proliferation/invasion/metastasis
ADAMTS8 targets ERK to suppress cell proliferation, invasion, and metastasis of hepatocellular carcinoma
... and metastasis in patients with ...inhibited proliferation and migration and induced apoptosis in HepG2 ...growth, invasion, and apoptosis by modulating the ERK signaling ...
10
Decreased expression of peroxiredoxin1 inhibits proliferation, invasion, and metastasis of ovarian cancer cell
... Results: PRDX1 expression was mainly localized to the cytoplasm, as well as the nucleus of cells. The expression rate of PRDX1 in epithelial ovarian malignant tissues (96.04%) was sig- nificantly higher than that in ...
17
Ribosomal protein L34 promotes the proliferation, invasion and metastasis of pancreatic cancer cells
... siRNA. The data revealed that expression of 557 genes differed by at least 2-fold (P < 0.05). Further disease and function analysis revealed that the following particular gene sets that were significantly enriched, ...
14
Carvacrol suppresses proliferation and invasion in human oral squamous cell carcinoma
... the proliferation and induced apoptosis by regulating the cell cycle-associated proteins (P21, CCND1 and CDK4) and apop- tosis-associated proteins (Cox2, Bcl-2, and ...and invasion of Tca-8113 cell lines by ...
8
SU6668 suppresses proliferation of triple negative breast cancer cells through down-regulating MTDH expression
... In the development of solid tumor, angiogenesis is in- sufficient to meet the rapid growth of the tumor blood supply, thus leads to local hypoxia, and up-regulates the expression of HIF-1α. The downstream genes are in- ...
9
Effect of STAT5 silenced by siRNA on proliferation apoptosis and invasion of esophageal carcinoma cell line Eca-109
... the proliferation of Eca-109 ...the proliferation 、 invasion and metastasis of esophageal carcinoma cell line Eca-109, which indicated STAT5 might be a novel therapeutic strategy for the human ...
6
The role of MicroRNAs expression in laryngeal cancer
... MicroRNAs (miRs, miRs) is a class of small non-coding RNAs, which posttran- scriptionally regulate gene expression. Deregulated miRs are frequently obseved in patients with laryngeal cancer. In addition, numerous studies ...
9
A cross-talk between integrin β4 and epidermal growth factor receptor induces gefitinib chemoresistance to gastric cancer
... Integrins are transmembrane receptors that facilitate cell-extracellular matrix (ECM) and cell–cell adhesion. These are important members of the family of adhesion molecules which play important roles in malignant tumor ...
8
Original Article Knockdown of long noncoding RNA UCA1 inhibits glioma cell metastasis via reduction of epithelial-mesenchymal transition
... The current study has investigated the con- served functions of UCA1 on glioma cells viabil- ity, migration and invasion. In esophageal can- cer cells, UCA1 was capable of promoting cell proliferation [19]. ...
6
MicroRNA-195 suppresses tumor cell proliferation and metastasis by directly targeting BCOX1 in prostate carcinoma
... the proliferation, migration and invasion of PCa cells in vitro, and tumor growth and metastasis in ...a metastasis suppressor in ...the metastasis-suppressive miR-195 can target BCOX1 ...
8
Original Article MiR-17 promotes cervical squamous cell tumorigenesis and metastasis by targeting E2F1
... line: proliferation, apoptosis, invasion and metastasis, the potential target gene E2F1 was also proved by western ...cell proliferation by pro- moting cell apoptosis, inhibiting migration and ...
9
Original Article Identification of putative biological targets of KIAA1456 in relation to its inhibition of ovarian cancer cell functions based on microarray profiling
... Ovarian cancer is considered the most deadly gynecological malignancy [1]. Approximately three-fourths of epithelial ovarian cancer cases are detected at an advanced stage [2]. The cur- rent standard of care for ...
11
miR-10b suppresses cell invasion and metastasis through targeting HOXA3 regulated by FAK/YAP signaling pathway in clear-cell renal cell carcinoma
... The HOX3 gene belongs to HOX gene family that is important transcript factors regulating cell proliferation. HOX genes have been demonstrated to impact tumori- genesis directly via diverse mechanisms in cancer ...
10
microRNA-374a suppresses colon cancer progression by directly reducing CCND1 to inactivate the PI3K/AKT pathway
... microRNA-374a (miR-374a) exhibits oncogenic functions in various tumor types. Here we report that miR-374a suppresses proliferation, invasion, migration and intrahepatic metastasis in colon ...
14
The role of kinesin KIF18A in the invasion and metastasis of hepatocellular carcinoma
... In this study, we found that the expression of KIF18A in cancer tissues was higher than that of adjacent tissues. Elevated KIF18A may promote the development of HCC. To further explore the effect of KIF18A on the ...
8
Expression and function of transmembrane 4 superfamily proteins in digestive system cancers
... cell proliferation, invasion and metastasis, we hope to understand what role Tspan7 plays in liver cancer cells [9, ...the proliferation of HCC-LM3 cells but also inhibited the invasion ...
12
Cellular apoptosis susceptibility (CSE1L/CAS) protein in cancer metastasis and chemotherapeutic drug-induced apoptosis
... a proliferation-associated protein and was thought to regulate the proliferation of cancer cells in can- cer ...increase proliferation of cancer cells and CSE1L regulates invasion and ...
9
Original Article TEM1 knock-down inhibits the proliferation and metastasis of MES-SA uterine sarcoma cells
... tumor metastasis and ...Cell proliferation, invasion and metastasis were assessed using Cell Counting Kit (CCK)-8, scratch, transwell and colony formation ...migration, metastasis and ...
10
MiR-203a-3p suppresses cell proliferation and metastasis through inhibiting LASP1 in nasopharyngeal carcinoma
... Cell proliferation, migration and invasion were assessed in vitro by MTT, colony formation and transwell assay, ...cell proliferation, migration and invasion in ...lung metastasis in ...
10
miR-31 affects colorectal cancer cells by inhibiting autophagy in cancer-associated fibroblasts
... miR-31 is a type of common miRNA, and its target genes are involved in the regulation of autophagy, according to a bioinformatic prediction of its target genes. miR-31 plays an important role in the development of ...
12