Protective antigen
New protective antigen of group A streptococci
... a protective antigen in addition to type 18 M ...streptococcal protective antigen) that evoked antibodies that opsonized the M18 parent and the M-negative ...of protective epitopes ...
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Thermal Aggregation of Recombinant Protective Antigen: Aggregate Morphology and Growth Rate
... recombinant protective antigen (rPA) (active component in a second-generation anthrax vaccine [16]) has been examined visually and via turbidity measure- ments, before information on the size and the shape ...
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Mechanistic Analysis of the Effect of Deamidation on the Immunogenicity of Anthrax Protective Antigen
... recombinant protective antigen (rPA), we have previ- ously shown that deamidation can decrease the immunogenicity of rPA, the primary component of new-generation anthrax vac- ...
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Genetic and Antigenic Diversity of the Surface Protective Antigen Proteins of Erysipelothrix rhusiopathiae
... surface protective antigen (Spa) protein of Erysipelothrix rhusiopathiae has been shown to be highly immunogenic and is a potential candidate for a new vaccine against ...promising antigen for use as ...
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Expression of the protective antigen of bacillus anthracis in attenuated salmonella : a potential oral anthrax vaccine
... toxin. Protective Antigen, can protect against challenge (Ivins & W elkos, ...the protective antigens have not been identified, or a response to a number o f antigens are required to stimulate ...
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Phase 1 Study of a Recombinant Mutant Protective Antigen of Bacillus anthracis
... A phase 1 study of a recombinant mutant protective antigen (rPA) vaccine was conducted in 186 healthy adults aged 18 to 45 years. Volunteers were randomized to receive one of three formulations of rPA ...
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Binding specificity and affinity analysis of an anti protective antigen peptide reagent using capillary electrophoresis
... Since the use of Bacillus anthracis as a bio-weapon in the US in 2001, there has been a desire for an improved method for sensing small quantities of biological threats. The Protective Antigen (PA) protein ...
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In Vitro Study of the Toxicity Effects of Bacillus anthracis Protective Antigen
... mutated protective antigen (PA) in which the furin protease cleavage site was re- placed by specific sequences, which are selectively cleaved by MMPs, can induce toxicity in MMP- overexpressing cells ...
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Computational Improvement of Small-Molecule Inhibitors of Bacillus anthracis Protective Antigen Activation through Isostere-Based Substitutions.
... Figure 1. A) Molecular surface of the protective antigen. The N-terminal portion cleaved prior to activation is colored green. The docking site studied is highlighted with a rectangular box. B) Molecular ...
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Immunogenicity of Bacillus anthracis Protective Antigen Domains and Efficacy of Elicited Antibody Responses Depend on Host Genetic Background
... Bacillus anthracis is the causative agent of anthrax. Three forms of anthrax, cutaneous, gastrointestinal, and inhalational, have been described in humans. The most serious form is inhalational anthrax, because patients ...
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A fragment of anthrax lethal factor delivers proteins to the cytosol without requiring protective antigen
... B acillus anthracis is the causative agent of anthrax in animals and humans. It produces two bipartite protein exotoxins, lethal toxin (LeTx) and edema toxin. LeTx is composed of protective antigen (PA) and ...
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Analysis of Antibody Responses to Protective Antigen-Based Anthrax Vaccines through Use of Competitive Assays
... The encapsulated, toxigenic species Bacillus anthracis causes cutaneous, gastrointestinal, and inhalational anthrax disease in humans (4). In 2001, B. anthracis was deliberately released through the United States postal ...
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Anti-Protective Antigen IgG Enzyme-Linked Immunosorbent Assay for Diagnosis of Cutaneous Anthrax in India
... Anthrax caused by Bacillus anthracis is a public health problem in several developing countries whose main source of income is farming. Anthrax is a disease of herbivorous animals, and humans can be infected by handling ...
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Different mechanisms of two anti anthrax protective antigen antibodies and function comparison between them
... The pathogenesis of B. anthracis is mainly caused by anthrax toxin which is a tripartite protein complex. The three-protein toxin consist of a cellular receptors bind- ing component, the protective antigen ...
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Role of the Antigen Capture Pathway in the Induction of a Neutralizing Antibody Response to Anthrax Protective Antigen
... of protective immunity against a number of toxin-mediated bacterial diseases, including anthrax; however, the cellular mechanisms that lead to optimal neutralizing antibody re- sponses remain ill ...thrax ...
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Human monoclonal anti protective antigen antibody for the low dose post exposure prophylaxis and treatment of Anthrax
... Bacillus anthracis , a Gram-positive bacterium, causes illness and death in animals and humans [1]. Given the historical weaponization of this agent since World War II, the bacterium is considered a biological threat, ...
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Protective Antigen and Toxin Neutralization Antibody Patterns in Anthrax Vaccinees Undergoing Serial Plasmapheresis
... Laboratory studies. Antibodies to B. anthracis PA were measured using a modification of a previously described indirect enzyme-linked immunosorbent assay (ELISA) (34). In brief, twofold serial dilutions of serum from ...
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Structural and Immunological Analysis of Anthrax Recombinant Protective Antigen Adsorbed to Aluminum Hydroxide Adjuvant
... New anthrax vaccines currently under development are based on recombinant protective antigen (rPA) and formulated with aluminum adjuvant. Because long-term stability is a desired characteristic of these ...
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Activity of the Bacillus anthracis20 kDa protective antigen component
... Background: Anthrax is caused by Bacillus anthracis that produce two exotoxins, lethal toxin and edema toxin. The lethal toxin is composed of the lethal factor (LF) complexed with the cell binding protective ...
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Characterization of Dominant-Negative Forms of Anthrax Protective Antigen
... Certain mutations within the protective antigen (PA) moiety of anthrax toxin endow the protein with a dominant-negative (DN) phenotype, converting it into a potent antitoxin. Proteolytically activated PA ...
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