protease-activated receptor-1
Protease-activated receptor-1 (PAR1) promotes epithelial-endothelial transition through Twist1 in hepatocellular carcinoma
... transcription factor-Twist1 can promote the transcription of vascular endothelial (VE)-cadherin and induce the formation of VM channels [10]. However, the upstream signal of Twist1 is unclear. Epithelial–endothelial ...
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Ligation of protease activated receptor 1 enhances αv β6 integrin–dependent TGF β activation and promotes acute lung injury
... Activation of latent TGF-b by the a v b 6 integrin is a critical step in the development of acute lung injury. However, the mechanism by which a v b 6 -mediated TGF-b activation is regulated has not been identified. We ...
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Protease Activated Receptor-1 Deficiency Diminishes Bleomycin-Induced Skin Fibrosis
... Accumulating evidence shows that protease-activated receptor-1 (PAR-1) plays an important role in the development of fibro- sis, including lung fibrosis. However, whether PAR-1 ...
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Activation of protease activated receptor 1 increases the excitability of the dentate granule neurons of hippocampus
... Protease activated receptor-1 (PAR1) is expressed in multiple cell types in the CNS, with the most prominent expression in glial ...NMDA receptor-mediated component of ...
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Protease activated receptor 1-induced glutamate release in cultured astrocytes is mediated by Bestrophin-1 channel but not by vesicular exocytosis
... we activated endogenous GPCRs by appli- cation of TFLLR [27] a selective peptide agonist of the protease activated receptor 1 ...
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Protease activated receptor-1 regulates macrophage-mediated cellular senescence: a risk for idiopathic pulmonary fibrosis
... Idiopathic pulmonary fibrosis (IPF) is a destructive disease in part resulting from premature or mature cellular aging. Protease-activated receptor-1 (PAR-1) recently emerged as a ...
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Protease-activated receptor-1 activation by granzyme B causes neurotoxicity that is augmented by interleukin-1β
... The total number of cells and immunolabeled cells were counted manually in a minimum of ten fields from within and immediately around subcortical white matter (healthy or containing a lesion) and the adjacent cerebral ...
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Expression of Protease-Activated Receptor 1 and 2 and Anti-Tubulogenic Activity of Protease-Activated Receptor 1 in Human Endothelial Colony-Forming Cells
... the culture medium (12% in our study versus 2–5% in the other studies [17–19]); and 2) extracellular matrix coating of the culture vessels (collagen in our study versus gelatin [17,19] or fibronectin [18] in the other ...
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Unmet needs in the management of acute myocardial infarction: role of novel protease-activated receptor-1 antagonist vorapaxar
... Abstract: Platelet activation with subsequent aggregation is a complex process leading to thrombus formation, which remains a key component for atherothrombotic manifestations, in particular myocardial infarction. ...
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Clathrin-dependent internalization of protease-activated receptor-1: regulation by ubiquitination and epsin
... The internalization of cargo through clathrin-coated pits is a highly regulated and dynamic process occurring within the 20-90 second lifetime of a clathrin bud. Endocytosis of different types of cargo can be saturated ...
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Tissue factor in tumor microenvironment: a systematic review
... factor receptor (EGFR) and its mutant form EGFRvIII also regulate the expression of flTF, FVII, protease-activated receptor 1 (PAR1) and PAR2 ...factor 1 alpha (HIF-1α), and ...
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Lipopolysaccharide pretreatment increases protease-activated receptor-2 expression and monocyte chemoattractant protein-1 secretion in vascular endothelial cells
... Unless stated otherwise, trypsin, purified LPS (obtained through phenol extraction) from Escherichia coli (serotype O26:B6), salts, buffers, and all other chemicals of reagent grade were purchased from Sigma-Aldrich (St. ...
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Protease Activated Receptor 4 as a Novel Modulator of Regulatory T Cell Function
... thrombin receptor which was less sensitive to thrombin-mediated activation than PAR1 ...serine protease-1, an initiator of the complement lectin pathway (56, ...being activated in our ...
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The protease activated receptor 2 agonist induces gastric mucus secretion and mucosal cytoprotection
... Protease-activated receptor-2 (PAR-2) (1), a G pro- tein–coupled receptor, is activated by proteolytic unmasking of the N-terminal extracellular tethered ligand that presumably ...
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Modulation of protease-activated receptor expression by Porphyromonas gingivalis in human gingival epithelial cells
... Within 1 h, tissue was prepared to obtain epithe- lial ...× 1 mm), treated with a solution of 25 % dispase II (Sigma–Aldrich, St Louis, MO, USA) and incubated for 18 h at 4 ...
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Protease-activated receptor 4 variant p.Tyr157Cys reduces platelet functional responses and alters receptor trafficking
... It is significant that Y157C was associated with gastrointestinal bleeding only during aspirin treatment in the index case Y157C.1, and that the pedigree members with Y157C had no abnormal bleeding. This suggests ...
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Thrombin induces heme oxygenase 1 expression in human synovial fibroblasts through protease activated receptor signaling pathways
... as protease-activated receptors ...thrombin activated the PAR1/PAR3 receptor, PKC δ , c-Src, and Nrf2 pathways, leading to the upregulation of HO-1 ...
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Thrombin promotes fibronectin secretion by bone marrow mesenchymal stem cells via the protease-activated receptor mediated signalling pathways
... Figure 3 Thrombin pretreatment promotes the adhesion of MSCs to the culture plastic. A: Aliquots (2 × 10 4 /100 μ l) of MSCs or MSCs were pre-treated with thrombin (4 U/ml) for 24 h were seeded into a 96-well culture ...
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Protease-activated receptor-2 : a novel pathogenic pathway in a murine model of osteoarthritis
... operated mice (Fig 1d), PAR-2 +/+ mice showed cartilage damage and increased subchondral bone formation (Fig 1e) whereas such changes were minimal in PAR-2 -/- mice (Fig 1f). Such differences could not be attributed to ...
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The role of protease-activated receptor-2 on pulmonary neutrophils in the innate immune response to cockroach allergen
... Following PBS or allergen exposure, lungs were lavaged with Hanks balanced salt solution without calcium or magnesium. The lavage fluid was centrifuged (300 g for 10 min at 4°C), and the supernatant was removed. The cell ...
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