Proteasome activity
Proteasome Activity Is Influenced by the HECT_2 Protein Ipa1 in Budding Yeast
... the proteasome core ...the proteasome (Heinemeyer et ...cells, proteasome activity is decreased or that a general increase of substrate degradation takes place that leads to decreased turnover ...
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Proteasome activity related with the daily physical activity of COPD patients
... higher proteasome activity and protein carbonyl than ...Circulating proteasome activity was significantly negatively correlated with DPA (r =- ...with proteasome activity (r = ...
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Protein synthesis is lowered while 20S proteasome activity is maintained following acclimation to low temperature in juvenile spotted wolffish (Anarhichas minor Olafsen)
... enzyme activity was linear in the studied range of temperature and there is no reason to believe that the fish express different isoforms of proteasome at different ...the proteasome should be the ...
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Proteasome activity regulates CD8+ T lymphocyte metabolism and fate specification
... while proteasome activator–treated cells exhibited decreases in these processes (Figure 8, A and ...versely, proteasome inhibitor–treated cells exhibited a decreased maximal respiratory capacity, while ...
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Cellular Proteasome Activity Facilitates Herpes Simplex Virus Entry at a Postpenetration Step
... There have been several studies on the role of the protea- some in HSV infection of cultured cells (4, 6, 11, 19–21, 28, 44). These studies were carried out under postentry conditions and at times in which newly ...
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Restriction of Human Immunodeficiency Virus Type 1 by TRIM-CypA Occurs with Rapid Kinetics and Independently of Cytoplasmic Bodies, Ubiquitin, and Proteasome Activity
... 22), proteasome inhibition caused modest enhancement of HIV-1 infection under nonrestricting conditions ...that proteasome activity was inhibited by clastolactacystin-  -lactone treatment of OMK ...
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Proteasome Subunits Relocalize during Human Cytomegalovirus Infection, and Proteasome Activity Is Necessary for Efficient Viral Gene Transcription
... the proteasome subunits tested by IFA, except for Rpn2, showed enhanced localization around the replication center as the infection progressed into early-late times, when the majority of viral transcription ...the ...
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Inhibition of Hepatitis B Virus Replication by Interferon Requires Proteasome Activity†
... of proteasome subunits was cor- related with the IFN-induced inhibition of HBV replication, we hypothesized that the proteasome might play a role in me- diating the antiviral ...for proteasome ...
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Visualizing Proteasome Activity and Intracellular Localization Using Fluorescent Proteins and Activity-Based Probes
... In addition to ABPs, quenched fluorogenic peptides can also be studied by using this method. The small peptide-based substrates of 3–4 amino acids in length that are attached to a fluorescent group such as ...
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Inhibition of Proteasome Activity Induces Aggregation of IFIT2 in the Centrosome and Enhances IFIT2-Induced Cell Apoptosis
... the proteasome system participated in the degradation, transportation, and centrosomal localization of IFIT2 protein in cells, and facilitated the IFIT2-mediated cell ...the proteasome activity ...
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Subunit-selective proteasome activity profiling uncovers uncoupled proteasome subunit activities during bacterial infections
... containing two biological replicates. Part of the right half of this figure is shown in Figure 6bd. D) Fluorescent intensity of the signals, normalized to the Mock control.. Suppressed[r] ...
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RNA interference of proteasome subunit of PSMβ7 gene restricts proteasome subunit PSMβ1 and PSMβ5 mRNA expression and peptidyl-glutamyl peptide-hydrolyzing proteasome activity in neonatal cardiomyocytes
... nonproteolytic proteasome β7 subunit, we observed a significant decrease in β1 proteolytic subunit mRNA ...expression. Proteasome peptidyl- glutamyl peptide-hydrolyzing activity decreased to 28% ...
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Downregulation of 26S proteasome catalytic activity promotes epithelial-mesenchymal transition
... β5 proteasome subunit activity is downregulated during EMT in immortalized human mammary epithelial ...selective proteasome inhibition enabled mammary epithelial cells to acquire certain morphologic ...
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Pathways of Skeletal Muscle Atrophy: HIV as a Model System?
... Skeletal Muscle Atrophy (SMA) is a phenomenon found in many diseases and disorders. SMA is characterized by protein degradation induced by various pathways. Ten years ago, little was known about the mechanisms that lead ...
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Human Cytomegalovirus Infection Dysregulates the Localization and Stability of NICD1 and Jag1 in Neural Progenitor Cells
... HCMV infection alters intracellular localization of NICD1, and inhibition of proteasome activity enhances the alteration. Immunofluorescent staining was used to further examine the im- FIG 3 HCMV infection ...
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The effect of temperature adaptation on the ubiquitin–proteasome pathway in notothenioid fishes
... mitochondrial activity while maintaining enhanced oxygen distribution (Johnston et ...– proteasome system has an important role in ensuring oxidatively damaged proteins are quickly ...– proteasome ...
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The role of the ubiquitination proteasome pathway in breast cancer: Applying drugs that affect the ubiquitin proteasome pathway to the therapy of breast cancer
... ubiquitin- proteasome activity, most notably the proteasome inhibitor PS-341, are currently being evaluated in clinical trials, and have already been found to have significant antitumor ...
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Characterization of a REG/PA28 Proteasome Activator Homolog in Dictyostelium discoideum Indicates that the Ubiquitin- and ATP-Independent REGγ Proteasome Is an Ancient Nuclear Protease
... The activity characterization of Dictyostelium REG suggests that the Dictyostelium REG protein is similar in nuclear local- ization to the ␥ class of REG proteasome activators in meta- zoans with some ...
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Trypanosoma brucei: β2-selective proteasome inhibitors do not block the proteasomal trypsin-like activity but are trypanocidal
... The proteasome is a multi-subunit protease complex that plays a crucial role in the regulation of protein degradation in ...the proteasome of the protozoan parasite Trypanosoma brucei has a cylindrical ...
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The resistance mechanisms of proteasome inhibitor bortezomib
... the proteasome work- load in myeloma cells by increasing immunoglobulin secretion, while reducing proteasome capacity by de- creasing proteasome activity, can overcome myeloma resistance to ...
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