Progression and metastasis
Chemokines in tumor progression and metastasis
... promotes metastasis and organ specific ...tumor progression and ...tumor progression and ...tumor progression and metastasis and thus help in improving survival in cancer ...
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<p>Circular RNA circ_0001105 Inhibits Progression and Metastasis of Osteosarcoma by Sponging miR-766 and Activating YTHDF2 Expression</p>
... Moreover, downregulated-circ_0001105 served as an inde- pendent prognostic factor for OS patients. These fi ndings demonstrate that the circ_0001105 might act as a tumor sup- pressor and contribute to the ...
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Role of SALL4 in the progression and metastasis of colorectal cancer
... not metastasis to lymph nodes being in stage II and all of six samples showed tumor invasion to adventitia (T3), ...with metastasis of tumor cell to lymph node in CRCs, it may be remarkable that ...showed ...
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Roles of SPARC in urothelial carcinogenesis, progression and metastasis
... of metastasis is defined by distinct steps involving local invasion, intravasation into adjacent blood and lymphatic vessels, transit through circulation and evasion of host immune systems, progressive ...
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The critical roles of COUP-TFII in tumor progression and metastasis
... This review has highlighted a critical role of transcrip- tion factor COUP-TFII in tumor progression and metas- tasis. In prostate tumor cells, COUP-TFII counteracts the TGF-β-dependent growth barrier to drive ...
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<p>Dihydroartemisinin Prevents Progression and Metastasis of Head and Neck Squamous Cell Carcinoma by Inhibiting Polarization of Macrophages in Tumor Microenvironment</p>
... and metastasis. 18,27 TAMs can promote progression and metastasis of breast, ovarian, lung, gastric, endometrial, and other ...cancer progression, metastasis, and ...
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Role of inflammasomes and their regulators in prostate cancer initiation, progression and metastasis
... Observations from association studies revealed that non-steroidal anti- inflammatory drugs (NSAIDs) can help to reduce the risk of prostate cancer occurrence [8]. The ability of NSAIDs to inhibit the COX-2 pathway was ...
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<p>The oncogenic role of GNL3 in the progression and metastasis of osteosarcoma</p>
... the progression and metastasis of osteosarcoma via trig- gering cell cycle arrest and apoptosis and down-regulating the MMP9 and EMT process, indicating an oncogenic role of GNL3 in tumor ...
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The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy
... Figure 2 Hypoxia as a driving force of tumor progression and metastasis. Notes: Hypoxia stimulates tumor i) vasculogenesis through endothelial progenitor cells’ mobilization from the bone marrow to the ...
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Upregulation of AKIP1 contributes to metastasis and progression and predicts poor prognosis of patients with colorectal cancer
... Background: A kinase-interacting protein 1 (AKIP1) has been reported to play an important role in the development and progression of cancer. However, the clinicopathological and biological roles of AKIP1 in ...
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<p>Overexpression of COL5A1 promotes tumor progression and metastasis and correlates with poor survival of patients with clear cell renal cell carcinoma</p>
... In this study, overexpression of COL5A1 was observed in ccRCC tissue compared with the paired adjacent normal renal tissue. COL5A1 expression significantly increased with the increase of tumor diameter and tumor stage. ...
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Gene signatures of breast cancer progression and metastasis
... the metastasis suppressor genes BRMS1, KISS1 (kisspeptin), KAI1 (CD82) and Mkk4 (MAP2K4; mitogen-activated protein kinase kinase 4) have been shown in breast cancer brain metastasis [8], with specifi c ...
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Role of Epigenetics in Uveal Melanoma
... Uveal melanoma (UM) is a severe human malignancy with a high mortality rate that demands continued research into new and alternative forms of prevention and treatment. The emerging field of epigenetics is beginning to ...
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A comprehensive overview of exosomes in ovarian cancer: emerging biomarkers and therapeutic strategies
... tumour progression and metastasis has been reported in many of these identified proteins, including membrane proteins (Alix, TSG 101), and tetraspanins (CD24, CD44, CD63, CD37, CD53, CD81), as well as ...
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Rothmeier, Andrea (2008): Anticancer effects and antiangiogenic mechanisms of the marine compound spongistatin 1. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... tumor progression and metastasis at the time point of ...of metastasis by spongistatin 1 is of particular importantance, as 90% of all cancer death arise from the metastatic spread of primary tumors ...
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The role of tumour heterogeneity and clonal cooperativity in metastasis, immune evasion and clinical outcome
... We have begun to witness how tumour heterogeneity affects tumour progression and metastasis, and the tumour immune response. A deeper understanding of how the immune system can be leveraged to tackle clonal ...
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Hypoxia - an explanation of prostate cancer progression mechanisms
... cancer progression and metastasis ...initiation, progression, tumor stemness and resistance to therapy ...tumor progression, metastasis and resistance to common ...
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Orosomucoid 2 inhibits tumor metastasis and is upregulated by CCAAT/enhancer binding protein β in hepatocellular carcinomas
... Based on the IHC results, the expression intensity of the ORM2 protein was scored as 0 or 1 for weak or strong immunostaining, respectively. The analysis showed that ORM2 expression was negatively associated with the ...
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TGF- Sustains Tumor Progression Through
... cells like cancer associated fibroblasts to inhibit tumor progression and metastasis at early stages of 53.. disease ( 13 ).[r] ...
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Solute carrier transporters: potential targets for digestive system neoplasms
... Abstract: Digestive system neoplasms are the leading causes of cancer-related death all over the world. Solute carrier (SLC) superfamily is composed of a series of transporters that are ubiquitously expressed in organs ...
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