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promoter mutations

Frequent somatic TERT promoter mutations and CTNNB1 mutations in hepatocellular carcinoma

Frequent somatic TERT promoter mutations and CTNNB1 mutations in hepatocellular carcinoma

... somatic mutations in the TERT promoter have been frequently identified in HCC ...TERT promoter mutations in HCC has been reported to be 44~59% [8- ...TERT promoter mutations are ...

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Frequency and geographic distribution of TERT promoter mutations in primary hepatocellular carcinoma

Frequency and geographic distribution of TERT promoter mutations in primary hepatocellular carcinoma

... 61. Killela PJ, Reitman ZJ, Jiao Y, Bettegowda C, Agrawal N, Diaz Jr LA, Friedman AH, Friedman H, Gallia GL, Giovanella BC, Grollman AP, He TC, He Y, Hruban RH, Jallo GI, Mandahl N, Meeker AK, Mertens F, Netto GJ, ...

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Analysis of SDHD promoter mutations in various types of melanoma

Analysis of SDHD promoter mutations in various types of melanoma

... SDHD promoter mutation status with overall survival was seen (Figure ...SDHD promoter mutations not affecting ETS binding sites), meaning larger studies will be required to convincingly assess ...

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Implications of TERT promoter mutations and telomerase activity for urothelial carcinogenesis

Implications of TERT promoter mutations and telomerase activity for urothelial carcinogenesis

... cancer-initiating mutations, such as oncogene activation (leading to OIS) or aneuploidy-inducing mutations (leading to AIS), would interfere with cell fitness and would induce premature senescence as a ...

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TERT promoter mutations and polymorphisms as prognostic factors in primary glioblastoma

TERT promoter mutations and polymorphisms as prognostic factors in primary glioblastoma

... The genotype distributions in controls was tested and found to be in Hardy-Weinberg equilibrium. The association between each SNP and risk of glioblastoma was assessed by Odds ratios (OR) with 95% confidence intervals ...

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Telomerase promoter mutations in human immunodeficiency virus related conjunctiva neoplasia

Telomerase promoter mutations in human immunodeficiency virus related conjunctiva neoplasia

... 15. Killela PJ, Reitman ZJ, Jiao Y, Bettegowda C, Agrawal N, Diaz LA Jr, Fried- man AH, Friedman H, Gallia GL, Giovanella BC, Grollman AP, He TC, He Y, Hruban RH, Jallo GI, Mandahl N, Meeker AK, Mertens F, Netto GJ, ...

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TERT promoter mutations and telomere length in adult malignant gliomas and recurrences

TERT promoter mutations and telomere length in adult malignant gliomas and recurrences

... TERT promoter mutations occur mainly at –124 bp and –146 bp positions from ATG start site of TERT ...reported mutations in the TERT promoter including the causal –57 C > A germline single ...

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Attenuation of Influenza A Virus mRNA Levels by Promoter Mutations

Attenuation of Influenza A Virus mRNA Levels by Promoter Mutations

... containing promoter mutations in the NA segment and growth ...with mutations in the double- stranded region of the panhandle/RNA-fork (8, 14) in order to study the effects of mutations on ...

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Association of telomerase reverse transcriptase promoter mutations with clinicopathological features and prognosis of thyroid cancer: a meta-analysis

Association of telomerase reverse transcriptase promoter mutations with clinicopathological features and prognosis of thyroid cancer: a meta-analysis

... (TERT) promoter mutations have been widely investigated in thyroid cancer; however, the results are still ...TERT promoter mutations tended to present in aggressive histological types ...

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Clinical Significance of Hepatitis B Virus (HBV) Genotypes and Precore and Core Promoter Mutations Affecting HBV e Antigen Expression in Taiwan

Clinical Significance of Hepatitis B Virus (HBV) Genotypes and Precore and Core Promoter Mutations Affecting HBV e Antigen Expression in Taiwan

... core promoter mutations in Taiwan, a cohort of 200 Taiwanese chronic hepatitis B patients was ...core promoter regions were determined in 66 asymptomatic carriers and 134 patients who had liver ...

