protease-activated receptor-2 (PAR-2)
Role of protease activated receptor 2 on cell death and DNA fragmentation in Helicobacter pylori infected gastric epithelial cells
... carcinoma. Protease-activated receptor-2 (PAR-2), which is activated by trypsin, induced the activation of mitogen- activated protein kinases (MAPK), cell ...
7
Pharmacological Targeting of Protease-Activated Receptor 2 Affords Protection from Bleomycin-Induced Pulmonary Fibrosis
... that protease-activated receptor 2 (PAR-2) contributes to fibrosis, its importance in pulmonary fibrosis is under ...whether PAR-2 deficiency persistently reduces ...
8
Protease-activated receptor-2 : a novel pathogenic pathway in a murine model of osteoarthritis
... 65. 2 OA is characterised by cartilage degradation and increased subchondral bone formation ...target. Protease-activated receptor-2 (PAR-2) is a G-protein coupled ...
16
Increased Expression of Cathelicidin by Direct Activation of Protease Activated Receptor 2: Possible Implications on the Pathogenesis of Rosacea
... and protease-activated receptor 2 (PAR-2) is there- fore of interest, as PAR-2, expressed principally in keratinocytes, regulates pro- inflammatory cytokine ...
8
Mast cell tryptase stimulates myoblast proliferation; a mechanism relying on protease activated receptor 2 and cyclooxygenase 2
... of protease-activated receptor-2 (PAR-2) and a subse- quent increase in COX-2 expression, a finding adding further importance to the role of COX-2 as an important ...
9
The protease activated receptor 2 agonist induces gastric mucus secretion and mucosal cytoprotection
... Protease-activated receptor-2 (PAR-2), a receptor activated by trypsin/tryptase, modulates smooth muscle tone and exocrine secretion in the salivary glands and ...
9
Activated Factor X signaling via protease activated receptor 2 suppresses pro inflammatory cytokine prodution from LPS stimulated myeloid cells
... a protease crucial for blood coagulation, also induces protease-activated, receptor-dependent cell ...Toll-like receptor activation is not ...of protease-activated ...
9
Activation of protease-activated receptor 2 reduces glioblastoma cell apoptosis
... Background: The pathogenesis of glioma is unclear. The disturbance of the apoptosis process plays a critical role in glioma growth. Factors regulating the apoptosis process are to be further understood. This study aims ...
6
Mast cells and mast cell tryptase enhance migration of human lung fibroblasts through protease-activated receptor 2
... ligand 2; cDNA: Complementary Deoxyribonucleic acid; CM: Conditioned medium; COPD: Chronic obstructive pulmonary disease; DMEM: Dulbecco ’ s modified eagle medium; ECM: Extracellular matrix; ELISA: Enzyme-linked ...
13
Effect of tryptase on mouse brain microvascular endothelial cells via protease-activated receptor 2
... from activated MC granules and its proteo- lytic activities release matrix-associated growth factors or degrade extracellular matrix components associated with a critical step in the early stages of angiogenesis ...
9
The role of protease-activated receptor-2 on pulmonary neutrophils in the innate immune response to cockroach allergen
... expressed PAR-2 and if these levels were regulated by allergen exposure, we performed a single intratracheal instillation of GC frass into naïve mice and harvested the lungs 20 h ...for PAR-2 ...
9
The activation of lung fibroblasts by human mast cell tryptase: A role for protease activated receptor-2 (PAR-2)
... hBRIE380, PAR-2 activating peptides caused increases in ERK-1 and -2 (DeFea et a l, ...following PAR-2 stimulation, ERK-1 stimulated cell activation was dependent on the receptor ...
349
Protease and Protease Activated Receptor 2 Signaling in the Pathogenesis of Atopic Dermatitis
... activating protease-activated receptors (PARs), the G-protein-coupled ...functional PAR-2 on human skin and its role in inflammation, pruritus, and skin barrier homeostasis have been ...and ...
15
Protease-activated receptor 2 activation of myeloid dendritic cells regulates allergic airway inflammation
... in PAR-2 -/- mice, a dramatic impact on neutrophil recruitment was not observed in mice sensitized with GC frass-pulsed PAR-2 -/- BMDCs (~20% ...both PAR-2 -/- and mice ...
14
Signaling Pathways in Airway Mucin Secretion: Roles of Protease-Activated Receptor-2, MARCKS, and Related Chaperone and Cytoskeletal Proteins.
... serine protease, is a potent endogenous mucin secretagogue (50) that also may cause goblet cell metaplasia and increased production of mucin (46, ...(204). PAR-2 activation also enhances neutrophil ...
145
Mucosal sensitization to German cockroach involves protease-activated receptor-2
... of PAR-2 in mediating experimen- tally-induced allergic airway inflammation, we used com- mercially available PAR-2-deficient mice which were on a C57Bl/6 ...the PAR-2-deficient ...
10
Protease-activated receptor 2 : are common functions in glial and immune cells linked to inflammation-related CNS disorders?
... Ca 2+ [100], is mediated via the CXCR2 chemokine receptor as the selective antagonist, reparixin blocks the PAR2-mediated effects ...glutamate receptor antagonist, LY341495, inhibited the ...
31
Cathepsin S acts via protease-activated receptor 2 to activate sensory neurons and induce itch-like behaviour
... We recorded responses of single units to a series of stimuli applied with mechanical forces that spanned the innocuous and noxious range. We stimulated vibrissae with innocuous air puffs delivered with a Picospritzer, as ...
12
Investigation of Possible Role of the PAR-2 Receptor in Intestinal Inflammation
... of PAR-2 (protease activated receptor-2) receptor in gut is pro-inflammatory and thus appears as a new potential therapeutic target for inflammatory bowel disease ...
5
Design, Synthesis, and Evaluation of Novel Protease-Activated Receptor 2 (PAR2)-Targeting Imaging Agents for Cancer
... to 2 through a calcium assay, but later they were reported to have a reduced affinity for PAR2 through a competitive binding assay, likely due to the absence of strong hydrogen bond(s) or electrostatic ...
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