protease activated receptor (1–4)
Protease-activated receptor-2 : a novel pathogenic pathway in a murine model of osteoarthritis
... globally 1 with radiological evidence of OA in approximately 80% of the population aged over ...target. Protease-activated receptor-2 (PAR-2) is a G-protein coupled receptor whose ...
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Protease activated receptor-1 regulates macrophage-mediated cellular senescence: a risk for idiopathic pulmonary fibrosis
... Idiopathic pulmonary fibrosis (IPF) is a destructive disease in part resulting from premature or mature cellular aging. Protease-activated receptor-1 (PAR-1) recently emerged as a ...
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Activation of protease-activated receptor 2 reduces glioblastoma cell apoptosis
... Protease-activated receptor (PAR) 2 is a member of the large family of 7-transmembrane receptors that cou- ple to guanosine-nucleotide-binding ...be activated by proteolytic cleavage of its ...
6
Activation of protease activated receptor 1 increases the excitability of the dentate granule neurons of hippocampus
... Protease activated receptor-1 (PAR1) is expressed in multiple cell types in the CNS, with the most prominent expression in glial ...NMDA receptor-mediated component of ...
12
The protease activated receptor 2 agonist induces gastric mucus secretion and mucosal cytoprotection
... Protease-activated receptor-2 (PAR-2) (1), a G pro- tein–coupled receptor, is activated by proteolytic unmasking of the N-terminal extracellular tethered ligand that presumably ...
9
Protease-activated receptor-1 (PAR1) promotes epithelial-endothelial transition through Twist1 in hepatocellular carcinoma
... transcription factor-Twist1 can promote the transcription of vascular endothelial (VE)-cadherin and induce the formation of VM channels [10]. However, the upstream signal of Twist1 is unclear. Epithelial–endothelial ...
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Protease Activated Receptor-1 Deficiency Diminishes Bleomycin-Induced Skin Fibrosis
... Accumulating evidence shows that protease-activated receptor-1 (PAR-1) plays an important role in the development of fibro- sis, including lung fibrosis. However, whether PAR-1 ...
7
Protease-activated receptor-1 activation by granzyme B causes neurotoxicity that is augmented by interleukin-1β
... receptors activated by cytotoxic substances released during inflamma- ...The protease-activated receptor (PAR) is a G- protein coupled receptor whose unique activation requires cleavage ...
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Expression of Protease-Activated Receptor 1 and 2 and Anti-Tubulogenic Activity of Protease-Activated Receptor 1 in Human Endothelial Colony-Forming Cells
... of protease-activated receptor (PAR) 1 and 2 amongst the surface proteins expressed in ...(ERK) 1 and 2, which become activated and phosphorylated in response to selective PAR1- ...
10
Protease activated receptor 1-induced glutamate release in cultured astrocytes is mediated by Bestrophin-1 channel but not by vesicular exocytosis
... we activated endogenous GPCRs by appli- cation of TFLLR [27] a selective peptide agonist of the protease activated receptor 1 ...
9
Protease Activated Receptor 4 as a Novel Modulator of Regulatory T Cell Function
... thrombin receptor which was less sensitive to thrombin-mediated activation than PAR1 ...serine protease-1, an initiator of the complement lectin pathway (56, ...being activated in our ...
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Mucosal sensitization to German cockroach involves protease-activated receptor-2
... Interestingly protease-depleted GC frass bound to alum and administered by intraperitoneal injection decreased total serum IgE ...to protease activity or may be a non-specific ...
10
Unmet needs in the management of acute myocardial infarction: role of novel protease-activated receptor-1 antagonist vorapaxar
... loading doses of vorapaxar (10, 20, and 40 mg) were com- pared with matched placebo (3:1 ratio) on top of standard antiplatelet-treatment regimens, which included many patients on standard dual-antiplatelet ...
12
Thrombin promotes fibronectin secretion by bone marrow mesenchymal stem cells via the protease-activated receptor mediated signalling pathways
... 10 4 /100 μ l) of MSCs or MSCs were pre-treated with thrombin (4 U/ml) for 24 h were seeded into a 96-well culture plate for spontaneous adhesion for 1 h (a and b), the non-adherent cells was then ...
11
Lipopolysaccharide pretreatment increases protease-activated receptor-2 expression and monocyte chemoattractant protein-1 secretion in vascular endothelial cells
... Unless stated otherwise, trypsin, purified LPS (obtained through phenol extraction) from Escherichia coli (serotype O26:B6), salts, buffers, and all other chemicals of reagent grade were purchased from Sigma-Aldrich (St. ...
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Modulation of protease-activated receptor expression by Porphyromonas gingivalis in human gingival epithelial cells
... P. gingivalis supernatants were diluted in cell culture medium and their concentration expressed as the total bacterial protein (mg/ml) present in the cell cultures. The protein concentration was determined with a BCA ...
8
Thrombin induces heme oxygenase 1 expression in human synovial fibroblasts through protease activated receptor signaling pathways
... Several binding sites exist for a number of transcrip- tion factors, including ARE in the 5’ promoter region of the HO-1 gene [37]. The results of this study show that Nrf2 activation contributes to ...
10
Essential role of platelet activation via protease activated receptor 4 in tissue factor initiated inflammation
... Injection of sTF into the footpad of C57Bl/6 mice provoked an acute inflammatory response. Edema and erythema developed rapidly following injection (Figure 1b). The inflammatory response was quantified by measuring the ...
8
Protease-activated receptor 4 variant p.Tyr157Cys reduces platelet functional responses and alters receptor trafficking
... It is significant that Y157C was associated with gastrointestinal bleeding only during aspirin treatment in the index case Y157C.1, and that the pedigree members with Y157C had no abnormal bleeding. This suggests ...
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Protease and Protease Activated Receptor 2 Signaling in the Pathogenesis of Atopic Dermatitis
... serine protease inhibitors are present in the skin, and regulate proteolytic activity in order to prevent excessive serine protease cascade, while also maintaining permeability barrier ...serine ...
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