Prodrug therapy
Targeted enzyme prodrug therapy for metastatic prostate cancer – a comparative study of L-methioninase, purine nucleoside phosphorylase, and cytosine deaminase
... enzyme prodrug therapy (ADEPT), gene-directed enzyme prodrug therapy (GDEPT), and viral-directed enzyme prodrug therapy (VDEPT) have been investigated as means to utilize enzymes ...
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Characterization of a fusion protein of RGD4C and the ß-lactamase variant for antibody-directed enzyme prodrug therapy
... enzyme prodrug therapy) is a novel therapeutic approach that targets a tumor enzyme to convert a relatively nontoxic prodrug into an active cytotoxic ...
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Use of horseradish peroxidase for gene-directed enzyme prodrug therapy with paracetamol
... gene therapy strategies have been proposed for the treatment of ...enzyme prodrug therapy, or GDEPT. Gene-directed enzyme prodrug therapy is a two-step process which involves the ...
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Absence of rapid selection for acyclovir or penciclovir resistance following suboptimal oral prodrug therapy of HSV infected mice
... Resistance to acyclovir (ACV) or penciclovir (PCV) gen- erally arises by a single base mutation in either the HSV thymidine kinase (TK) or DNA polymerase (Pol) gene [for a review, see reference [5]]. Unlike Pol, TK is ...
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Targeted antitumor prodrug therapy using CNGRC-yCD fusion protein in combination with 5-fluorocytosine
... Background: The enzyme-prodrug system is considered a promising tool for tumor treatment when conjugated with a targeting molecule. The asparagine-glycine-arginine (NGR) motif is a developing and interesting ...
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Dihydropyrimidine Dehydrogenase Is a Prognostic Marker for Mesenchymal Stem Cell-Mediated Cytosine Deaminase Gene and 5-Fluorocytosine Prodrug Therapy for the Treatment of Recurrent Gliomas
... MSC/CD therapy to recurrent gliomas appears to be a plausible ...cell therapy is costly and carries with it the possible risk of other side effects; hence, the candidate recurrent glioma patients to receive ...
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TARGETED THERAPIES IN CANCER
... enzyme prodrug therapy with the T268G mutant of human carboxypeptidase A1: In vitro and in vivo studies with prodrugs of methotrexate and the thymidylate synthase inhibi- tors GW1031 and ...
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Bacteria in cancer therapy: a novel experimental strategy
... After Coley's initial observations, scientists discovered that certain species of anaerobic bacteria, such as those belonging to the genus Clostridium, thrive and consume oxygen-poor cancerous tissue whereas die when ...
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Prodrug activating systems in suicide gene therapy
... gene therapy, both malignant and nonmalignant cells may be suitable ...gene therapy, in which the genes for toxic products are trans- fected directly into tumor cells; and enzyme-activating prodrug ...
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Gene therapy and cement injection for the treatment of hip prosthesis loosening in elderly patients
... enzyme prodrug therapy is ...the prodrug CB1954 were not toxic to the interface cells at low to intermediate ...and prodrug, given the effect on the transduction of ...
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NOVEL PYRROLO[2,1-C][1,4]BENZODIAZEPINE-b-GLYCOSIDE PRODRUGS FOR SELECTIVE THERAPY OF CANCER AND CONFORMATIONALLY RESTRICTED PBD DIMERS AS DNA BINDING ANTICANCER AGENTS
... enzyme prodrug therapy (ADEPT), gene directed enzyme prodrug therapy (GDEPT) and prodrug mono therapy (PMT) strategies for selective therapy of cancer and recent ...
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Development of a novel enzyme/prodrug system for hypoxia- and radiation-mediated gene therapy of cancer
... enzyme/prodrug therapy (GDEPT) was introduced, whereby the target cells are genetically modified to synthesise an enzyme able to convert a prodrug into a ...gene therapy and the induction o f ...
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GENE THERAPY: RECENT DEVELOPMENT IN THE TREATMENT OF VARIOUS DISEASES
... Gene therapy (use of genes as medicines) is basically to correct defective genes responsible for genetic disorder by one of the following ...Gene therapy states and remains an experimental discipline and ...
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<p>Magnetically Directed Enzyme/Prodrug Prostate Cancer Therapy Based on β-Glucosidase/Amygdalin</p>
... One of the main purposes of targeted enzyme/prodrug strategies is to reduce the toxic effects of coadministration on normal tissues by targeted activation. The key is to administer the prodrug when the ...
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PRODRUG DESIGN: AN OVERVIEW
... The poor drug properties such as solubility, permeability, stability, toxicity, drug targeting are serious challenges for the successful development and commercialization of drug molecules and this is major reason only ...
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<p>Co-Delivery of Paclitaxel and Doxorubicin by pH-Responsive Prodrug Micelles for Cancer Therapy</p>
... The PTX/DOX-PMs were prepared using dialysis method. The particle sizes of DOX-PMs and PTX/DOX-PMs were recorded by DLS, as shown in Figure 2A. The hydrody- namic diameters of DOX-PMs and PTX/DOX-PMs were 102.3 nm and ...
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Dextran: A promising macromolecular drug carrier
... a prodrug of pyrimethamine macromolecules, the resulting conjugate takes form of a namely carboxymethyldextran thiomannopyrannoside colloid in most cases and the protein core gets protected pyrimethamine has been ...
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A double prodrug system for colon targeting of benzenesulfonamide COX 2 inhibitors
... The design, synthesis and delivery potential of a new type of benzenesulfonamide cyclo- oxygenase-2 (COX-2) inhibitor prodrug is investigated using celecoxib. The approach involves a double prodrug that is ...
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<p>Novel lipophilic SN38 prodrug forming stable liposomes for colorectal carcinoma therapy</p>
... philic prodrug of ...lipophilic prodrug on the membrane of liposome ...lipophilic prodrug of SN38 on the structure and the stability of the lipid ...
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<p>Combination Therapy of Lung Cancer Using Layer-by-Layer Cisplatin Prodrug and Curcumin Co-Encapsulated Nanomedicine</p>
... Combination chemotherapy is preferred over treatment with single agents to combat most cancers as it targets multiple cell-survival pathways at the same time and delays the onset of resistance. 11 Combined chemotherapy ...
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