Prion Protein (PrPc)
Gauczynski, Sabine (2002): Characterization of the 37-kDa/67-kDa laminin receptor as the cell surface receptor for the cellular prion protein. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... cellular prion protein (Gauczynski et ...glycosylated prion proteins in mammalian cells is essential for a better understanding of the physiological function of PrPc and biochemical processes ...
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Crucial Role for Prion Protein Membrane Anchoring in the Neuroinvasion and Neural Spread of Prion Infection
... of prion diseases is the accumulation in infected tissues of a partially pro- tease-resistant isoform of the prion protein ([PrP] ...protease-sensitive prion pro- tein, PrPsen, which is ...
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Original Article Expression of prion protein in glioblastoma and related mechanisms
... pathogenic protein leading to various nervous diseases, prion protein has not been fully studied in glioblastoma ...between prion protein level and ...over-express prion ...
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Prion Protein Gene and Its Shadow
... Prion protein (PrP) is best known for its involvement in prion ...of prion protein (PrP C ) transforms into a pathogenic, compact isoform (PrP Sc ) during prion disease ...Both ...
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Neuronal zinc regulation and the prion protein
... 9. Jackson GS, Murray I, Hosszu LL, Gibbs N, Waltho JP, Clarke AR, et al. Location and properties of metal- binding sites on the human prion protein. Proc Natl Acad Sci U S A 2001; 98:8531-5; PMID:11438695; ...
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Preparation of lyophilized recombinant prion protein for TSE diagnosis by RT QuIC
... vole prion protein (BV rPrP) was expressed and purified as previously described for the bovine prion protein with slight modification ...pooled protein eluent or resolubi- lized ...
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Propagation of prion strains through specific conformers of the prion protein.
... Two prion strains with identical incubation periods in mice exhibited distinct incubation periods and different neuropathological profiles upon serial transmission to transgenic mice expressing chimeric Syrian ...
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The expression of prion protein in the vasculature
... of prion diseases by blood transfusion or through the administration of blood components is of great concern throughout the ...Kingdom. Prion protein is a marker of disease found only in neuronal ...
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Sphingosine Kinase-Dependent Migration of Immature Dendritic Cells in Response to Neurotoxic Prion Protein Fragment
... dietary prion protein is followed by transcytosis directly to intraepi- thelial pockets, where key players of the immune system, in- cluding dendritic cells (DCs), are located ...infective prion ...
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Boesen, Melanie (2005): Entwicklung und Anwendung eines enzymimmunologischen Verfahrens zum Nachweis von zellulärem Prion Protein bei Wiederkäuern. Dissertation, LMU München: Tierärztliche Fakultät
... In der Leber konnte in dieser Arbeit vor allem bei Rindern und Lämmern, sowie in geringerem Maße auch bei Kälbern zelluläres PrP nachgewiesen werden. Dies steht in Einklang mit den Ergebnissen von TICHOPAD et al. (2003), ...
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Green fluorescent protein as a reporter of prion protein folding
... on protein solubility ...known prion polymorphisms although interestingly residue 84 (mutant M17) is the point of sev- eral octarepeat insertions associated with Gerstmann- Sträussler-Scheinker Syndrome ...
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Familial human prion diseases associated with prion protein mutations Y226X and G131V are transmissible to transgenic mice expressing human prion protein
... familial prion diseases are associated with mutations at 34 different prion protein (PrP) amino acid ...of prion infectivity from a patient expressing truncated human PrP may have implications ...
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Host Determinants of Prion Strain Diversity Independent of Prion Protein Genotype
... the prion protein now have the same amino acid sequence (25, ...the prion phenotype will acquire stable and highly reproducible biological and neuropathological features in the new host ...two ...
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Accumulation of proteinase K-resistant prion protein (PrP) is restricted by the expression level of normal PrP in mice inoculated with a mouse-adapted strain of the Creutzfeldt-Jakob disease agent.
... Creutzfeldt-Jakob disease (CJD), a neurodegenerative spongiform encephalopathy of humans, is transmissible iatro- genically (3, 13) and experimentally (21, 32) to rodent animals. Scrapie is a closely related ...
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Prion protein and its role in signal transduction
... mitogen-activated protein; MEK – MAP/ERK kinase; MHC – major histocompatibility complex; NADPH – nicotinamide adenine dinucleotide phosphate; NCAM – neural cell adhesion molecule; NMDA – N-methyl-D-aspartate; PI3K ...
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Dominant-Negative Inhibition of Prion Formation Diminished by Deletion Mutagenesis of the Prion Protein
... 53. Shmerling, D., I. Hegyi, M. Fischer, T. Blattler, S. Brandner, J. Gotz, T. Rulicke, E. Flechsig, A. Cozzio, C. von Mering, C. Hangartner, A. Aguzzi, and C. Weissmann. 1998. Expression of amino-terminally truncated ...
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Function of Prion Protein and the Family Member, Shadoo
... by the expression of PrPΔHD mutants, an artificial PrP mutant devoid of internal hydro- phobic domain. Sho can efficiently protect cells against excitotoxin-induced cell death by glutamates. Sho and PrP seem to be ...
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Expression of prion protein in the cerebrospinal fluid of patients with Parkinson's disease complicated with rapid eye movement sleep behavior disorder.
... from the mouse model demonstrated that the cleavage of PrP in peripheral nerves induced the activation of myelin repair in Schwann cells and the lack of PrP resulted in demyelination in those cells (Gasperini et al., ...
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Formation of Protease-Resistant Prion Protein in Cell-Free Systems
... or prion diseases, the endogenous protease-sensitive prion protein (PrP-sen) of the host is converted to an abnormal pathogenic form that has a characteristic partial protease resistance ...
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Melanin or a Melanin-Like Substance Interacts with the N-Terminal Portion of Prion Protein and Inhibits Abnormal Prion Protein Formation in Prion-Infected Cells
... Animal study. Both albino B10.C-Tyr ⬍ c ⬎ /Hir (101) and control C57BL/10JMsHir mice were provided by the Riken BRC through the National Bio-Resource Project of the MEXT, Japan. Eight- to ten-week-old B10.C-Tyr ⬍ c ⬎ ...
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