prion protein (PrP)
Crucial Role for Prion Protein Membrane Anchoring in the Neuroinvasion and Neural Spread of Prion Infection
... of prion diseases is the accumulation in infected tissues of a partially pro- tease-resistant isoform of the prion protein ([PrP] ...protease-sensitive prion pro- tein, PrPsen, which is ...
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The expression of prion protein in the vasculature
... of prion diseases by blood transfusion or through the administration of blood components is of great concern throughout the ...Kingdom. Prion protein is a marker of disease found only in neuronal ...
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Gauczynski, Sabine (2002): Characterization of the 37-kDa/67-kDa laminin receptor as the cell surface receptor for the cellular prion protein. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... mouse prion protein carrying mutations homologous to familial human prion diseases were produced in stably transfected CHO cells and displayed scrapie- like biochemical properties such as proteinase ...
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Prion Protein Gene and Its Shadow
... Prion protein (PrP) is best known for its involvement in prion ...of prion protein (PrP C ) transforms into a pathogenic, compact isoform (PrP Sc ) during prion disease ...Both ...
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Dominant-Negative Inhibition of Prion Formation Diminished by Deletion Mutagenesis of the Prion Protein
... 53. Shmerling, D., I. Hegyi, M. Fischer, T. Blattler, S. Brandner, J. Gotz, T. Rulicke, E. Flechsig, A. Cozzio, C. von Mering, C. Hangartner, A. Aguzzi, and C. Weissmann. 1998. Expression of amino-terminally truncated ...
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Accumulation of proteinase K-resistant prion protein (PrP) is restricted by the expression level of normal PrP in mice inoculated with a mouse-adapted strain of the Creutzfeldt-Jakob disease agent.
... Creutzfeldt-Jakob disease (CJD), a neurodegenerative spongiform encephalopathy of humans, is transmissible iatro- genically (3, 13) and experimentally (21, 32) to rodent animals. Scrapie is a closely related ...
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Formation of Protease-Resistant Prion Protein in Cell-Free Systems
... or prion diseases, the endogenous protease-sensitive prion protein (PrP-sen) of the host is converted to an abnormal pathogenic form that has a characteristic partial protease resistance ...
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Neuronal zinc regulation and the prion protein
... Z inc, the most abundant trace metal in the brain, has numerous func- tions in health and disease. It is released into the synaptic cleft alongside glu- tamate and this connection between zinc and glutamatergic ...
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Preparation of lyophilized recombinant prion protein for TSE diagnosis by RT QuIC
... prescreening, prion strain discrimination, and screening for prion contamination ...vole prion protein appears to be the most practical sub- strate for diagnostic settings due to its ...
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Green fluorescent protein as a reporter of prion protein folding
... of protein fusions as reporters of protein folding and solubility has emerged rapidly and includes use of chloramphenicol acetyltransferase (CAT) [59], β -galactos- idase [60,61] and secretion by defined ...
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Propagation of prion strains through specific conformers of the prion protein.
... Two prion strains with identical incubation periods in mice exhibited distinct incubation periods and different neuropathological profiles upon serial transmission to transgenic mice expressing chimeric Syrian ...
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Sphingosine Kinase-Dependent Migration of Immature Dendritic Cells in Response to Neurotoxic Prion Protein Fragment
... dietary prion protein is followed by transcytosis directly to intraepi- thelial pockets, where key players of the immune system, in- cluding dendritic cells (DCs), are located ...infective prion ...
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Host Determinants of Prion Strain Diversity Independent of Prion Protein Genotype
... the prion protein now have the same amino acid sequence (25, ...the prion phenotype will acquire stable and highly reproducible biological and neuropathological features in the new host ...two ...
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Familial human prion diseases associated with prion protein mutations Y226X and G131V are transmissible to transgenic mice expressing human prion protein
... human prion protein gene are associated with development of genetic prion diseases in an autosomal dominant pattern with heterogeneous phenotypes ...genetic prion diseases do not always fit ...
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Prion protein and its role in signal transduction
... weight protein complexes containing PrP C were isolated and three splice variants of the neural cell adhesion molecule (NCAM) were discovered in the complexes through liquid ...and prion protein ...
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Function of Prion Protein and the Family Member, Shadoo
... by the expression of PrPΔHD mutants, an artificial PrP mutant devoid of internal hydro- phobic domain. Sho can efficiently protect cells against excitotoxin-induced cell death by glutamates. Sho and PrP seem to be ...
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Boesen, Melanie (2005): Entwicklung und Anwendung eines enzymimmunologischen Verfahrens zum Nachweis von zellulärem Prion Protein bei Wiederkäuern. Dissertation, LMU München: Tierärztliche Fakultät
... In der Leber konnte in dieser Arbeit vor allem bei Rindern und Lämmern, sowie in geringerem Maße auch bei Kälbern zelluläres PrP nachgewiesen werden. Dies steht in Einklang mit den Ergebnissen von TICHOPAD et al. (2003), ...
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Expression of prion protein in the cerebrospinal fluid of patients with Parkinson's disease complicated with rapid eye movement sleep behavior disorder.
... and protein levels of PrP were increased in the CSF of PD patients, suggesting a certain correlation between elevated PrP expression and PD, especially in PD patients with ...cellular prion protein ...
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Original Article Expression of prion protein in glioblastoma and related mechanisms
... between prion level and glioblastoma condi- ...interfere prion protein expression for treating brain glioblastoma ...the prion protein level in brain glioblastoma level should be ...
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Cell Biological Studies of the Prion Protein
... of the protein or by intrinsic conformational features of the polypeptide chain. This mechanism may also be operative, based on our observation that some mutant PrP molecules remain resistant to PIPLC cleavage ...
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