prolyl hydroxylase
Pseudomonas expression of an oxygen sensing prolyl hydroxylase homologue regulates neutrophil host responses in vitro and in vivo
... as evidenced by the reduction in cell loss we observed when neutrophils were challenged with P. aeruginosa conditioned media in the context of hypoxia. Thus in clinical scenarios in which tissue oxygen availability is ...
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Preconditioning of bone marrow mesenchymal stem cells by prolyl hydroxylase inhibition enhances cell survival and angiogenesis in vitro and after transplantation into the ischemic heart of rats
... the prolyl hydroxylase inhibitor DMOG prevents acute damage in the ischemic heart and brain as well as ameliorating BMSC cell death under pathological conditions ...
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Loss of prolyl hydroxylase domain protein 2 in vascular endothelium increases pericyte coverage and promotes pulmonary arterial remodeling
... Prolyl hydroxylase domain proteins (PHD) are the oxygen sensing molecules that form a complex von Hippel-Lindau protein (VHL) and degrade hypoxia inducible factor-α (HIF-α) ...HIF-α hydroxylase ...
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Prolyl hydroxylase 2 (PHD2) inhibition protects human renal epithelial cells and mice kidney from hypoxia injury
... Prolyl hydroxylase domain protein 2 (PHD2) is a key oxygen sensor, setting low steady-state level of hypoxia-inducible factor-α (HIF-α). Here, we showed that treatment of cobalt chloride (CoCl 2 ), a ...
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Hyperplasia and hypertrophy of pulmonary neuroepithelial bodies, presumed airway hypoxia sensors, in hypoxia-inducible factor prolyl hydroxylase-deficient mice
... Abstract: Pulmonary neuroepithelial bodies (NEBs), presumed polymodal airway sensors, consist of innervated clusters of amine (serotonin) and peptide-producing cells. While NEB responses to acute hypoxia are mediated by ...
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Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses
... A tightly coordinated innate immune response is critical for effec- tive pathogen clearance with limited collateral tissue damage. There is a clinical need for therapies that selectively target exces- sive or ...
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A Toxoplasma Prolyl Hydroxylase Mediates Oxygen Stress Responses by Regulating Translation Elongation
... a prolyl hydroxylase conserved among apicompl- ...that prolyl hydroxylate elongation factor Tu (12, 19), because their more divergent sequences are potentially ancestral to the other ...
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Prolyl hydroxylase domain 3 influences the radiotherapy efficacy of pancreatic cancer cells by targeting hypoxia-inducible factor-1α
... modalities. Prolyl hydroxylase domain 3 (PHD3) is a rate-limiting enzyme that regulates the degradation of hypoxia-inducible factors (HIFs) and is deregulated in pancreatic cancer ...
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Therapeutic inhibition of prolyl hydroxylase domain-containing enzymes in surgery: putative applications and challenges
... Abstract: Oxygen is essential for metazoans to generate energy. Upon oxygen deprivation adaptive and protective pathways are induced, mediated by hypoxia-inducible factors (HIFs) and prolyl hydroxylase ...
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An electrochemical sensor based on a graphene/AuNP nanocomposite for the determination of prolyl hydroxylase
... Prolyl hydroxylase (PHD1) is a vital indicator of a patient’s health level evaluation after liver metastases. The present study reports the fabrication of a state-of-the-art and highly conductive ...
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The ribosomal prolyl-hydroxylase OGFOD1 decreases during cardiac differentiation and modulates translation and splicing
... Protein prolyl-hydroxylases are a family of enzymes dependent on oxygen and α-ketoglutarate that catalyze hydroxylation of amino acid residues, such as prolines or asparagines ...ribosomal ...
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Prolyl hydroxylase domain enzymes: important regulators of cancer metabolism
... Phd, prolyl hydroxylase domain proteins; PHi, Phd inhibitor; RNA, ribonucleic acid; RNAi, RNA interference; Sca1, stem cell antigen-1; SCG, superior cervical ganglion; siRNA, small interfering RNA; Tie2, ...
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Induction of erythropoiesis by hypoxia-inducible factor prolyl hydroxylase inhibitors without promotion of tumor initiation, progression, or metastasis in a VEGF-sensitive model of spontaneous breast cancer
... confirmed the sensitivity of this model to increased vascular endothelial growth factor (VEGF), using bigenic NeuYD;MMTV-VEGF-25 mice. Tumor initiation was dramatically accelerated in bigenic animals. Bigenic tumors were ...
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Prolyl hydroxylase domain 2 deficiency promotes skeletal muscle fiber-type transition via a calcineurin/NFATc1-dependent pathway
... abrogate Prolyl hydroxylase domain protein (PHD) 2 responsible for HIF-1 α hydroxylation making HIF-1 α susceptible to ubiquitin dependent degradation by ...
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Nanovector-based prolyl hydroxylase domain 2 silencing system enhances the efficiency of stem cell transplantation for infarcted myocardium repair
... RNA-mediated prolyl hydroxylase domain protein 2 (PHD2) silencing in MSCs holds tremendous potential to enhance their survival and paracrine effect after ...
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Born to sense: biophysical analyses of the oxygen sensing prolyl hydroxylase from the simplest animal <em>Trichoplax adhaerens</em>
... In addition to their overall structural conservation, the prolyl-4-hydroxylases adopt strikingly similar substrate- binding features (Figures 4–6 and S5). The TaODD, HsHIF1α CODD/NODD, EF-Tu, and the proline-rich ...
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Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice
... The regulation of neutrophil lifespan by induction of apoptosis is critical for maintaining an effective host response and preventing excessive inflammation. The hypoxia-inducible factor (HIF) oxygen-sensing pathway has ...
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Prolyl-hydroxylase 3: evolving roles for an ancient signaling protein
... Notes: Column 1 lists all non-HiF proteins known to be targets of and/or that interact with PHD3. The specific prolines targeted for hydroxylation are listed (if applicable). Column 2 lists the methods used to determine ...
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The prolyl hydroxylase enzymes are positively associated with hypoxia inducible factor 1α and vascular endothelial growth factor in human breast cancer and alter in response to primary systemic treatment with epirubicin and tamoxifen
... Methods: The expression of PHD1, PHD2 and PHD3 together with HIF-1a and the HIF-inducible genes vascular endothelial cell growth factor VEGF and carbonic anhydrase IX were assessed by im[r] ...
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Differential expression of prolyl hydroxylase 1 in patients with ulcerative colitis versus patients with Crohn’s disease/infectious colitis and healthy controls
... The expression level of the PHD3 gene was signifi- cantly elevated in samples taken from inflamed colonic areas in UC patients compared to samples from HC (p < 0.0001). A) Protein exp[r] ...
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