protease (proteinase)-activated receptor
Expression of Protease-Activated Receptor 1 and 2 and Anti-Tubulogenic Activity of Protease-Activated Receptor 1 in Human Endothelial Colony-Forming Cells
... of protease-activated receptor (PAR) 1 and 2 amongst the surface proteins expressed in ...become activated and phosphorylated in response to selective PAR1- or PAR2-activating ...
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Protease Activated Receptor-1 Deficiency Diminishes Bleomycin-Induced Skin Fibrosis
... Accumulating evidence shows that protease-activated receptor-1 (PAR-1) plays an important role in the development of fibro- sis, including lung fibrosis. However, whether PAR-1 also plays a role in ...
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Protease-activated receptor-2 : a novel pathogenic pathway in a murine model of osteoarthritis
... target. Protease-activated receptor-2 (PAR-2) is a G-protein coupled receptor whose ‘tethered’ ligand is activated by serine ...
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Activation of protease-activated receptor 2 reduces glioblastoma cell apoptosis
... Protease-activated receptor (PAR) 2 is a member of the large family of 7-transmembrane receptors that cou- ple to guanosine-nucleotide-binding ...be activated by proteolytic cleavage of its ...
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Mucosal sensitization to German cockroach involves protease-activated receptor-2
... Interestingly protease-depleted GC frass bound to alum and administered by intraperitoneal injection decreased total serum IgE ...to protease activity or may be a non-specific ...
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Protease Activated Receptor 4 as a Novel Modulator of Regulatory T Cell Function
... also activated with anti-CD3/anti-CD28 for varied time points, and the levels of pAkt and pFoxo1 analyzed in western blots (C) and quantified against beta-actin [(D,E), ...also activated with IL-2 for 30 ...
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Novel role for proteinase-activated receptor 2 (PAR2) in membrane trafficking of proteinase-activated receptor 4 (PAR4)
... and 250 m M sucrose, pH 7.4) supplemented with protease inhibitors (25 g/ml of leupeptin, 10 g/ml of aprotinin, and 1 g/ml of PMSF). The cell lysate was homogenized using a pre- cooled cell homogenizer ...
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Mast cell tryptase regulates rat colonic myocytes through proteinase activated receptor 2
... PAR-1 is expressed by platelets, endothelial cells, fibro- blasts, and astrocytes where it mediates many of the biological actions of thrombin (4). PAR-2 is expressed in the gastrointes- tinal tract, pancreas, kidney, ...
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Design, Synthesis, and Evaluation of Novel Protease-Activated Receptor 2 (PAR2)-Targeting Imaging Agents for Cancer
... Protease-activated receptors (PARs) are a subfamily of G protein-coupled receptors (GPCRs). GPCRs are cell membrane receptors that are involved in a broad range of cellular processes, making them common ...
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Anti-Inflammatory mechanisms of the proteinase-activated receptor 2-inhibiting peptide in human synovial cells
... serine protease-mediated cleavage of the N-terminus of the receptors ...the receptor to initiate signaling ...When activated, PAR- 2 is coupled to nuclear factor (NF)-B activation in cells ...
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Clathrin-dependent internalization of protease-activated receptor-1: regulation by ubiquitination and epsin
... activate the non-receptor tyrosine kinase Src leading to actin rearrangement and recruitment, followed by dynamin recruitment and activation that helps to detach the caveolae from the plasma membrane [123]. ...
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Thrombin promotes fibronectin secretion by bone marrow mesenchymal stem cells via the protease-activated receptor mediated signalling pathways
... Cells were washed twice with cold PBS, and then lysed with fresh RIPA containing a cocktail of protease inhibi- tors, including 1 mM PMSF, 5 mM EDTA and 1 mM phosphatase inhibitor. Cells were scraped off the ...
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The proteinase activated receptor 2 (PAR 2) mediates mitogenic responses in human vascular endothelial cells
... between protease activation and ...thrombin receptor–activating peptides to recapitulate all of thrombin’s known cellular effects remains controversial (9, 30 ...
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Conserved Structure and Adjacent Location of the Thrombin Receptor and Protease-Activated Receptor 2 Genes Define a Protease-Activated Receptor Gene Cluster
... Analysis of A phage and cosmid genomic clones revealed a two-exon structure for the mouse and human thrombin receptor genes.. The first exon.[r] ...
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Protease and Protease Activated Receptor 2 Signaling in the Pathogenesis of Atopic Dermatitis
... activating protease-activated receptors (PARs), the G-protein-coupled ...and protease inhibitors associated with genetic defects in the protease/protease inhibitor encoding genes, ...
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Protease-activated receptor 4 variant p.Tyr157Cys reduces platelet functional responses and alters receptor trafficking
... The common coding PAR4 A120T variant (rs773902), has previously been associated with gain of PAR4 receptor function. 19 Since the index case Y157C.1 was heterozygous for A120T, this may have modified the phenotype ...
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Mandatory role of proteinase-activated receptor 1 in experimental bladder inflammation
... An additional goal of this paper was to determine whether PA receptors are part of the inflammatory cascade mediat- ing the response of the urinary bladder to known pro- inflammatory stimuli. The stimuli were chosen ...
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Adding a New Anticoagulant or Antiplatelet Agent for Patient Receiving Aspirin after an Acute Coronary Syndrome?--Results from a Pairwise and Network Meta-Analysis of Randomized-Controlled Trials
... We conducted an electronic literature search for all prospective randomized controlled trials evaluating the efficacy and safety of a newly invented anticoagulant or antiplatelet agent for patients receiving aspirin ...
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Proteinase-activated receptor 4 stimulation-induced epithelial-mesenchymal transition in alveolar epithelial cells
... A549 cells were stimulated with test drugs in DMEM in the presence (for E-cadherin and α -SMA detection) or absence (for pEGFR and pSrc detection) of 1 % FCS for the indicated periods followed by harvest. The cells were ...
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Proteinase-activated receptor-2: two potential inflammatory mediators of the gastrointestinal tract in Atlantic salmon
... Proteinase-activated receptor 2 (PAR-2), activated by trypsin and other serine proteinases, is a key initiator of inflammatory responses in the intestine of ...
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