prostaglandin synthesis
Attenuation of Angiotensin II and III induced Aldosterone Release by Prostaglandin Synthesis Inhibitors
... two prostaglandin synthesis inhibitors, indomethacin and meclofenamate, on angiotensin II (AII)- and III (AIII)-induced aldosterone release was studied in normal and sodium-depleted conscious rats and in ...
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Inhibition of prostaglandin synthesis after metabolism of menadione by cultured porcine endothelial cells
... prostaglandin synthesis. Addition of 1-20 microM menadione caused a dose- and time- dependent inhibition of stimulated prostaglandin synthesis with an IC50 of 5 microM at 15 min. ...
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Renal prostaglandin synthesis in the spontaneously hypertensive rat
... renal prostaglandin synthesis by utilizing a spontaneously hypertensive rat ...of prostaglandin E2, prostaglandin F2alpha, and prostaglandin A2-like products was measured in vitro with ...
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Effects of DNA and prostaglandin synthesis inhibitors on the stimulation of bone resorption by epidermal growth factor in fetal rat long bone cultures
... of prostaglandin synthesis since flufenamic acid had similar ...DNA synthesis since APC, in the absence of cyclooxygenase inhibitors, completely blocked EGF-mediated resorption without significantly ...
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Regulation of vascular prostaglandin synthesis by metabolites of arachidonic acid in perfused rabbit aorta
... cyclooxygenase and prostacyclin synthetase by measuring PGI2 and PGE2 production rates and by infusing cyclic endoperoxides. Our results indicate preferential inactivation of cyclooxygenase during arachidonate ...
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The effect of inhibition of prostaglandin synthesis on urinary sodium excretion in the conscious dog
... that prostaglandin inhibition in the conscious dog is associated with a natriuresis without a change in urinary volume or potassium excretion during water ...
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Role of local prostaglandin synthesis in the modulation of proliferative activity of rat colonic epithelium
... local prostaglandin (PG) synthesis in the modulation of the proliferative activity of colonic epithelium was examined in rat ...(i) prostaglandin E (PGE), the dominant PG product of colon segment ...
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Mesenchyme epithelial interactions in human endometrium Prostaglandin synthesis in separated cell types
... Radiolabeled prostaglandin E2 and, to a lesser extent, prostaglandin F2 alpha and metabolites of these prostaglandins, were formed principally in stromal ...
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Human platelet derived growth factor stimulates prostaglandin synthesis by activation and by rapid de novo synthesis of cyclooxygenase
... stimulated prostaglandin (PG) E2 synthesis in the cell cycle of Swiss 3T3 cells at two distinct time intervals, with a first plateau within 10 min and a second plateau within 2-4 h after addition of ...
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Modulation of keratinocyte proliferation in vitro by endogenous prostaglandin synthesis
... synthesized prostaglandin (PG)E2 PGD2, PGF2 alpha, and small quantities of 6-keto-F1 ...increased synthesis of PGE2 was accompanied by a fourfold increase in the rate of ...PGE2 synthesis was ...
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Abnormal Platelet and Vascular Prostaglandin Synthesis in an Infant with Hemolytic Uremic Syndrome
... Normalization of PGI2 regenerative activity and the platelet count occurred initially following plasma infusion. Thrombocytopenia recurred, however, and subse-[r] ...
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Increased renal sodium absorption by inhibition of prostaglandin synthesis during fasting in healthy man. A possible role of the epithelial sodium channels
... Methods: The effect of ibuprofen, 600 mg thrice daily, was measured during fasting in a randomized, placebo- controlled, double-blinded crossover study of 17 healthy humans. The subjects received a standardized diet on ...
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AM404, paracetamol metabolite, prevents prostaglandin synthesis in activated microglia by inhibiting COX activity
... Some studies have demonstrated the effect of AM404 in modulating inflammation and oxidative stress. Its effects on reducing oxidative stress have been associated with the presence of a phenolic group in its structure ...
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Genetic variation in prostaglandin E2 synthesis and signaling, prostaglandin dehydrogenase, and the risk of colorectal adenoma.
... significant association for a tagSNP in EP2 and in EP4, but no other associations between tagSNPs in PGES or PGDH and risk of colorectal adenomas. Further, we observed several statistically significant or marginally ...
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GASTROPROTECTIVE NSAIDs
... of prostaglandin synthesis was unlikely to be the sole mechanism responsible for gastric injuries induced by NSAIDs induced gastric ulceration is well studied where it reported that the excessive generation ...
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Episode-Specific Differential Gene Expression of Peripheral Blood Mononuclear Cells in Rapid Cycling Supports Novel Treatment Approaches
... Prostaglandin synthesis plays a pivotal role in metabolic homeostasis, sleep regulation, adipogenesis, allergic re- sponse, and inflammation ...altered prostaglandin metabolism may lead to mood ...
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Crypt stem cell survival in the mouse intestinal epithelium is regulated by prostaglandins synthesized through cyclooxygenase 1
... inhibiting prostaglandin synthesis either before or after irradiation were not ...intestinal prostaglandin levels) crypt survival was not ...increasing prostaglandin levels above those present ...
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Urinary Potassium Excretion in the Critically III Neonate
... Urinary losses of potassium may be augmented to exaggerate further the negative potassium balance when prostaglandin synthesis is increased, when urine flow rate is sustained at a high r[r] ...
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Studies on the Anti-Inflammatory, Analgesic and Antipyretic Properties of Pavonia Zeylanica
... to prostaglandin synthesis inhibition, as described for the anti-inflammatory mechanism of non- steroidal anti-inflammatory drugs in the inhibition of inflammatory process induced by ...
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Bacterial lipopolysaccharide mediated fetal death Production of a newly recognized form of inducible cyclooxygenase (COX 2) in murine decidua in response to lipopolysaccharide
... To test the hypothesis that the induction of COX, specifically the highly inducible isotype COX-2, might increase uterine prostaglandin synthesis, we characterized decidual protein and m[r] ...
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