Prostaglandin E2 (PGE2)
BERBERINE CHLORIDE INDUCED APOPTOSIS IN HEPG2 CANCER CELL LINE VIA PPAR GAMMA ACTIVATION AND COX2 INHIBITION BY REGULATING PROSTAGLANDIN E2 (PGE2) SIGNALLING PATHWAY
... Berberine canonically has the potential to modulate Wnt/β-catenin pathway leading to cell death in cancer cell lines treated. Berberine induced apoptosis in prostate cancer cells by direct activation of AMPK (5' ...
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The role of prostaglandin E2 receptors in the pathogenesis of rheumatoid arthritis
... that prostaglandin E2 (PGE2) contributes to the patho- genesis of RA, and nonsteroidal anti-inflammatory drugs, inhibitors of the synthesis of PGE2 and other prostanoids, continue to be used ...
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Prostaglandin E2 induces Skin Aging via E-prostanoid 1 in Normal Human Dermal Fibroblasts
... function. Prostaglandin E2 (PGE2), a lipid-derived signaling molecule produced from arachidonic acid by cyclo-oxygenase, inhibits collagen production and induces matrix metallopeptidase 1 (MMP1) ...
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A Comparative study of Extra-Amniotic Saline Infusion (EASI), Foley’s Catheter and Prostaglandin E2(PGE2) gel for Pre-Induction Cervical Ripening
... Results: Majority of the cases was primigravida (67.3%) and the most common indication of induction was postdated pregnancy (72%). The mean time for induction to cervical ripening interval was shorter in Foley’s catheter ...
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Inhibition of lipopolysaccharide induced nitric oxide and prostaglandin E2 production by chloroform fraction of Cudrania tricuspidata in RAW 264 7 macrophages
... din E2 (PGE2) are generated by the inducible isoforms of NO synthase (NOS) and cyclooxygenase-2 (COX-2) ...and PGE2 is an important therapeutic target in the development of anti-inflammatory ...
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Butyrate attenuates lipolysis in adipocytes co-cultured with macrophages through non-prostaglandin E2–mediated and prostaglandin E2–mediated pathways
... of PGE2 into the medium and on lipolysis in ...increased PGE2 release into the medium, compared with cells cultured ...extent, PGE2) suppressed FFAs and free glycerol ...a prostaglandin E ...
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Role of prostaglandin E2 in the pathogenesis of pulmonary fibrosis
... of PGE2 (McAnulty et a l, ...f PGE2 in response to TGF-pi (section ...synthesize PGE2 in response to TGF-p; by fibroblasts from groups II and III correlated with a loss o f their anti-proliferative ...
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Prostaglandin E2 inhibits renal collecting duct Na+ absorption by activating the EP1 receptor
... PGE2 exerts potent diuretic and natriuretic effects on the kidney. This action is mediated in part by direct inhibition of collecting duct Na+ absorption via a Ca++-coupled mechanism. These studies examine the ...
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Interactions among prostaglandin E2, antidiuretic hormone, and cyclic adenosine monophosphate in modulating Cl absorption in single mouse medullary thick ascending limbs of Henle
... the PGE2-mediated reductions in the ADH- dependent moiety of Ve in the mouse mTALH; that PGE2 had no effect on cyclic AMP- stimulated increments in Ve in the mouse mTALH; and that PGE2 had no effect ...
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Role of endogenous prostaglandin E2 in erythropoietin production and dome formation by human renal carcinoma cells in culture
... revealed PGE2 to be the major metabolite of 14C-AA produced by the cultured cells throughout the 30 d of ...of PGE2 and Ep in the incubated media were measured via ...radioimmunoassay. PGE2 levels in ...
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Macrophage-mediated response to hypoxia in disease
... Abbreviations: veGF, vascular endothelial growth factor; MMP, matrix metalloproteinase; PGe2, prostaglandin e2; HGF, hepatocyte growth factor; iL10, interleukin 10; ORP150, oxygen-regul[r] ...
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Lipid mediators in plasma of autism spectrum disorders
... Prostaglandin E2 (PGE2) is a compound derived from membrane phospholipids and an important mediator of synaptic plasticity, pain response, sleep/ awake cycle and is believed to be associated with ...
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Genetic variation in prostaglandin E2 synthesis and signaling, prostaglandin dehydrogenase, and the risk of colorectal adenoma.
... b Number of principal components that explain ≥80% of the variance in polyp risk c Likelihood ratio test comparing a model with principle components + age and sex to a model containi[r] ...
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Genetic variation in prostaglandin E2 synthesis and signaling, prostaglandin dehydrogenase, and the risk of colorectal adenoma.
... significant association for a tagSNP in EP2 and in EP4, but no other associations between tagSNPs in PGES or PGDH and risk of colorectal adenomas. Further, we observed several statistically significant or marginally ...
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Macrophage migration inhibitory factor enhances lipopolysaccharide induced fibroblast proliferation by inducing toll like receptor 4
... assessing prostaglandin E2 (PGE2) secretion by fibroblasts challenged by lipopolysaccharide (LPS) and macrophage migration inhibitory factor (MIF), we fortuitously found LPS alone stimulates ...
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Supplement of 5 hydroxytryptophan before induction suppresses inflammation and collagen induced arthritis
... 5 Effects of 5-hydroxytryptophan 5-HTP on the expression of cyclooxygenase-2 COX-2 and prostaglandin E2 PGE2 in activated splenocytes and mice with collagen-induced arthritis CIA.. a mRN[r] ...
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Abnormal increase in urinary aquaporin-2 excretion in response to hypertonic saline in essential hypertension
... Methods: We measured urinary excretion of AQP2 and ENaC b -subunit corrected for creatinine (u-AQP2CR, u- ENaC b -CR), prostaglandin E2 (u-PGE2) and cyclic AMP (u-cAMP), fractional sodiu[r] ...
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Airway response to acute mechanical stress in a human bronchial model of stretch
... Effect of stretch 5 minutes, 2.5 × basal tone on the production of leukotriene E4 LTE4, prostaglandin screening PG, and prostaglandin E2 PGE2 in an organ bath assessed by ELISA during th[r] ...
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Reproductive failure and reduced blood pressure in mice lacking the EP2 prostaglandin E2 receptor
... Prostaglandins (PGs) are bioactive lipids that modulate a broad spectrum of biologic processes includ- ing reproduction and circulatory homeostasis. Although reproductive functions of mammals are influ- enced by PGs at ...
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The subtype 2 (AT2) angiotensin receptor regulates renal cyclic guanosine 3', 5' monophosphate and AT1 receptor mediated prostaglandin E2 production in conscious rats
... ade could increase the cGMP-inhibitable isoform of cAMP phosphodiestrase (PDE III), resulting in diminished renal cAMP levels (21). The latter would promote prostaglandin formation, as cAMP has been shown to ...
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