Primitive streak
Determination of embryonic polarity in a regulative system: evidence for endogenous inhibitors acting sequentially during primitive streak formation in the chick embryo
... in primitive streak initiation to date (Vg1, Wnt8C, Nodal, Chordin, FGFs), only the latter can by itself overcome the effects of the inhibitor induced by Vg1, consistent with the idea that FGFs act through ...
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ERK inhibition promotes neuroectodermal precursor commitment by blocking self-renewal and primitive streak formation of the epiblast
... To explore how PD0325901 was involved in PS inhib- ition, we examined the effect of PD0325901 on the Acti- vin A/SMAD and β-catenin pathways during EpiSC differentiation. Our results showed that SMAD2 translo- cated from ...
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Movement and commitment of primitive streak precardiac cells during cardiogenesis
... the primitive streak, employing different experiments with a variety of techniques combining double transplantations, microinjections and ...the primitive streak were found to contribute cells ...
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August Rauber (1841 1917): from the primitive streak to Cellularmechanik
... the primitive streak develops such that the cells appear to arrive at the developing mesoderm from the ventral side of the primitive groove (Rauber 1875a: ...
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The primitive streak gene Mixl1 is required for efficient haematopoiesis and BMP4 induced ventral mesoderm patterning in differentiating ES cells
... enlarged primitive streak due to a failure of progenitor cell migration (Ciruna and Rossant, 2001; Ciruna et ...the primitive streak and showed evidence of perturbed haematopoiesis, with ...
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Tsukushi cooperates with VG1 to induce primitive streak and Hensen's node formation in the chick embryo
... MPS (Ohta et al., 2004). Here, we report on novel observations that provide evidence that TSK controls formation of the chick embryonic axis by also regulating the activity of VG1. We show that alternative splicing of ...
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Antagonism of Nodal signaling by BMP/Smad5 prevents ectopic primitive streak formation in the mouse amnion
... a primitive streak- like structure in the amnion is not the indirect consequence of the absence of Smad5 in ...ectopic primitive streak-like structure in this extra-embryonic ...
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Distinct Wnt-driven primitive streak-like populations reflect in vivo lineage precursors
... early primitive streak characteristics, which is mutually exclusive to a neural-like ...that primitive streak-like EpiSCs are biased towards mesoderm and endoderm fates while retaining ...of ...
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Mouse amnionless, which is required for primitive streak assembly, mediates cell surface localization and endocytic function of cubilin on visceral endoderm and kidney proximal tubules
... phenotypes, however, are less severe. The mutant embryos are very small but undergo gastrulation and produce trunk mesoderm and somites. Although it has not been determined whether the defects in these mutants are solely ...
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Transcriptomic landscape of the primitive streak
... the primitive streak (referred to hereafter as the streak) (Bellairs, 1986; Mikawa et ...The streak is composed mainly of mesoderm precursors, which are still an integral part of the epiblast ...
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The Behaviour of Epiblast Grafts Beneath the Primitive Streak of the Chick
... Host, medium primitive streak stage; donor, the same; graft, a large strip from the level of the front end of the donor primitive streak to the anterior edge of the area pellucida; graft[r] ...
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Fate maps of the primitive streak in chick and quail embryo: ingression timing of progenitor cells of each rostro caudal axial level of somites
... Although the rostral limit of DiI labeling of the series of somites was clear, it distributed caudally with decreasing intensity of fluorescence, so that we could not determine the caudal end derived from the injection ...
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Brachyury cooperates with Wnt/β-catenin signalling to elicit primitive-streak-like behaviour in differentiating mouse embryonic stem cells
... It is thought that ESCs provide a unique model system for interrogating developmental processes in culture [59,60]. However, this possibility rests on the assumption that pro- cesses in tissue culture mimic events in the ...
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The FERM protein Epb4 1l5 is required for organization of the neural plate and for the epithelial mesenchymal transition at the primitive streak of the mouse embryo
... the primitive streak using a pan-Crumbs antibody (Hsu et ...lulu streak, which indicated that these cells had lost this characteristic of the ...
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The Behaviour of Grafts of Primitive Streak Beneath the Primitive Streak of the Chick
... A good complementary induction of part of an axis occurs in QL, where the graft has formed head mesenchyme only, inducing a foregut and headfold as well as a neural plate; and in QC, whe[r] ...
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Induction by the Primitive Streak and its Derivatives in the Chick
... Moreover, specimens 713, 733 and 755, all of which are grafts of the anterior part of the embryonic axis, give clear indications by the formation of a head fold that the induced neural t[r] ...
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Differential requirements for Smad4 in TGFβ dependent patterning of the early mouse embryo
... key intracellular effector of the transforming growth factor β (TGFβ) superfamily of secreted ligands. In mouse, Smad4-null embryos do not gastrulate, a phenotype consistent with loss of other TGFβ-related signaling ...
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Epithelial mesenchymal transitions: the importance of changing cell state in development and disease
... Primary EMT Gastrulation Epiblast Axial mesoderm Embryonic notochord 105 EMT at the primitive streak Paraxial mesoderm somites Skeletal muscles, bones, tendons, satellite cells, compon[r] ...
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Analysis of nephric duct specification in the avian embryo
... Despite their location posterior to the normal nephric duct progenitor region, stage 4-grafted primitive streak cells Fig. 1. Nephric duct markers. (A-F) Stage 11 chick embryos stained by whole-mount in ...
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Refining kidney organoid protocols
... To initiate differentiation, the hiPSCs were grown along with CHIR and noggin for 4 days to drive the cells towards the late primitive streak stage, after which Activin was added to the [r] ...
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