Prion protein gene
Prion Protein Gene and Its Shadow
... Prion protein (PrP) is best known for its involvement in prion ...of prion protein (PrP C ) transforms into a pathogenic, compact isoform (PrP Sc ) during prion disease ...Both ...
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Molecular evolution of the sheep prion protein gene
... Transmissible spongiform encephalopathies (TSEs) are infectious, fatal neurodegenerative diseases characterized by aggregates of modified forms of the prion protein (PrP) in the central nervous system. Well ...
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Clinical and neuropathological phenotype associated with the novel V189I mutation in the prion protein gene
... been linked to the consumption of beef products contami- nated with the agent of the cattle disease, bovine spongi- form encephalopathy [13, 14, 33, 40, 49]. GSS, fCJD, and FFI are caused by mutations within the open ...
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Molecular evolution of the sheep prion protein gene
... The definitive test of whether PRNP nucleotide diversity shows patterns consistent with balancing selection is to compare allele frequency test statistics at PRNP with the distribution of test statistics obtained from ...
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Endoplasmic reticulum stress induces PRNP prion protein gene expression in breast cancer
... Prnp gene expression ...PRNP gene expression has certain implications in cancer because cancers are ER stressed [68] and PrP has been reported to have protective functions that appear to be involved in the ...
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First case of chronic wasting disease in Europe in a Norwegian free-ranging reindeer
... elk prion protein gene [Tg(ElkPrP) mice], but it is noteworthy that the agent signature (as defined by lesion profile) in these mice was different from that in mice inoculated with CWD, suggesting ...
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PrP Gene Polymorphism in Medieval Remains of Sicilian Sheep
... Scrapie disease is a lethal disorder affecting genetically susceptible sheep. The aim of this study was to assess the allelic pattern at codons 136, 141, 154 and 171 in order to estimate whether scrapie was already ...
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Molecular dynamic simulation studies of Q212H, V203G and N173K mutations in prion diseases
... the prion protein gene (PRNP) and a 17 kDa prion protein ...of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical ...
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Biological network inferences for a protection mechanism against familial Creutzfeldt-Jakob disease with E200K pathogenic mutation
... called prion diseases, are rare fatal neurodegenerative disorders that affect humans and ...misfolding prion protein (PrP sc ) affecting the central nervous system (CNS) ...the prion ...
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Familial human prion diseases associated with prion protein mutations Y226X and G131V are transmissible to transgenic mice expressing human prion protein
... human prion protein gene are associated with development of genetic prion diseases in an autosomal dominant pattern with heterogeneous phenotypes ...genetic prion diseases do not always ...
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Prion Strain Characterization of a Novel Subtype of Creutzfeldt-Jakob Disease
... cellular prion protein, which assumes two different major conformations (type 1 and type 2) and, together with the methionine/valine polymorphic codon 129 of the prion protein gene, ...
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Familial Prion Disease Cases Without Mutation in PRNPGene
... Inherited prion disease, which exhibits autosomal dominant inheritance and which accounts for approximately 15% of human TSEs, is caused by germline mutations in the prion protein ...
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The correlation analysis of polymorphisms of Prion-Related Doppel (PRND) with prion (PRNP) alleles in Gansu Alpine Merino sheep
... the prion protein family. The conversion of the normal cellular prion protein (PrPC) to abnormally folded isoform (PrPSc) is the main molecular mechanism of prion diseases including the ...
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Characterization of mutations in <em>PRNP</em> (prion) gene and their possible roles in neurodegenerative diseases
... introduce prion mutations, and their clinical phenotypes and disease phenotypes were also ...Genetic prion disease could occur in different ages: several patients present CJD symptoms at young ages (40s or ...
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Sphingosine Kinase-Dependent Migration of Immature Dendritic Cells in Response to Neurotoxic Prion Protein Fragment
... motaxis is sphingosine kinase dependent suggests that trans- activation of chemotaxis toward sphingosine-1-phosphate, a lysophospholipid that activates cytoskeletal remodeling and motility via ...
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Function of Prion Protein and the Family Member, Shadoo
... Expression of murine Sho gene (Sprn) transgene significantly increased brain Sho protein levels in generated mice (Wang et al., 2011). Following infection with mouse-adapted scrapie strain 22L, all ...
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PubMedCentral-PMC4774245.pdf
... genetic prion disease (Figure ...affect prion disease risk with odds ratios of 3 or greater (60–62), it is not implausible that M232R has a similar effect size, and our data suggest this a more likely ...
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Boesen, Melanie (2005): Entwicklung und Anwendung eines enzymimmunologischen Verfahrens zum Nachweis von zellulärem Prion Protein bei Wiederkäuern. Dissertation, LMU München: Tierärztliche Fakultät
... In der Leber konnte in dieser Arbeit vor allem bei Rindern und Lämmern, sowie in geringerem Maße auch bei Kälbern zelluläres PrP nachgewiesen werden. Dies steht in Einklang mit den Ergebnissen von TICHOPAD et al. (2003), ...
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What is the evidence that tau pathology spreads through prion-like propagation?
... a prion-like trans- synaptic ...of prion-like propagation of non-prion pro- tein aggregates was in infancy ...that prion-like propagation of tau pathology occurs in human brain and underpins ...
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Association analysis of PRNP gene region with chronic wasting disease in Rocky Mountain elk
... assisted gene flow, it is difficult to make any inferences about the genetic diversity of captive versus free-ranging animals from these ...PRNP gene region among Rocky Mountain elk [13], which is ...
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