Protease-activated receptor 2
Activation of protease-activated receptor 2 reduces glioblastoma cell apoptosis
... Background: The pathogenesis of glioma is unclear. The disturbance of the apoptosis process plays a critical role in glioma growth. Factors regulating the apoptosis process are to be further understood. This study aims ...
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Mast cells and mast cell tryptase enhance migration of human lung fibroblasts through protease-activated receptor 2
... ligand 2; cDNA: Complementary Deoxyribonucleic acid; CM: Conditioned medium; COPD: Chronic obstructive pulmonary disease; DMEM: Dulbecco ’ s modified eagle medium; ECM: Extracellular matrix; ELISA: Enzyme-linked ...
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The protease activated receptor 2 agonist induces gastric mucus secretion and mucosal cytoprotection
... Protease-activated receptor-2 (PAR-2), a receptor activated by trypsin/tryptase, modulates smooth muscle tone and exocrine secretion in the salivary glands and ...
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Mast cell tryptase stimulates myoblast proliferation; a mechanism relying on protease activated receptor 2 and cyclooxygenase 2
... of protease-activated receptor-2 (PAR-2) and a subse- quent increase in COX-2 expression, a finding adding further importance to the role of COX-2 as an important actor ...
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Pharmacological Targeting of Protease-Activated Receptor 2 Affords Protection from Bleomycin-Induced Pulmonary Fibrosis
... that protease-activated receptor 2 (PAR-2) contributes to fibrosis, its importance in pulmonary fibrosis is under ...PAR- 2 may be a promising therapeutic strategy for treating ...
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Increased Expression of Cathelicidin by Direct Activation of Protease Activated Receptor 2: Possible Implications on the Pathogenesis of Rosacea
... and protease-activated receptor 2 (PAR-2) is there- fore of interest, as PAR-2, expressed principally in keratinocytes, regulates pro- inflammatory cytokine expression in the ...
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Role of protease activated receptor 2 on cell death and DNA fragmentation in Helicobacter pylori infected gastric epithelial cells
... carcinoma. Protease-activated receptor-2 (PAR-2), which is activated by trypsin, induced the activation of mitogen- activated protein kinases (MAPK), cell proliferation ...
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Signal regulation of protease-activated receptor-2 and structural determinants of G[alpha]q-dependent activation and deactivation of phospholipase C-[beta]
... Protease-activated receptor 2 (PAR2) is a member of the protease-activated G protein-coupled receptor (GPCR) family that includes PAR1, PAR3 and PAR4 (Arora et ...
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Activated Factor X signaling via protease activated receptor 2 suppresses pro inflammatory cytokine prodution from LPS stimulated myeloid cells
... a protease crucial for blood coagulation, also induces protease-activated, receptor-dependent cell ...Toll-like receptor activation is not ...of protease-activated ...
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Protease-activated receptor-2 : a novel pathogenic pathway in a murine model of osteoarthritis
... 65. 2 OA is characterised by cartilage degradation and increased subchondral bone formation ...target. Protease-activated receptor-2 (PAR-2) is a G-protein coupled ...
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Protease-activated receptor 2 : are common functions in glial and immune cells linked to inflammation-related CNS disorders?
... Ca 2+ [100], is mediated via the CXCR2 chemokine receptor as the selective antagonist, reparixin blocks the PAR2-mediated effects ...glutamate receptor antagonist, LY341495, inhibited the ...
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Protease and Protease Activated Receptor 2 Signaling in the Pathogenesis of Atopic Dermatitis
... activating protease-activated receptors (PARs), the G-protein-coupled ...and protease inhibitors associated with genetic defects in the protease/protease inhibitor encoding genes, ...
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Lipopolysaccharide pretreatment increases protease-activated receptor-2 expression and monocyte chemoattractant protein-1 secretion in vascular endothelial cells
... Unless stated otherwise, trypsin, purified LPS (obtained through phenol extraction) from Escherichia coli (serotype O26:B6), salts, buffers, and all other chemicals of reagent grade were purchased from Sigma-Aldrich (St. ...
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Therapeutic effect of protease-activated receptor 2 agonist SLIGRL-NH<sub>2</sub> on loperamide-induced Sprague-Dawley rat constipation model and the related mechanism
... SLIGRL-NH 2 on the feeding and excretion behaviors of the constipated ...SLIGRL-NH 2 and prucalopride treatment increased the food and water intake of the constipated rats (Table ...SLIGRL-NH 2 on ...
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Cathepsin S acts via protease-activated receptor 2 to activate sensory neurons and induce itch-like behaviour
... At least 4 weeks after the blast-TBI, non-recovery surgical proce- dures were used to prepare for extracellular recordings. Rats were in- itially anesthetized (60 mg/kg ketamine and 7.5 mg/kg xylazine given IP) to insert ...
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Signaling Pathways in Airway Mucin Secretion: Roles of Protease-Activated Receptor-2, MARCKS, and Related Chaperone and Cytoskeletal Proteins.
... serine protease, is a potent endogenous mucin secretagogue (50) that also may cause goblet cell metaplasia and increased production of mucin (46, ...not activated by this elastase (206) and not by ...
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Mucosal sensitization to German cockroach involves protease-activated receptor-2
... that protease activity in aller- gens may alter airway epithelial integrity by increasing epithelial permeability ...of protease-activated receptors (PARs). PARs (-1, -2, -3, - 4) are a family ...
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Design, Synthesis, and Evaluation of Novel Protease-Activated Receptor 2 (PAR2)-Targeting Imaging Agents for Cancer
... to 2 through a calcium assay, but later they were reported to have a reduced affinity for PAR2 through a competitive binding assay, likely due to the absence of strong hydrogen bond(s) or electrostatic ...
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Conserved Structure and Adjacent Location of the Thrombin Receptor and Protease-Activated Receptor 2 Genes Define a Protease-Activated Receptor Gene Cluster
... Analysis of A phage and cosmid genomic clones revealed a two-exon structure for the mouse and human thrombin receptor genes.. The first exon.[r] ...
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The role of protease-activated receptor-2 on pulmonary neutrophils in the innate immune response to cockroach allergen
... activate protease-activated receptor (PAR)-2 on a variety of cells including human bronchial epithelial cells [8] mouse tracheal epithelial cells [9] and al- veolar macrophages ...is ...
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