Primate Model
A nonhuman primate model of chikungunya disease
... Comparison of symptoms resulting from naturally acquired human CHIKV infection and observed symptoms in a laboratory-infected nonhuman pri- mate model of chikungunya disease. In their study in this issue of the ...
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In vitro and in vivo effects of leukotriene B4 antagonism in a primate model of asthma
... nonhuman primate model of asthma. In this model, ani- mals ( Macaca fascicularis ) demonstrate a statistically signifi- cant increase in BAL protein levels, which is indicative of vas- cular leak, ...
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Development of a Novel Nonhuman Primate Model for Rift Valley Fever
... animal model using a non- rodent species such as a nonhuman primate ...hamster model has relied mainly on experimental infection with the related bunyavirus Punta Toro virus (2, 20), where only ...
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An Experimental Group A Streptococcus Vaccine That Reduces Pharyngitis and Tonsillitis in a Nonhuman Primate Model
... animal model to assess vaccine ...nonhuman primate pha- ryngeal infection model as a tool to assess vaccine-induced protection against colonization and clinical symptoms of pharyngitis and ...
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PrPTSE Distribution in a Primate Model of Variant, Sporadic, and Iatrogenic Creutzfeldt-Jakob Disease
... ) following treatment with cadaveric human growth hormone. One primate was inoculated by the intraton- sillar route with 80 l of a 10% British vCJD brain homogenate alone. One animal was infected with a single ...
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Endometrium and endometriosis tissue mitochondrial energy metabolism in a nonhuman primate model
... Additional file 3: Figure S3. Targeted metabolomics experimental design and statistical analysis. Eight clinically healthy and 17 nonhuman primates (NHP) with endometriosis were identified through the Wake Forest ...
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A nonhuman primate model of inherited retinal disease
... nonhuman primate (NHP) closely mirrors that of the human ...National Primate Research Center with visual impairment and findings from clinical ophthalmic examination, advanced retinal imaging, and ...
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Pathogenesis of Influenza A (H5N1) Virus Infection in a Primate Model
... Collectively, our data show that infection of cynomolgus macaques with influenza virus A/HK/156/97 leads to viral replication in the respiratory tract resulting in severe lung damage.. S[r] ...
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Functional CT Perfusion Imaging in Predicting the Extent of Cerebral Infarction from a 3 Hour Middle Cerebral Arterial Occlusion in a Primate Stroke Model
... stroke model that closely mimics the evolution of cerebral ischemia or infarction in hu- ...non- primate species may also be ...a model with neuropatho- logic characteristics similar to those in ...
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Superantigen responsive T cells are required for nasopharyngeal infection by Streptococcus pyogenes
... A major question that has yet to be answered is what biological role do SAgs play in the life cycle of S. pyogenes. SAgs have been primarily associated with severe and invasive diseases [187], however, the high ...
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Evaluation of a killed Rocky Mountain spotted fever vaccine in cynomolgus monkeys
... A nonhuman primate model of Rocky Mountain spotted fever infection was developed in cynomolgus monkeys Macaca fascicularis infected by the subcutaneous route or by aerosol.. Clinical res[r] ...
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Immune profile of an atypical EAE model in marmoset monkeys immunized with recombinant human myelin oligodendrocyte glycoprotein in incomplete Freund’s adjuvant
... EAE model does not accurately reflect the complex immu- nopathology of MS [30] and may explain why the ma- jority of therapies developed in the model are directed against Th1-driven inflammatory ...EAE ...
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Non-Human Primate Models of Enteric Viral Infections
... Abstract: There is an important role non-human primates (NHP) play in biomedical research. Phylogenetic proximity of any of the NHP species to Homo sapiens assures that much better translatability of research outcomes ...
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Experimental autoimmune encephalomyelitis in the common marmoset: a translationally relevant model for the cause and course of multiple sclerosis
... The immunological analysis of the rhMOG/CFA model revealed two distinct pathogenic mechanisms (Fig. 8). We found that the 100 % EAE incidence maps to a common autoimmune mechanism, namely the Caja-DRB*W1201- ...
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Spatially patterned electrical stimulation to enhance resolution of retinal prostheses
... linear model of current summation, consistent with a simple biophysical model based on multiple sites of ...linear model was tested by using the measured responses to stimulation with two electrodes ...
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The common marmoset ( Callithrix jacchus ): a relevant preclinical model of human (auto)immune-mediated inflammatory disease of the brain
... EAE model induced with rhMOG in CFA, CD8 + ve T cells against the MOG40–48 epitope were found to emerge late in the disease, in association with the expres- sion of clinical signs (Kap et ...
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Toward a Neutral Evolutionary Model of Gene Expression
... stochastic model that describes neutral changes of gene expression over evolutionary time as a compound Poisson process where evolutionary events cause changes of expression level according to a given probability ...
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Investigating the Primate Prefrontal Cortex Correlates of Cognitive Deficits In the Ketamine Model of Schizophrenia
... frequently discontinued fixation or did not respond. Furthermore, the errors on anti-saccade trials had reaction times well-above the range of automatic express saccades (80-125 msec) which are directly triggered by the ...
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Transplantation in the nonhuman primate MPTP model of Parkinson’s disease: update and perspectives
... Experiments done in African green monkeys (Cercopithe- cus aethiops sabaeus) all rely on the model developed by Redmond and collaborators (MPTP intramuscular, IM, at 0.2 to 2.15 mg kg −1 typically injected every ...
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Frontal white matter hyperintensities, clasmatodendrosis and gliovascular abnormalities in ageing and post-stroke dementia
... Our study provides strong evidence for another patho- logical substrate which contributes to the development of dementia in post-stroke survivors, most of whom had vas- cular dementia. We found highly increased ...
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