protein adducts
Monoclonal autoantibodies specific for oxidized phospholipids or oxidized phospholipid–protein adducts inhibit macrophage uptake of oxidized low density lipoproteins
... Schiff-base adducts with lysine residues of the intimately associated apoprotein of LDL, ...such adducts, leading to modified lipid–protein adducts or lipid–lipid adducts ...
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Transfer of 15 lipoxygenase gene into rabbit iliac arteries results in the appearance of oxidation specific lipid protein adducts characteristic of oxidized low density lipoprotein
... Oxidized low density lipoprotein (LDL) possesses several atherogenic properties. The mechanisms by which LDL becomes oxidized in vivo remain unknown, but previous studies have suggested that 15-lipoxygenase may be one of ...
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Protein adducts as measures of exposure in epidemiological research
... children. Protein adducts in DBS offer valuable opportunities for investigating such chemical exposures in utero and their possible links to adverse health ...
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Malondialdehyde and 4 hydroxynonenal protein adducts in plasma and liver of rats with iron overload
... aldehyde-protein adducts in the cytosol of periportal hepatocytes, which co-localized with ...4-HNE-lysine adducts were found in plasma proteins of animals with iron ...MDA adducts were ...
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Detection of Acetaminophen Protein Adducts in Children With Acute Liver Failure of Indeterminate Cause
... HPLC-EC assay, adducts were detected in the vast ma- jority (90%) of patients with ALF attributed to APAP ingestion. For patients in this subgroup, the diagnosis of APAP-related ALF had been made on the basis of ...
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Blood pyrrole-protein adducts as a diagnostic and prognostic index in pyrrolizidine alkaloid-hepatic sinusoidal obstruction syndrome
... not been used in patients with HSOS caused by PAs. Our data showed that blood PPA levels in PA-associated HSOS patients who died from liver injury within 6 months or who underwent liver transplantation were significantly ...
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PubMedCentral-PMC5589919.pdf
... peroxidation may react with endogenous FA, leading to MDA-FA (M2FA) protein adducts (Fig. 1b). Furthermore, most previously published reports on the subject of M2AA epitope detection have utilized ...
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Nonenzymatic addition of glucocorticoids to lens proteins in steroid induced cataracts
... A frequent manifestation of long-term glucocorticoid administration is the occurrence of posterior subcapsular cataracts. The molecular basis for this effect has not yet been elucidated. The addition of prednisolone to ...
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Mutation of cysteine 46 in IKK-beta increases inflammatory responses
... We next characterized the binding capability of DMY with the known drug-targeted regions of IKK-β, including the Cys-179 binding site for manumycin A, butein, berberine and arsenite [21, 26, 27, 34], and the homotypic ...
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Acetaminophen-cysteine adducts during therapeutic dosing and following overdose
... The metabolism of acetaminophen by CYP2E1 forms N -acetyl- p -benzoquinone imine (NAPQI), a reactive metabolite that binds to cysteine residues in cellular proteins and forms acetaminophen protein adducts, ...
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Serum Level of Antibodies (IgG, IgM) Against Benzo[a]pyrene-7,8-diol-9,10-epoxide-DNA Adducts in Children Dermatologically Exposed to Coal Tar
... BPDE-protein adducts (14). In- creased levels of BPDE adducts indicate recent genotoxic exposure to BaP ...related adducts in smokers ...
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Modeling conformational dynamics of cisplatin and oxaliplatin adducts with DNA
... Since 1978, cis-diamminedichloroplatinum(II) (cisplatin, CP) has been the most widely used platinum (Pt) agent in chemotherapy as a treatment for certain cancers, such as testicular, ovarian, bladder, gullet ...
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Synthesis and Reactivity of Alkylaluminum Adducts of Zirconium Ketene and Ketone Complexes
... Alkylaluminum complexes appear to be es- pecially well suited as cocatalysts because they transmetallate readily with transition metal halides and are sufficiently Lewis acidic[r] ...
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Characterization of Halogen Bonded Adducts in Solution by Advanced NMR Techniques
... the only adduct present in solution and (ii) the two components do not self-aggregate. [12,15] Sometimes, if the X-ray structure of the adduct is available, it can be assumed that the stoichiometry in solution is the ...
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Review: Adducts and Clusters in Chromatography, Mass Spectrometry and Nature
... The theoretical background of clusters’ behavior in different systems including the life organisms is in juvenile phase; however, it is important, fruitful and very needed for understanding the subject. We consist and ...
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Thermochemical Parameters of Tetramethylthiourea Adducts of Certain Metal(II) Bromides
... Tetramethylthiourea; n is 0.75, 2 or 3) were obtained by the reaction of salts and ligand in solu- tion. The bromides were selected among several other salts because they had thermochemical data in the literature. ...
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Synthesis and Characterisation of N-Heterocyclic Carbene Adducts of PI Cations
... accomplished at room temperature. In contrast, the use of an analogous reaction protocol to obtain cyclic bis-NHC adducts has proven to be not as straightforward. The problem with the bis-NHC proligands is their ...
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Bulky DNA adducts in human sperm associated with semen parameters and sperm DNA fragmentation in infertile men: a cross-sectional study
... The statistical analyses were performed with Statistical Analysis System software (version 9.1.3, SAS Institute, Cary, NC). All tests were two-sided and the significance level was set at P < 0.05. Linear regression ...
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Synthesis, characterization and antifungal activities of adducts of nickel(II)thioxanthates with oxygen donor ligands
... 1:2 Adducts of Nickel(II)thioxanthates with dimethylsulphoxide and hexamethylphosphoramide have been ...resulting adducts have been characterized by elemental analysis, molar conductance, magnetic ...
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DC isoketal modified proteins activate T cells and promote hypertension
... isoketal-lysine adducts on any protein (19), showed that there was an exuberant accumulation of isoketals in the hearts and vasculatures of hypertensive mice (Figure 1, E and ...
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