking CCR5 fail to support proto- type M-tropic ...addition, macrophages and related cells play an im- portant role in the development of neurologic and pulmonary complications ...
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The contribution of peroxynitrite generation in HIV replication in human primary macrophages
... infected macrophages in the pathogenesis and progression of HIV-1 ...of macrophages and microglia ...of macrophages resulted in superoxide and peroxyni- trite production ...HIV-1 macrophages ...
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CXCR4 as a Functional Coreceptor for Human Immunodeficiency Virus Type 1 Infection of Primary Macrophages
... of macrophages derived from homozygous D 32/ D 32 CCR5 ...by primary SI viruses. Macrophages were isolated from blood monocytes by plastic adherence as previously described ...into macrophages ...
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Lentivirus Vectors Using Human and Simian Immunodeficiency Virus Elements
... Lentivirus vectors based on human immunodeficiency virus (HIV) type 1 (HIV-1) constitute a recent devel- opment in the field of gene therapy. A key property of HIV-1-derived vectors is their ability to infect nondividing ...
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Rhinovirus Replication in Human Macrophages Induces NF-κB-Dependent Tumor Necrosis Factor Alpha Production
... previous study which showed a low-grade release of rhinovirus from nondifferentiated THP-1 cells (29). The pattern of infec- tion in THP-1-derived M is similar with that found in respi- ratory epithelial cells, where ...
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A Defect in Influenza A Virus Particle Assembly Specific to Primary Human Macrophages
... to primary macrophages, as the THP1 monocytic cell line differentiated to macrophage-like cells (dTHP1 cells) supports HA-M2 association and efficient IAV ...
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Absence of Appl2 sensitizes endotoxin shock through activation of PI3K/Akt pathway
... Results: In the present study, the role of Appl2 in sepsis shock was investigated by using Appl2 knockout (KO) mice. When challenged with lipopolysaccharides (LPS), Appl2 KO mice exhibited more severe symptoms of ...
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High glucose induces a priming effect in macrophages and exacerbates the production of pro-inflammatory cytokines after a challenge
... THP-1 macrophages under high glucose ...THP-1 macrophages exposed to normal glucose conditions ...human primary macrophages exposed to high glucose regard- ing IL-10 ...
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Influenza Virus Overcomes Cellular Blocks To Productively Replicate, Impacting Macrophage Function
... FITC-positive macrophages by flow ...in macrophages, significantly decreases the percentage of cells that phagocytose the bioparticles compared to uninfected cells ...influenza-infected macrophages. ...
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Akt inhibitors as an HIV 1 infected macrophage specific anti viral therapy
... in primary human macrophages as well as the previous data obtained from the CHME5 cell line [3], we sought to discover the specific molecular mechanisms associated with the cytoprotective effect of HIV-1 ...
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Localization of HIV 1 Vpr to the nuclear envelope: Impact on Vpr functions and virus replication in macrophages
... Results: In order to define the functional role of Vpr localization at the NE, we have characterized a set of single-point Vpr mutants, and selected two new mutants with substitutions within the first α-helix of the ...
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Osteoarthritis associated basic calcium phosphate crystals activate membrane proximal kinases in human innate immune cells
... by primary macrophages in a Syk- and PI3K-dependent manner BCP crystals are known to drive IL-1β production in murine macrophages that have been primed, for ex- ample, with a TLR agonist such as LPS ...
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SAK-HV Promotes RAW264.7 cells Migration Mediated by MCP-1 via JNK and NF-κB Pathways
... to primary macrophages. Given the major role of macrophages in immune system and their correlation with thrombolytic and lipid-lowering effects, it is valuable to clarify the contribution and ...
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Lentivirus Infection in the Brain Induces Matrix Metalloproteinase Expression: Role of Envelope Diversity
... and primary feline macrophages (P ⬍ ...5B) macrophages with RANTES, a -chemokine receptor ligand that has also been shown to activate STAT-1 (10), increased MMP-2 and -9 expression in both U937 ...
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HIV relies on neddylation for ubiquitin ligase mediated functions
... of primary myeloid-derived cells [18-21], and has been shown to act through the CRL4 complex in this capacity ...of macrophages would be inhibited in the pres- ence of MLN4924 if neddylation is important ...
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Tumor necrosis factor participates in the pathogenesis of acute immune complex alveolitis in the rat
... alveolar macrophages are the chief source of ...alveolar macrophages are the primary source of this cytokine, and that TNF participates in the pathogenesis of immune complex alveolitis through ...
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