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Typing of HVR, Frequency of blaZ, and Detection of mecA Promoter Mutations in Clinical Isolates of Methicillin-Resistant Staphylococcus aureus

Typing of HVR, Frequency of blaZ, and Detection of mecA Promoter Mutations in Clinical Isolates of Methicillin-Resistant Staphylococcus aureus

... [1] Goudarzi H, Seyedjavadi SS, Udo EE, Beiranvand E, Fazeli M, Goudarzi M. Molecular characterization and distribution of Class 1 integron-bearing methicillin resistant Staphylococcus aureus strains in burn patients, ...

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Frequent DPH3 promoter mutations in skin cancers

Frequent DPH3 promoter mutations in skin cancers

... somatic mutations within regulatory elements of the ...somatic mutations in skin cancers in a bidirectional promoter of diphthamide biosynthesis 3 (DPH3) and oxidoreductase NAD-binding domain ...

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Frequency of TERT promoter mutations in prostate cancer

Frequency of TERT promoter mutations in prostate cancer

... core promoter region of the TERT gene in a comprehensive and representative cohort of PrCa ...TERT promoter mutations are not involved in the development of PrCa as no mutation was detected in any of ...

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Germline TERT promoter mutations are rare in familial melanoma

Germline TERT promoter mutations are rare in familial melanoma

... germline mutations and previously reported showing that persons with germline POT1 mutations associated with dominantly inherited susceptibility to melanoma had increased telomere length with these assays ...

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Telomerase reverse transcriptase promoter mutations in a cohort of adult gliomas: Clinicopathological correlates

Telomerase reverse transcriptase promoter mutations in a cohort of adult gliomas: Clinicopathological correlates

... There have been a myriad new mutations and genetic alterations that have been discovered over the past few decades, and attempts to classify them into prognostic categories are ongoing. One substantial step has ...

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Somatic mutations in telomerase promoter counterbalance germline loss of function mutations

Somatic mutations in telomerase promoter counterbalance germline loss of function mutations

... the promoter mutations have probably been acquired by progenitors that have undergone clonal ...TERT promoter mutations are linked to clonal V (D)J ...activating promoter muta- tion on ...

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MED12, TERT promoter and RBM15 mutations in primary and recurrent phyllodes tumours

MED12, TERT promoter and RBM15 mutations in primary and recurrent phyllodes tumours

... TERT promoter mutations are rare in ...these mutations are also present in paired recurrences or whether there is evidence of temporal ...TERT promoter mutation that are consistently found in ...

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Hepatitis B Virus Genotype C Isolates with Wild-Type Core Promoter Sequence Replicate Less Efficiently than Genotype B Isolates but Possess Higher Virion Secretion Capacity

Hepatitis B Virus Genotype C Isolates with Wild-Type Core Promoter Sequence Replicate Less Efficiently than Genotype B Isolates but Possess Higher Virion Secretion Capacity

... core promoter mutations, which increase genome replication and are independently associated with poor clinical ...core promoter mutations were prevalent in genotype C isolates and correlated ...

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Determinants for the Occurrence of Acute Exacerbation of Hepatitis B Virus Infection in Chinese Patients after HBeAg Seroclearance

Determinants for the Occurrence of Acute Exacerbation of Hepatitis B Virus Infection in Chinese Patients after HBeAg Seroclearance

... core promoter mutations were determined by a line probe ...core promoter mutations at the time of HBeAg seroclearance were independently associated with the occurrence of acute exacerbation ...

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Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies

Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies

... TERT promoter mutations, while low frequencies were noted in gastric cancer, pan- creatic cancer, non-small-cell lung cancer and gastro- intestinal stromal tumors [6, 45, ...moter mutations to ...

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