proof-of-principle
Efficacy of dehydroepiandrosterone to overcome the effect of ovarian ageing (DITTO): a proof of principle randomised controlled trial protocol
... The trial is designed to test the ‘ proof of principle ’ that DHEA priming improves the ovarian response to supero- vulation. The primary outcome is the total number of oocytes retrieved. Only the fi rst ...
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Effect of Zoledronic Acid and Denosumab in patients with low back pain and modic change: A proof of principle trial
... this proof of principle study, one-off treatment with either infusion of ZA (5mg/100ml) or subcutaneous injection of denosumab (60mg/1ml) were effective for the treatment of MC- associated LBP assessed by ...
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Human genetics of infectious diseases: between proof of principle and paradigm
... provided proof of principle that infectious diseases may result from various types of inborn errors of immunity, the genetic determinism of most infectious diseases in most patients remains ...
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Adenovirus-mediated expression of ribozymes in mice.
... demonstrates proof of principle that (i) somatic gene transfer resulting in the expression of ribozymes is possible and (ii) the level of ribozyme expression correlates with the ability to spe- cifically ...
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Impairment targeted exercises for older adults with knee pain: protocol for a proof of principle study
... the principle that a home-based exercise programme, specifically targeted at particular physical impairments of muscular weak- ness, decreased flexibility and poor balance, can posi- tively influence those ...
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Optically generated hyperpolarization for sensitivity enhancement in solution state NMR spectroscopy
... for proof of principle to demonstrate gains on the solvent peak, 11,12,34 but Overhauser polarization transfer to water-solubilized sub- strates is ...
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Noninvasive imaging of pancreatic islet inflammation in type 1A diabetes patients
... a proof of principle for this approach, imaging of infused ferumoxtran-10 nanoparticles permitted effective visualization of the pancreas and distinction of recent-onset diabetes patients from non- diabetic ...
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Opening the toolkit for genetic analysis and control of Anopheles mosquito vectors
... first proof of principle for a gene drive in anophelines was based on the expression of the homing nuclease I-SceI [27] targeting a modified transgenic ...
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Impairment targeted exercises for older adults with knee pain: a proof of principle study (TargET Knee Pain)
... The study is limited by the small sample size and short- term outcomes, but improvements were shown in the context of prior long-term deterioration. The before- after design and lack of a control group mean that this ...
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A randomised controlled trial of intravenous zoledronic acid in malignant pleural disease: A proof of principle pilot study
... This study was designed as a proof-of-principle pilot study and hence has a number of limi- tations. We excluded patients receiving other cancer treatments and given the frail nature of this population, ...
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The NOTHING ELSE Brand: A Case Study
... A major limitation of this case study is the small number of participants who completed the questionnaires. As a proof of principle this ongoing project has a number of strengths. The AUT University has a ...
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Verification of an Automated, Digital Dispensing Platform for At Will Broth Microdilution Based Antimicrobial Susceptibility Testing
... As proof of principle, we verified the performance characteristics of this combined digital dispensing method (DDM) by testing representative clinical isolates of the Enterobacteriaceae for susceptibility ...
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A new diagnostic approach for the identification of patients with neurodegenerative cognitive complaints
... this proof-of-principle study, we demonstrate that purely acoustic features, extracted from recordings of patients’ answers to a neurologist’s questions in a specialist memory clinic can support the initial ...
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Integrality and rigidity for postcritically finite polynomials
... Proof: Over an algebraically closed field, an algebraic set which is bounded relative to a nontrivial absolute value is necessarily zero-dimensional, hence finite, since any curve projects to a Zariski dense ...
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Kreisel's theory of constructions, the Kreisel Goodman paradox, and the second clause
... the proof relation appears to have a strong pre-theoretical basis in the intuitionists’ desire to view the BHK clauses as providing a decidable proof condition for formulas of arbitrary logical ...
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Moderate deviations and central limit theorem for positive diffusions
... This type of moderate deviations for stochastic (partial) differential equations with Lipschitz coefficients has been studied; see [, ] and so on. Wang and Zhang [] estab- lished the moderate deviation ...
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The use of everolimus in the treatment of neurocognitive problems in tuberous sclerosis (TRON): study protocol for a randomised controlled trial
... This is a single-centre, two-arm, individually rando- mised, phase II, double-blind, placebo-controlled trial of everolimus versus placebo (allocation ratio of 2:1, re- spectively) in the treatment of neurocognitive ...
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Proof lengths for instances of the Paris–Harrington principle
... “slow proof” in Peano Arithmetic, deduced from the slow consistency statement introduced by Sy-David Friedman, Rathjen and Weiermann in ...in proof size. This generates an interplay between proof ...
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RETRACTED: The Riemann Hypothesis Holds True: A Rigorous Proof with Mean Formula and Extremum Principle
... Is it true? In 1986 the first 1.5 billion nontrivial zeros of ζ ( ) s (arranged by increasing positive imaginary part) had been checked in [2], and the result showed that they are simple and possess real part Re ( ) s = ...
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On maximal inequalities via comparison principle
... In the next section, using a comparison principle, a two-sided explicit estimate of the maximal solution y → g ∗ (y) of () is given based on the maximal and minimal solutions of (). Our main emphasis is on the ...
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