Promoter polymorphisms
The algorithm for Alzheimer risk assessment based on APOE promoter polymorphisms
... gene polymorphisms in the transcriptional regulatory regions of the gene —the −1000 to +400 proximal promoter region in particular—were in- vestigated ...single-nucleotide polymorphisms (SNPs) were ...
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Analysis of MMP2 promoter polymorphisms in childhood obesity
... This paper reports for the first time the role of MMP-2 promoter polymorphisms in childhood obesity as mea- sured using PBF. Although we were unable to demon- strate an association for the 3 SNPs ...
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Clinical relevance of the interleukin 10 promoter polymorphisms in Chinese Han patients with major trauma: genetic association studies
... IL-10 promoter polymorphisms Blood specimens were collected in tripotassium ethylenedi- amine tetraacetic acid sterile tubes from trauma patients immediately after admission (generally within 10 hours after ...
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Liver X receptors alpha gene (NR1H3) promoter polymorphisms are associated with systemic lupus erythematosus in Koreans
... Pharmacological treatment and reporter gene assay Hep3B and COS-7 cells were transfected with NR1H3 promoter pGL3-basic constructs using FuGENE6 (Promega) according to the manufacturer’s instructions. After ...
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The prognostic value of the suPARnostic®ELISA in HIV 1 infected individuals is not affected by uPAR promoter polymorphisms
... uPAR promoter was sequenced in 52 individuals cov- ering the active promoter from -643 bp upstream to +159 bp downstream of the transcription start ...
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TGFB1 Gene Promoter Polymorphisms in Serbian Asthmatics
... ease, the patients were subgrouped according to exacerbations of their asthmatic symptoms. Exacer- bations of asthma are acute or subacute episodes of progressive increase in shortness of breath, cough, wheezing or chest ...
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The role of <em>PAX9</em> promoter gene polymorphisms in causing hypodontia: a study in the Jordanian population
... Background: The congenital absence of one or few teeth, hypodontia, is considered one of the utmost dental ageneses in human beings. Several genes have been shown to be involved in the development of hypodontia such as ...
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Human genetic susceptibility to mother to child transmission of HIV : a study of mother-infant pairs in Malawi
... Furthermore, genetic variants of the CCR5 gene such as the 32-basepair deletion in the open reading frame the CCR5 gene (CCR5 ∆ 32) or promoter polymorphisms are associated with varia[r] ...
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Human Cancer Xenografts in Outbred Nude Mice Can Be Confounded by Polymorphisms in a Modifier of Tumorigenesis
... linked polymorphisms in the promoter, noncoding and coding sequences of Pla2g2a and show that outbred nude mice from different commercial providers are heteroge- neous for this polymorphic Pla2g2a ...show ...
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Review Article Association between interleukin-18 gene promoter (rs1946518 and rs187238) polymorphisms and susceptibility to chronic hepatitis B virus infection: a systematic review with meta-analysis
... gene promoter (rs1946518 or rs187238) polymorphisms and susceptibility to chronic hepatitis B virus (HBV) ...gene promoter polymorphisms and chronic HBV ...in promoter region was ...
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Association of a specific haplotype across the genes MMP1 and MMP3 with radiographic joint destruction in rheumatoid arthritis
... relevant promoter polymorphisms of MMP1 and MMP3 were genotyped in 308 patients and in 110 controls, to test whether the polymorphisms contribute to the severity of the disease measured by ...
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Interferon-Gamma Gene Polymorphism in Patients with Tuberculosis
... 12- Bulat-Kardum L, Etokebe GE, Knezevic J, Balen S, Matakovic-Mileusnic N, Zaputovic L, etal. Interferon- gamma receptor-1 gene promoter polymorphisms (G-611A; T-56C) and susceptibility to tuberculosis. ...
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The correlations between DNA methylation and polymorphisms in the promoter region of the human telomerase reverse transcriptase (hTERT) gene with postoperative recurrence in patients with thyroid carcinoma (TC)
... recurrence group. DNA methylation is one of the mecha- nisms that can instigate gene silencing in the process of carcinogenesis, especially in tumor suppressor genes [35]. Expression of hTERT still remains as one of the ...
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Imputation accuracy of bovine spongiform encephalopathy associated PRNP indel polymorphisms from middle density SNPs arrays
... Together with the development of high through- put genotyping methods, especially whole-genome genotyping microarrays, the idea of genomic se- lection is being introduced to the daily animal breeding (Hayes et al., ...
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Polymorphisms in the vascular endothelial growth factor gene and breast cancer in the Cancer Prevention Study II cohort
... VEGF polymorphisms may play a role in breast cancer progression, results are shown sepa- rately for in situ breast cancer and invasive breast cancer, as well as for all breast cancers ...four polymorphisms ...
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HLA-A33 Is Associated With Susceptibility to Enterovirus 71 Infection
... IL-6 promoter, IL-1  promoter, and CTLA-4 among the control subjects, as well as the EV71 case subjects, did not differ significantly from Hardy-Wein- berg ...the polymorphisms of the candidate ...
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TERT promoter mutations and polymorphisms as prognostic factors in primary glioblastoma
... TERT promoter is frequently found in human melanomas and also other human cancers and cell lines [8, ...TERT promoter activity, by putatively generating consensus binding sites (GGAA) for ETS transcription ...
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Genes, inflammation, and age-related diseases
... the promoter region of the IL-10 gene influences the production levels of IL-10, this variation can also be related to cardiovascular disease and/or cognitive ...
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Is FKBP5 a genetic marker of affective psychosis? A case control study and analysis of disease related traits
... of depressive episodes, although our sample had a mean follow-up history of >10 years and a mean number of five episodes requiring in-patient treatment. We assessed these comprehensive clinical data in a retrospective ...
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Low apolipoprotein M serum levels correlate with Systemic lupus erythematosus disease activity and apolipoprotein M gene polymorphisms with Lupus
... the promoter region of APOM with SLE risk has not been reported ...the promoter region of APOM could be a causative genetic factor in the risk for developing SLE in a Chinese ...
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