Promyelocytic Leukemia
Functional Reorganization of Promyelocytic Leukemia Nuclear Bodies during BK Virus Infection
... Promyelocytic leukemia nuclear bodies (PML-NBs), also known as nuclear domains 10 (ND10), nuclear dots, or PML on- cogenic domains (PODs), represent a potential obstacle for BKV ...acute ...
10
Molecular mechanisms of cisplatin cytotoxicity in acute promyelocytic leukemia cells
... Acute promyelocytic leukemia (APL) is a blood cancer usually formed through chromosomal translocation between chromosomes 15 and 17 inside the bone marrow during blood ...myeloid leukemia (AML) ...
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Retinoic acid and arsenic trioxide in the treatment of acute promyelocytic leukemia: current perspectives
... Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia (AML) with a unique morphological appearance, associated coagulopathy and canonical bal- anced translocation of ...
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Cyclic Nucleotide induced Maturation of Human Promyelocytic Leukemia Cells
... A subpopulation of cultured human promyelocytic leukemia cells HL60 display the formyl peptide chemotactic receptor.. Development of chemotactic responsiveness in myeloid precursor cells[r] ...
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Immunohistochemical expression of promyelocytic leukemia body in soft tissue sarcomas
... Background: The function of promyelocytic leukemia (PML) bodies is not well known but plays an important role in controlling cell proliferation, apoptosis and senescence. This study was undertaken to ...
8
Induction treatments for acute promyelocytic leukemia: a network meta-analysis
... (“acute promyelocytic leukemia” OR “APL” OR “M3”) and (“treatment” “therapy” OR “medicine” OR “chemotherapy” OR “CT” OR “all- trans retinoic acid” OR “ATRA” OR “arsenic trioxide” OR “ATO” OR “Realgar-Indigo ...
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Assembly of Epstein-Barr Virus Capsid in Promyelocytic Leukemia Nuclear Bodies
... with promyelocytic leukemia (PML) nuclear bodies (NBs) in P3HR1 cells during the viral lytic cycle, appearing as nuclear speckles under a confocal laser scanning ...
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Acute promyelocytic leukemia with the translocation t(15;17)(q22;q21) associated with t(1;2)(q42~43;q11 2~12): a case report
... myeloid leukemia; APL, acute promyelocytic leukemia; ATRA, all-trans retinoic acid; DAPI, (4 ′ ,6- diamino-2-phenylindole); D-FISH, dual-color fluorescence in situ hybridization; DIC, disseminated ...
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Rearrangements of the retinoic acid receptor alpha and promyelocytic leukemia zinc finger genes resulting from t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia
... acute promyelocytic leukemia (APL) showed an unusual karyotype 46,xy,t(11;17) (q23;21) without apparent rearrangement of chromosome ...the promyelocytic leukemia gene consistent with ...
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“In Vitro Cytotoxic Effect of Indole Alkaloids from the Roots of Kopsia singapurensis RIDL. against the Human Promyelocytic Leukemia (HL-60) and the Human Cervical Cancer (HeLa) Cells” by Halimatussakdiah, Ulil Amna, Siow-Ping Tan, Khalijah Awang, Abdul Manaf Ali, Mohd Azlan Nafiah, Kartini Ahmad, Malaysia.
... Six indole alkaloids; kopsamine N(4)-oxide 1, kopsifine 2, rhazinicine 3, aspidodasycarpine 4, kopsamine 5 and akuammidine 6, were isolated from the roots of Kopsia singapurensis Ridl. (Apocynaceae). Compound 2 is first ...
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Promyelocytic leukemia protein isoform II inhibits infection by human adenovirus type 5 through effects on HSP70 and the interferon response
... Atwan, Zeenah, Wright, Jordan L., Leppard, Keith and Woodman, Andrew. (2016) Promyelocytic leukemia protein isoform II inhibits infection by human adenovirus type 5 through effects on HSP70 and the ...
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<p>A rare case of acute promyelocytic leukemia with IRF2BP2-RARA fusion; and literature review</p>
... Acute promyelocytic leukemia (APL) is characterized by the fusion of retinoic acid receptor alpha (RARA) with promyelocytic leukemia ...
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Synergistic decrease of clonal proliferation, induction of differentiation, and apoptosis of acute promyelocytic leukemia cells after combined treatment with novel 20 epi vitamin D3 analogs and 9 cis retinoic acid
... acute promyelocytic leukemia (APL) usually relapse after all-trans retinoic acid (RA) treatment because this therapy fails to eradicate the malignant ...
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A review of arsenic trioxide and acute promyelocytic leukemia.
... 3. Chen GQ, Zhu J, Shi XG, Ni JH, Zhong HJ, Si GY, et al. In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: As2O3 induces ...
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Promyelocytic Leukemia Protein (PML) Controls Listeria monocytogenes Infection
... ABSTRACT The promyelocytic leukemia protein (PML) is the main organizer of stress-responsive subnuclear structures called PML nuclear bodies. These structures recruit multiple interactors and modulate their ...
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Molecular characteristics and chromatin texture features in acute promyelocytic leukemia
... In the univariate Cox analysis, a higher leukocyte count, FLT3 -ITD mutation, microgranular morphology, methylation of CDKN2B , besides a higher local homogeneity of nuclear chromatin, a[r] ...
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Advances in the drug therapies of acute myeloid leukemia (except acute promyelocytic leukemia)
... myeloid leukemia (AML) is a heterogeneous hematologic malignancy, characterized by the clonal expansion of myeloid blasts in the peripheral blood, bone marrow, and/or other ...
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Gene and protein analysis reveals that p53 pathway is functionally inactivated in cytogenetically normal Acute Myeloid Leukemia and Acute Promyelocytic Leukemia
... A possible mechanism for p53 pathway inactivation is in- hibition of p53 transcriptional activity by Mdmx [31, 32]. Indeed, our Real-Time PCR analysis revealed upregulation of Mdmx gene expression in CN-AML, though ...
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Congenital Hypoplastic Anemia Terminating in Acute Promyelocytic Leukemia
... different from pure RBG aplasia of adults and aplastic anemia.3 While the latter two conditions have been known to terminate in acute leukemia, we could find no recorded case in the Engl[r] ...
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Effects of Promyelocytic Leukemia Protein on Virus-Host Balance
... acute promyelocytic leuke- mia (19, 39, 43) as well as after several viral infections in vitro (herpes simplex virus type 1, human cytalomegalovirus, ade- novirus type 5, human immunodeficiency virus, and lympho- ...
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