proliferator-activated receptor γ
Increasing the level of peroxisome proliferator-activated receptor γ coactivator-1α in podocytes results in collapsing glomerulopathy
... peroxisome proliferator-activated receptor γ coactivator-1α (PGC1α, encoded by the gene PPARGC1A) is a transcriptional coactivator that interacts with other transcriptional factors to regulate ...
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Original Article Hepatitis B virus X protein maintains hepatic stellate cell activation by regulating peroxisome proliferator-activated receptor γ
... Peroxisome proliferator-activated receptor γ (PPARγ) inhibits the activation of HSCs and even switches the cell phenotype from activated to ...
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Treatment of insulin resistance with peroxisome proliferator–activated receptor γ agonists
... peroxisome proliferator–activated receptor γ (PPARγ) nuclear receptor (see ...the receptor, the corepressor complex dissociates and a coactivator complex, containing histone ...
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Peroxisome Proliferator-Activated Receptor γ 2 Modulates Late-Pregnancy Homeostatic Metabolic Adaptations
... Pregnancy requires adaptation of maternal energy metabolism, including expansion and functional modifications of ad- ipose tissue. Insulin resistance (IR), predominantly during late gestation, is a physiological ...
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Original Article Association of peroxisome proliferator-activated receptor γ, and gene-gene interactions with essential hypertension in Chinese Han population
... peroxisome proliferator-activated receptor-γ (PPAR γ), and additional gene-gene interaction with essential hypertension (EH) in Chinese Han ...PPAR γ and EH, and additional ...
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Peroxisome proliferator–activated receptor γ ligands inhibit development of atherosclerosis in LDL receptor–deficient mice
... peroxisome proliferator–activated receptor γ (PPARγ) is a nuclear receptor that regulates fat-cell development and glucose homeostasis and is the molecular target of a class of ...
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A Functional Peroxisome Proliferator-activated Receptor-γ Ligand-binding Domain Is Not Required for Adipogenesis
... PPAR ␥ plays a dominant role in fat tissue development. Its importance was initially suggested by its ability to regulate a fat-specific enhancer of the aP2 gene, an adipocyte-specific lip- id-binding protein (2– 4). ...
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Peroxisome proliferator–activated receptor γ coactivator 1 promotes cardiac mitochondrial biogenesis
... peroxisome proliferator–acti- vated receptor γ coactivator-1 (PGC-1) as a regulator of mitochondrial function in tissues specialized for thermogenesis, such as brown ...
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Original Article Gallic acid inhibits LPS induced hypertrophic scar inflammation via toll-like receptor 4/nuclear factor-κB/peroxisome proliferator-activated receptor γ signaling
... PPARs are a family of ligand-activated nuclear transcription factors that have emerged as important factors in organ fibrosis. The present study shows that PPARs regulate important cel- lular functions, including ...
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The pathophysiological function of peroxisome proliferator-activated receptor-γ in lung-related diseases
... PPAR- γ agonists in ...PPAR- γ agonists, 15D-PGJ 2 and ciglitazone dose-dependently blocked the cytokine-induced expres- sion of the inducible form of ...PPAR- γ is expressed and upregulated by IL-4 ...
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A Synthetic Antagonist for the Peroxisome Proliferator-activated Receptor γ Inhibits Adipocyte Differentiation
... served with this construct, suggesting that the ligand-binding domain is the site of BADGE action. Lastly, we wished to determine whether the inhibition of PPAR ␥ by BADGE was selective for this receptor. NIH-3T3 ...
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Assessment of total, ligand-induced peroxisome proliferator activated receptor γ ligand activity in serum
... PPAR γ , a PPRE-driven reporter, and a constitutively ac- tive control ...PPAR γ 1 as the most appropriate ligand target because, compared to PPAR γ 2, PPAR γ 1 is more broadly expressed in ...
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The Effect of Chlamydia pneumoniae on the Expression of Peroxisome Proliferator Activated Receptor γ in Vascular Smooth Muscle Cells
... pro γ - mpted us to investigate the potential synergistic effect of rosiglitazone on the expression of PPAR γ in ...were γ evaluated by Western blot 24 hours after ...HCSMCs. γ Interestingly, ...
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Peroxisome proliferator activated receptor γ agonist effect on rheumatoid arthritis: a randomized controlled trial
... Several lines of evidence support the idea that PPAR-γ agonists have anti-inflammatory effects. PPAR-γ expres- sion in peripheral monocytes and monocyte-derived macrophages in RA patients was inversely ...
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An autoregulatory loop controls peroxisome proliferator-activated receptor γ coactivator 1α expression in muscle
... is activated during exercise by low ATP and high AMP levels (29), and chemical activators of 5⬘ AMP-activated protein kinase have been observed to modestly increase both CaMKIV and PGC-1␣ mRNA levels in ...
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Increased hepatic oxidative metabolism distinguishes the action of Peroxisome proliferator-activated receptor δ from Peroxisome proliferator-activated receptor γ in the ob/obmouse
... PPAR γ , then the current study will saturate the PPAR δ receptor whilst only minimally activating the other PPAR isotypes ...dihomo- γ -linole- nate increased but arachidonate was ...
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Responses to temperature variation: integration of thermoregulation and metabolism in vertebrates
... peroxisome proliferator activated receptor γ coactivator 1 α (PGC-1 α ), which modulates metabolism in response to multiple stimuli such as exercise, diet and temperature (Puigserver et ...
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Fenretinide inhibits macrophage inflammatory mediators and controls hypertension in spontaneously hypertensive rats via the peroxisome proliferator-activated receptor gamma pathway
... Abstract: Fenretinide is a novel anticancer agent reported to exhibit anti-invasive and antimetastatic activities. It has also been shown to improve obesity and diabetes, although the effects of fenretinide on ...
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Activation of peroxisome proliferator– activated receptor gamma induces anti-inflammatory properties in the chicken free avian respiratory macrophages
... of activated macrophages to clear inflammatory stimuli with diminished production of proinflammatory cytokines ...PPAR γ ligands during phagocytosis in the FARM, we treated lipopolysaccharide ...
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Telmisartan directly ameliorates the neuronal inflammatory response to IL-1β partly through the JNK/c-Jun and NADPH oxidase pathways
... peroxisome proliferator-activated receptor gamma (PPAR γ ) gene expression, but strongly inhibited the expression of the PPAR γ target genes ABCG1 and ...PPAR γ , ABCG1 and CD36 ...
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