Proteasome inhibition
Proteasome inhibition and its therapeutic potential in multiple myeloma
... why NOXA is preferentially induced in tumor cells, the myriad transcription factors with consensus binding sites at the NOXA promoter were restricted to those that are conserved (as NOXA itself is) across mammalian ...
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The docking protein p130Cas regulates cell sensitivity to proteasome inhibition
... cells, inhibition of autophagy had limited effects on Cas-FL cell apoptosis, as evidenced by PARP cleavage (Figure 6B, ...of proteasome inhibition ...
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Proteasome inhibition reduces superantigen mediated T cell activation and the severity of psoriasis in a SCID hu model
... selective proteasome inhibitor based upon the naturally occurring compound lactacystin, which inhibits NF- κ B activation by block- ing the degradation of its inhibitory protein I κ ...that proteasome ...
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The cytotoxicity of γ secretase inhibitor I to breast cancer cells is mediated by proteasome inhibition, not by γ secretase inhibition
... Z-LLNle-CHO-induced inhibition. How- ever, because inhibition of γ-secretase alone or in combination with proteasome inhibition had no effect on cell survival/prolif- eration or cellular ...
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Proteasome inhibition mediates p53 reactivation and anti- cancer activity of 6-Gingerol in cervical cancer cells
... for inhibition of proteasome function and induction of p53 reactivation is a promising strategy for induction of apoptosis in cervical cancer ...weight, proteasome inhibition and p53 ...
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Transcriptional regulation of matrix metalloproteinase 1 and collagen 1A2 explains the anti fibrotic effect exerted by proteasome inhibition in human dermal fibroblasts
... The proteasome is a barrel-shaped, multi-catalytic pro- tease complex present in the cytosol and in the nuclei and triggers degradation of multi-ubiquitinated proteins ...that proteasome inhibition ...
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Proteasome inhibition alleviates prolonged moderate compression induced muscle pathology
... of proteasome inhibitors on blocking the cell cycle entry of T cells and reducing the severity of some immune-mediated disorders have been demonstrated ...of proteasome inhibitor in deep pressure ulcer is ...
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Destabilizing NEK2 overcomes resistance to proteasome inhibition in multiple myeloma
... We found that NEK2 activates the canonical NF-κB pathway based on the following observations: (a) NEK2 expression is posi- tively correlated with increased NF-κB score in primary myeloma samples; (b) more than 40% of ...
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Proteasome inhibition and mechanism of resistance to a synthetic, library-based hexapeptide
... the Proteasome-Glo ™ cell-based assay (Promega, Leiden, The Netherlands), using Suc-LLVY-aminoluciferin as a sub- strate, according to the manufacturer’s ...
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Use of the non-radioactive SUnSET method to detect decreased protein synthesis in proteasome inhibited Arabidopsis roots
... For the first time in plants, SUnSET was used to monitor changes in protein synthesis. As anticipated, decreased protein synthesis was observed in the roots and shoots of Arabidopsis plants treated with cycloheximide. ...
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Inhibition of proteasome activity by the dietary flavonoid Quercetin associated with growth inhibition in cultured breast cancer cells and xenografts
... cellular proteasome in MCF-7 cell ...its proteasome-inhibitory activity, MCF-7 cell lines were treated with 25 μm, 50 μm, 75 μm, or 100 μm quercetin for 24 ...the proteasome Inhibition by the ...
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Inhibition of Proteasome Activity Induces Aggregation of IFIT2 in the Centrosome and Enhances IFIT2-Induced Cell Apoptosis
... the proteasome system participated in the degradation, transportation, and centrosomal localization of IFIT2 protein in cells, and facilitated the IFIT2-mediated cell ...the inhibition of the ...
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The novel beta 2-selective proteasome inhibitor LU-102 synergizes with bortezomib and carfilzomib to overcome proteasome inhibitor resistance of myeloma cells
... a proteasome inhibitor-adapted myeloma cell line model that mirrors several of the biolog- ical features of bortezomib resistance in patients, but also in a model of bone marrow stroma-mediated proteasome ...
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Inhibition of proteasome activity by the dietary flavonoid apigenin is associated with growth inhibition in cultured breast cancer cells and xenografts
... significant inhibition of proteasomal chymotrypsin-like activity, accumula- tion of proteasome target proteins (that is, Bax), and induction of apoptosis in tumors (Figure ...observed proteasome ...
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Inhibition of Hepatitis B Virus Replication by Interferon Requires Proteasome Activity†
... IFN-induced inhibition of HBV ...that proteasome activity is required for this antiviral ...by proteasome inhibition suggests that the inhibition of HBV replication induced by these two ...
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Inhibition of the Ubiquitin-Proteasome System Affects Influenza A Virus Infection at a Postfusion Step
... We first monitored the entry phase of the infection cycle by making use of the luciferase reporter system and the IAV entry inhibitor bafilomycin A1. Addition of this drug prevents endo- somal acidification, thereby ...
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The protective effects of lafutidine for bortezomib induced peripheral neuropathy
... of Proteasome inhibition for Extending remissions (APEX) study, it was reported that 31 of 331 patients (9%) had to discontinue bortezomib treatment because of BIPN, and 14 of 331 (4%) patients who ...
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The Cellular Localization Pattern of Varicella-Zoster Virus ORF29p Is Influenced by Proteasome-Mediated Degradation
... mic. Inhibition of the 26S proteasome, but not heat shock treatment, also affects the cellular distribution of ORF29p similarly to ICP0 ...Although proteasome inhibition induces ORF29p nu- ...
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Proteasome inhibitors as experimental therapeutics of autoimmune diseases
... increased proteasome activity and that this feature would render them particularly sus- ceptible to proteasome inhibition and accumulation of polyubiquitinated proteins, eliciting an apoptotic ...to ...
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Synthetic Analogs of Green Tea Polyphenols as Proteasome Inhibitors
... The aforementioned experiments demonstrate that the synthetic enantiomers of these two GTPs, ( )-EGCG and ( )-GCG, at least did not loose any, and even may have gained some potency in re- gards to proteasome ...
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